General psychopathology factor and unresolved-disorganized attachment uniquely correlated to white matter integrity using diffusion tensor imaging.

M.M.E. Riem, Marie-Jose van Hoof, Amy Garrett, S.A.R.B. Rombouts, N.J.A. Van der Wee, M.H. van IJzendoorn, R.R.J.M. Vermeiren

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background
A dimensional approach of psychopathology focuses on features and risk factors that are shared across diagnoses. In support for this dimensional approach, studies point to a general psychopathology factor (GPF) associated with risk for multiple psychiatric disorders. It is, however, unknown how GPF relates to white matter integrity (WMI). In the current diffusion tensor imaging (DTI) study, we examined how GPF relates to abnormalities in a skeleton representation of white matter tracts, taking into account a trans-diagnostic risk factor: unresolved-disorganized attachment (Ud) resulting from loss or trauma.
Methods
Unique associations between GPF, Ud, and WMI were examined in a combined sample of adolescents (N = 63) with childhood sexual abuse-related posttraumatic stress disorder (N = 18), anxiety and depressive disorders (N = 26) and without psychiatric disorder (N = 19). WMI was measured using DTI. Ud was measured using the Adult Attachment Interview. We controlled for puberty stage, gender, age, and IQ.
Results
Controlling for GPF, Ud was associated with reduced fractional anisotropy (FA) in the splenium and inferior fronto-occipital fasciculus (IFOF). Controlling for Ud, GPF was associated with reduced FA in the genu and body of the corpus callosum.
Conclusions
Decreasing WMI in the genu and body with increasing psychopathology across diagnoses suggests demyelinization in these areas and may underlie comorbidity and presence of symptoms that transcend psychopathological diagnoses. In contrast, trauma-related WMI reductions in the splenium and IFOF may account for heterogeneity within diagnostic categories as a function of childhood trauma. These findings support the importance of a dimensional approach in addition to traditional diagnostic classifications in clinical research and practice.
Original languageEnglish
Pages (from-to)1-8
JournalBehavioural Brain Research
Volume359
DOIs
Publication statusPublished - 2019

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Diffusion Tensor Imaging
Anisotropy
Wounds and Injuries
Corpus Callosum
Comorbidity
Interviews

Keywords

  • ADOLESCENTS
  • Adversity
  • Attachment
  • BRAIN
  • Brain imaging
  • CHILDHOOD SEXUAL-ABUSE
  • CHILDREN
  • CORPUS-CALLOSUM
  • Child abuse
  • DEPRESSION
  • DISORDER
  • HERITABILITY
  • MALTREATMENT
  • Psychopathology
  • RESILIENCE

Cite this

Riem, M.M.E. ; van Hoof, Marie-Jose ; Garrett, Amy ; Rombouts, S.A.R.B. ; Van der Wee, N.J.A. ; van IJzendoorn, M.H. ; Vermeiren, R.R.J.M. / General psychopathology factor and unresolved-disorganized attachment uniquely correlated to white matter integrity using diffusion tensor imaging. In: Behavioural Brain Research. 2019 ; Vol. 359. pp. 1-8.
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title = "General psychopathology factor and unresolved-disorganized attachment uniquely correlated to white matter integrity using diffusion tensor imaging.",
abstract = "BackgroundA dimensional approach of psychopathology focuses on features and risk factors that are shared across diagnoses. In support for this dimensional approach, studies point to a general psychopathology factor (GPF) associated with risk for multiple psychiatric disorders. It is, however, unknown how GPF relates to white matter integrity (WMI). In the current diffusion tensor imaging (DTI) study, we examined how GPF relates to abnormalities in a skeleton representation of white matter tracts, taking into account a trans-diagnostic risk factor: unresolved-disorganized attachment (Ud) resulting from loss or trauma.MethodsUnique associations between GPF, Ud, and WMI were examined in a combined sample of adolescents (N = 63) with childhood sexual abuse-related posttraumatic stress disorder (N = 18), anxiety and depressive disorders (N = 26) and without psychiatric disorder (N = 19). WMI was measured using DTI. Ud was measured using the Adult Attachment Interview. We controlled for puberty stage, gender, age, and IQ.ResultsControlling for GPF, Ud was associated with reduced fractional anisotropy (FA) in the splenium and inferior fronto-occipital fasciculus (IFOF). Controlling for Ud, GPF was associated with reduced FA in the genu and body of the corpus callosum.ConclusionsDecreasing WMI in the genu and body with increasing psychopathology across diagnoses suggests demyelinization in these areas and may underlie comorbidity and presence of symptoms that transcend psychopathological diagnoses. In contrast, trauma-related WMI reductions in the splenium and IFOF may account for heterogeneity within diagnostic categories as a function of childhood trauma. These findings support the importance of a dimensional approach in addition to traditional diagnostic classifications in clinical research and practice.",
keywords = "ADOLESCENTS, Adversity, Attachment, BRAIN, Brain imaging, CHILDHOOD SEXUAL-ABUSE, CHILDREN, CORPUS-CALLOSUM, Child abuse, DEPRESSION, DISORDER, HERITABILITY, MALTREATMENT, Psychopathology, RESILIENCE",
author = "M.M.E. Riem and {van Hoof}, Marie-Jose and Amy Garrett and S.A.R.B. Rombouts and {Van der Wee}, N.J.A. and {van IJzendoorn}, M.H. and R.R.J.M. Vermeiren",
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doi = "10.1016/j.bbr.2018.10.014",
language = "English",
volume = "359",
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journal = "Behavioural Brain Research",
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General psychopathology factor and unresolved-disorganized attachment uniquely correlated to white matter integrity using diffusion tensor imaging. / Riem, M.M.E.; van Hoof, Marie-Jose; Garrett, Amy; Rombouts, S.A.R.B.; Van der Wee, N.J.A.; van IJzendoorn, M.H.; Vermeiren, R.R.J.M.

