Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Ruifang Li

doi:10.1038/s41588-018-0205-x

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Ruifang Li

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Original language	Undefined/Unknown
Journal	Nature Genetics
DOIs	https://doi.org/10.1038/s41588-018-0205-x
Publication status	Published - 17 Sept 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1038/s41588-018-0205-x

Cite this

@article{73c94674877c47558509f8b511e08373,

title = "Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.",

abstract = "High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.",

author = "Ruifang Li",

year = "2018",

month = sep,

day = "17",

doi = "10.1038/s41588-018-0205-x",

language = "Undefined/Unknown",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

}

TY - JOUR

T1 - Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

AU - Li, Ruifang

PY - 2018/9/17

Y1 - 2018/9/17

N2 - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

AB - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

UR - http://europepmc.org/articles/PMC6284793

U2 - 10.1038/s41588-018-0205-x

DO - 10.1038/s41588-018-0205-x

M3 - Article

C2 - 30224653

SN - 1061-4036

JO - Nature Genetics

JF - Nature Genetics

ER -

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Abstract

UN SDGs

Access to Document

Other files and links

Cite this