Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case-control study

Ruifang Li-Gao; Vânia M. Morelli; Willem M. Lijfering; Suzanne C. Cannegieter; Frits R. Rosendaal; Astrid van Hylckama Vlieg

doi:10.1111/bjh.15599

Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case-control study

Ruifang Li-Gao^*, Vânia M. Morelli, Willem M. Lijfering, Suzanne C. Cannegieter, Frits R. Rosendaal, Astrid van Hylckama Vlieg

^*Corresponding author for this work

Medical and Clinical Psychology

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Abstract

It is unclear whether hyperglycaemia or diabetes mellitus are risk factors for a first venous thrombosis (VT). Self-reported diabetes status and fasting glucose (FG) measures were collected from the Multiple Environmental and Genetic Assessment (MEGA) study to confirm these associations. FG levels were categorized based on the World Health Organization criteria [= 7 center dot 0 (3rd) mmol/l]. Logistic regression was performed to quantify the associations. Neither increased FG levels [Odds ratio (95% confidence interval): 0 center dot 98 (0 center dot 69-1 center dot 37) 2nd vs. reference, 0 center dot 97 (0 center dot 58-1 center dot 63) 3rd vs. reference] nor self-reported diabetes [1 center dot 12 (0 center dot 80-1 center dot 58)] were associated with an increased risk of a first VT.

Original language	English
Pages (from-to)	431-435
Journal	British Journal of Haematology
Volume	184
Issue number	3
DOIs	https://doi.org/10.1111/bjh.15599
Publication status	Published - 2019

Keywords

HYPERGLYCEMIA
MELLITUS
METAANALYSIS
THROMBOEMBOLISM
case-control studies
hyperglycaemia
odds ratio
type 2 diabetes mellitus
venous thrombosis

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MCP Ruifang Li glucose levels and diabetes BjoH 2019Final published version, 95.1 KB

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title = "Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case-control study",

abstract = "It is unclear whether hyperglycaemia or diabetes mellitus are risk factors for a first venous thrombosis (VT). Self-reported diabetes status and fasting glucose (FG) measures were collected from the Multiple Environmental and Genetic Assessment (MEGA) study to confirm these associations. FG levels were categorized based on the World Health Organization criteria [= 7 center dot 0 (3rd) mmol/l]. Logistic regression was performed to quantify the associations. Neither increased FG levels [Odds ratio (95% confidence interval): 0 center dot 98 (0 center dot 69-1 center dot 37) 2nd vs. reference, 0 center dot 97 (0 center dot 58-1 center dot 63) 3rd vs. reference] nor self-reported diabetes [1 center dot 12 (0 center dot 80-1 center dot 58)] were associated with an increased risk of a first VT.",

keywords = "HYPERGLYCEMIA, MELLITUS, METAANALYSIS, THROMBOEMBOLISM, case-control studies, hyperglycaemia, odds ratio, type 2 diabetes mellitus, venous thrombosis",

author = "Ruifang Li-Gao and Morelli, {V{\^a}nia M.} and Lijfering, {Willem M.} and Cannegieter, {Suzanne C.} and Rosendaal, {Frits R.} and Vlieg, {Astrid van Hylckama}",

year = "2019",

doi = "10.1111/bjh.15599",

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T1 - Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case-control study

AU - Li-Gao, Ruifang

AU - Morelli, Vânia M.

AU - Lijfering, Willem M.

AU - Cannegieter, Suzanne C.

AU - Rosendaal, Frits R.

AU - Vlieg, Astrid van Hylckama

PY - 2019

Y1 - 2019

N2 - It is unclear whether hyperglycaemia or diabetes mellitus are risk factors for a first venous thrombosis (VT). Self-reported diabetes status and fasting glucose (FG) measures were collected from the Multiple Environmental and Genetic Assessment (MEGA) study to confirm these associations. FG levels were categorized based on the World Health Organization criteria [= 7 center dot 0 (3rd) mmol/l]. Logistic regression was performed to quantify the associations. Neither increased FG levels [Odds ratio (95% confidence interval): 0 center dot 98 (0 center dot 69-1 center dot 37) 2nd vs. reference, 0 center dot 97 (0 center dot 58-1 center dot 63) 3rd vs. reference] nor self-reported diabetes [1 center dot 12 (0 center dot 80-1 center dot 58)] were associated with an increased risk of a first VT.

AB - It is unclear whether hyperglycaemia or diabetes mellitus are risk factors for a first venous thrombosis (VT). Self-reported diabetes status and fasting glucose (FG) measures were collected from the Multiple Environmental and Genetic Assessment (MEGA) study to confirm these associations. FG levels were categorized based on the World Health Organization criteria [= 7 center dot 0 (3rd) mmol/l]. Logistic regression was performed to quantify the associations. Neither increased FG levels [Odds ratio (95% confidence interval): 0 center dot 98 (0 center dot 69-1 center dot 37) 2nd vs. reference, 0 center dot 97 (0 center dot 58-1 center dot 63) 3rd vs. reference] nor self-reported diabetes [1 center dot 12 (0 center dot 80-1 center dot 58)] were associated with an increased risk of a first VT.

KW - HYPERGLYCEMIA

KW - MELLITUS

KW - METAANALYSIS

KW - THROMBOEMBOLISM

KW - case-control studies

KW - hyperglycaemia

KW - odds ratio

KW - type 2 diabetes mellitus

KW - venous thrombosis

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JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 3

ER -

Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case-control study

Abstract

Keywords

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