Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case-control study

Ruifang Li-Gao*, Vânia M. Morelli, Willem M. Lijfering, Suzanne C. Cannegieter, Frits R. Rosendaal, Astrid van Hylckama Vlieg

*Corresponding author for this work

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It is unclear whether hyperglycaemia or diabetes mellitus are risk factors for a first venous thrombosis (VT). Self-reported diabetes status and fasting glucose (FG) measures were collected from the Multiple Environmental and Genetic Assessment (MEGA) study to confirm these associations. FG levels were categorized based on the World Health Organization criteria [= 7 center dot 0 (3rd) mmol/l]. Logistic regression was performed to quantify the associations. Neither increased FG levels [Odds ratio (95% confidence interval): 0 center dot 98 (0 center dot 69-1 center dot 37) 2nd vs. reference, 0 center dot 97 (0 center dot 58-1 center dot 63) 3rd vs. reference] nor self-reported diabetes [1 center dot 12 (0 center dot 80-1 center dot 58)] were associated with an increased risk of a first VT.

Original languageEnglish
Pages (from-to)431-435
JournalBritish Journal of Haematology
Issue number3
Publication statusPublished - 2019



  • case-control studies
  • hyperglycaemia
  • odds ratio
  • type 2 diabetes mellitus
  • venous thrombosis

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