TY - JOUR
T1 - Functional hierarchy of oculomotor and visual motion subnetworks within the human cortical optokinetic system
AU - Ruehl, Ria Maxine
AU - Hoffstaedter, Felix
AU - Reid, Andrew
AU - Eickhoff, Simon
AU - zu Eulenburg, Peter
N1 - Funding Information:
Funding This work was supported by the German Federal Ministry of Education and Research (BMBF 01 EO 0901).
Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/3/4
Y1 - 2019/3/4
N2 - Optokinetic look nystagmus (look OKN) is known to engage cortical visual motion and oculomotor hubs. Their functional network hierarchy, however, and the role of the cingulate eye field (CEF) and the dorsolateral prefrontal cortex (DLPFC) in particular have not been investigated. We used look OKN in fMRI to identify all cortical visual motion and oculomotor hubs involved. Using these activations as seed regions, we employed hierarchical clustering in two differing resting state conditions from a separate public data set. Robust activations in the CEF highlight its functional role in OKN and involvement in higher order oculomotor control. Deactivation patterns indicate a decreased modulatory involvement of the DLPFC. The hierarchical clustering revealed a changeable organization of the eye fields, hMT, V3A, and V6 depending on the resting state condition, segregating executive from higher order visual subnetworks. Overall, hierarchical clustering seems to allow for a robust delineation of physiological cortical networks.
AB - Optokinetic look nystagmus (look OKN) is known to engage cortical visual motion and oculomotor hubs. Their functional network hierarchy, however, and the role of the cingulate eye field (CEF) and the dorsolateral prefrontal cortex (DLPFC) in particular have not been investigated. We used look OKN in fMRI to identify all cortical visual motion and oculomotor hubs involved. Using these activations as seed regions, we employed hierarchical clustering in two differing resting state conditions from a separate public data set. Robust activations in the CEF highlight its functional role in OKN and involvement in higher order oculomotor control. Deactivation patterns indicate a decreased modulatory involvement of the DLPFC. The hierarchical clustering revealed a changeable organization of the eye fields, hMT, V3A, and V6 depending on the resting state condition, segregating executive from higher order visual subnetworks. Overall, hierarchical clustering seems to allow for a robust delineation of physiological cortical networks.
KW - Cingulate eye field
KW - Functional connectivity
KW - Hierarchical clustering
KW - Ocular motor control
KW - Optokinetic nystagmus
UR - http://www.scopus.com/inward/record.url?scp=85056297322&partnerID=8YFLogxK
U2 - 10.1007/s00429-018-1788-9
DO - 10.1007/s00429-018-1788-9
M3 - Article
C2 - 30421037
AN - SCOPUS:85056297322
SN - 1863-2653
VL - 224
SP - 567
EP - 582
JO - Brain Structure and Function
JF - Brain Structure and Function
IS - 2
ER -