fMRI resting state connectivity between language and non-language areas as defined by intraoperative electrocortical stimulation in low grade glioma patients

Jasper van Lieshout, Wouter De Baene, Marion Rapp, Herke Jan Noordmans, Geert-Jan Rutten*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Objectives:
It remains to be determined whether non-invasive functional imaging techniques can rival the clinical potential of direct electrocortical stimulation (DES). In this study, we compared the results of resting state fMRI to those of DES for language mapping. Our goals were two- fold: (1) to replicate a previous study that demonstrated that resting state connectivity (RSC) was significantly larger between positive than between negative DES language sites; (2) to compare the spatial resolution of rs-fMRI to that of DES.

Methods:
We conducted a retrospective study of nine low-grade glioma patients. Language sites were identified by intraoperative DES. We compared RSC values between and within groups of DES-positive and DES-negative regions of interest (ROI). Both close-negative sites (i.e. DES-negative sites less than 1 cm apart from and on the same gyrus as DES-positive sites) as far-negative sites (i.e. purely randomly chosen sites not in the vicinity of the tumor or of the DES-positive sites but on the same lobe) were included. Receiver operating characteristics were used to quantify comparisons.

Results:
Functional connectivity between all positive language sites was on average significantly higher than between all close-negative sites, and than between all far-negative sites. The functional connectivity between the positive language ROIs and their respective close-negative control sites was not smaller than between all positive language sites.

Conclusion:
rs-fMRI likely reflects similar neural information as detected with direct electrocortical stimulation, but in its current form does not reach the spatial resolution of DES.
Original languageEnglish
JournalJournal of Neurological Surgery Part A
Publication statusAccepted/In press - 2020

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