Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Research output: Contribution to journalArticleScientificpeer-review

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
Original languageUndefined/Unknown
JournalNature Genetics
DOIs
Publication statusPublished - 17 Sep 2018
Externally publishedYes

Cite this

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title = "Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.",
abstract = "High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.",
author = "Ruifang Li",
year = "2018",
month = "9",
day = "17",
doi = "10.1038/s41588-018-0205-x",
language = "Undefined/Unknown",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. / Li, Ruifang.

In: Nature Genetics, 17.09.2018.

Research output: Contribution to journalArticleScientificpeer-review

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AB - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

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