In: Behavioural Brain Research, Vol. 359, 2019, p. 1-8.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - General psychopathology factor and unresolved-disorganized attachment uniquely correlated to white matter integrity using diffusion tensor imaging.

AU - Riem, M.M.E.

AU - van Hoof, Marie-Jose

AU - Garrett, Amy

AU - Rombouts, S.A.R.B.

AU - Van der Wee, N.J.A.

AU - van IJzendoorn, M.H.

AU - Vermeiren, R.R.J.M.

PY - 2019

Y1 - 2019

N2 - BackgroundA dimensional approach of psychopathology focuses on features and risk factors that are shared across diagnoses. In support for this dimensional approach, studies point to a general psychopathology factor (GPF) associated with risk for multiple psychiatric disorders. It is, however, unknown how GPF relates to white matter integrity (WMI). In the current diffusion tensor imaging (DTI) study, we examined how GPF relates to abnormalities in a skeleton representation of white matter tracts, taking into account a trans-diagnostic risk factor: unresolved-disorganized attachment (Ud) resulting from loss or trauma.MethodsUnique associations between GPF, Ud, and WMI were examined in a combined sample of adolescents (N = 63) with childhood sexual abuse-related posttraumatic stress disorder (N = 18), anxiety and depressive disorders (N = 26) and without psychiatric disorder (N = 19). WMI was measured using DTI. Ud was measured using the Adult Attachment Interview. We controlled for puberty stage, gender, age, and IQ.ResultsControlling for GPF, Ud was associated with reduced fractional anisotropy (FA) in the splenium and inferior fronto-occipital fasciculus (IFOF). Controlling for Ud, GPF was associated with reduced FA in the genu and body of the corpus callosum.ConclusionsDecreasing WMI in the genu and body with increasing psychopathology across diagnoses suggests demyelinization in these areas and may underlie comorbidity and presence of symptoms that transcend psychopathological diagnoses. In contrast, trauma-related WMI reductions in the splenium and IFOF may account for heterogeneity within diagnostic categories as a function of childhood trauma. These findings support the importance of a dimensional approach in addition to traditional diagnostic classifications in clinical research and practice.

AB - BackgroundA dimensional approach of psychopathology focuses on features and risk factors that are shared across diagnoses. In support for this dimensional approach, studies point to a general psychopathology factor (GPF) associated with risk for multiple psychiatric disorders. It is, however, unknown how GPF relates to white matter integrity (WMI). In the current diffusion tensor imaging (DTI) study, we examined how GPF relates to abnormalities in a skeleton representation of white matter tracts, taking into account a trans-diagnostic risk factor: unresolved-disorganized attachment (Ud) resulting from loss or trauma.MethodsUnique associations between GPF, Ud, and WMI were examined in a combined sample of adolescents (N = 63) with childhood sexual abuse-related posttraumatic stress disorder (N = 18), anxiety and depressive disorders (N = 26) and without psychiatric disorder (N = 19). WMI was measured using DTI. Ud was measured using the Adult Attachment Interview. We controlled for puberty stage, gender, age, and IQ.ResultsControlling for GPF, Ud was associated with reduced fractional anisotropy (FA) in the splenium and inferior fronto-occipital fasciculus (IFOF). Controlling for Ud, GPF was associated with reduced FA in the genu and body of the corpus callosum.ConclusionsDecreasing WMI in the genu and body with increasing psychopathology across diagnoses suggests demyelinization in these areas and may underlie comorbidity and presence of symptoms that transcend psychopathological diagnoses. In contrast, trauma-related WMI reductions in the splenium and IFOF may account for heterogeneity within diagnostic categories as a function of childhood trauma. These findings support the importance of a dimensional approach in addition to traditional diagnostic classifications in clinical research and practice.

KW - ADOLESCENTS

KW - Adversity

KW - Attachment

KW - BRAIN

KW - Brain imaging

KW - CHILDHOOD SEXUAL-ABUSE

KW - CHILDREN

KW - CORPUS-CALLOSUM

KW - Child abuse

KW - DEPRESSION

KW - DISORDER

KW - HERITABILITY

KW - MALTREATMENT

KW - Psychopathology

KW - RESILIENCE

U2 - 10.1016/j.bbr.2018.10.014

DO - 10.1016/j.bbr.2018.10.014

M3 - Article

VL - 359

SP - 1

EP - 8

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -