Functional connectome of the fetal brain

Elise Turk, Marion I. Van Den Heuvel, Manon J. Benders, Roel De Heus, Arie Franx, Janessa H. Manning, Jasmine L. Hect, Edgar Hernandez-Andrade, Sonia S. Hassan, Roberto Romero, René S. Kahn, Moriah E. Thomason, Martijn P. Van Den Heuvel

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Large-scale functional connectome formation and reorganization is apparent in the second trimester of pregnancy, making it a crucial and vulnerable time window in connectome development. Here we identified which architectural principles of functional connectome organization are initiated before birth, and contrast those with topological characteristics observed in the mature adult brain. A sample of 105 pregnant women participated in human fetal resting-state fMRI studies (fetal gestational age between 20 and 40 weeks). Connectome analysis was used to analyze weighted network characteristics of fetal macroscale brain wiring. We identified efficient network attributes, common functional modules, and high overlap between the fetal and adult brain network. Our results indicate that key features of the functional connectome are present in the second and third trimesters of pregnancy. Understanding the organizational principles of fetal connectome organization may bring opportunities to develop markers for early detection of alterations of brain function.
Original languageEnglish
Pages (from-to)9716-9724
JournalJournal of Neuroscience
Volume39
Issue number49
DOIs
Publication statusPublished - 2019

Keywords

  • ARCHITECTURE
  • CHILDREN
  • CONNECTIVITY NETWORKS
  • EMERGENCE
  • EXPOSURE
  • NEWBORN BRAIN
  • PRETERM INFANTS
  • RESTING-STATE FMRI
  • RICH-CLUB ORGANIZATION
  • WORKING-MEMORY
  • brain development
  • fetal
  • functional connectivity
  • prenatal
  • resting-state fMRI

Fingerprint Dive into the research topics of 'Functional connectome of the fetal brain'. Together they form a unique fingerprint.

  • Cite this

    Turk, E., Van Den Heuvel, M. I., Benders, M. J., De Heus, R., Franx, A., Manning, J. H., Hect, J. L., Hernandez-Andrade, E., Hassan, S. S., Romero, R., Kahn, R. S., Thomason, M. E., & Van Den Heuvel, M. P. (2019). Functional connectome of the fetal brain. Journal of Neuroscience, 39(49), 9716-9724. https://doi.org/10.1523/JNEUROSCI.2891-18.2019