fMRI resting state connectivity between language and non-language areas as defined by intraoperative electrocortical stimulation in low grade glioma patients

Jasper van Lieshout, Wouter De Baene, Marion Rapp, Herke Jan Noordmans, Geert-Jan Rutten*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background and Objectives 

It remains to be determined whether noninvasive functional imaging techniques can rival the clinical potential of direct electrocortical stimulation (DES). In this study, we compared the results of resting-state functional magnetic resonance imaging (rs-fMRI) to those of DES for language mapping. Our goals were twofold: (1) to replicate a previous study that demonstrated that resting-state connectivity (RSC) was significantly larger between positive DES language sites than between negative DES language sites and (2) to compare the spatial resolution of rs-fMRI to that of DES.

Methods 

We conducted a retrospective study of nine low-grade glioma patients. Language sites were identified by intraoperative DES. We compared RSC values between and within groups of DES-positive and DES-negative regions of interest (ROIs). Both close-negative sites (i.e., DES-negative sites

Results 

Functional connectivity between all positive language sites was on average significantly higher than between all close-negative sites and between all far-negative sites. The functional connectivity between the positive language ROIs and their respective close-negative control sites was not smaller than between all positive language sites.

Conclusion 

rs-fMRI likely reflects similar neural information as detected with DES, but in its current form does not reach the spatial resolution of DES.

Original languageEnglish
Pages (from-to)357-363
JournalJournal of Neurological Surgery Part A
Volume82
Issue number4
DOIs
Publication statusPublished - Jul 2021

Keywords

  • direct electrocortical stimulation
  • glioma
  • language
  • resting-state fMRI

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