Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre-and post-bright light therapy: First explorations.

P.C.M. Hamers; M. Savas; E. F. C. van Rossum; Y. B. de Rijke; P. J. E. Bindels; D. A. M. Festen; H. Hermans

Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre-and post-bright light therapy: First explorations.

P.C.M. Hamers^*, M. Savas, E. F. C. van Rossum, Y. B. de Rijke, P. J. E. Bindels , D. A. M. Festen, H. Hermans

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

BACKGROUND: Depressive symptoms and stress are common in adults with intellectual disabilities. Our aim was to explore long-term biological stress levels, assessed by hair cortisol (HairF) and cortisone (HairE) concentrations, in adults with intellectual disabilities and depressive symptoms and to investigate the effects of bright light therapy (BLT) on hair glucocorticoids.

METHOD: Scalp hair samples (n = 14) were retrospectively examined at baseline and post-BLT (10.000 and 300 lux). Liquid chromatography-tandem mass spectrometry was used to measure hair glucocorticoids.

RESULTS: A significant correlation was found between baseline HairF and depression scores (r = .605, p = .028). Post-intervention HairE levels were significantly increased ([95% CI: 11.2-17.4 pg/mg], p = .003), in particular after dim light (300 lux) ([95% CI: 10.0-18.3 pg/mg], p = .020).

CONCLUSIONS: This study showed that retrospectively examining biological levels of stress in adults with intellectual disabilities seems a potentially promising and objective method to gain insight in the stress level of adults with intellectual disabilities.

Original language	English
Pages (from-to)	1549-1559
Number of pages	11
Journal	Journal of Applied Research in Intellectual Disabilities
Volume	34
Issue number	6
Publication status	Published - 2021
Externally published	Yes

Keywords

Bright light therapy
Cortisol
Cortison
Depression
Intellectual disabilities
Long‐term stress

Cite this

@article{16efd9602f1141c2ba9531a81e50cc01,

title = "Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre-and post-bright light therapy: First explorations.",

abstract = "BACKGROUND: Depressive symptoms and stress are common in adults with intellectual disabilities. Our aim was to explore long-term biological stress levels, assessed by hair cortisol (HairF) and cortisone (HairE) concentrations, in adults with intellectual disabilities and depressive symptoms and to investigate the effects of bright light therapy (BLT) on hair glucocorticoids.METHOD: Scalp hair samples (n = 14) were retrospectively examined at baseline and post-BLT (10.000 and 300 lux). Liquid chromatography-tandem mass spectrometry was used to measure hair glucocorticoids.RESULTS: A significant correlation was found between baseline HairF and depression scores (r = .605, p = .028). Post-intervention HairE levels were significantly increased ([95% CI: 11.2-17.4 pg/mg], p = .003), in particular after dim light (300 lux) ([95% CI: 10.0-18.3 pg/mg], p = .020).CONCLUSIONS: This study showed that retrospectively examining biological levels of stress in adults with intellectual disabilities seems a potentially promising and objective method to gain insight in the stress level of adults with intellectual disabilities.",

keywords = "Bright light therapy, Cortisol, Cortison, Depression, Intellectual disabilities, Long‐term stress",

author = "P.C.M. Hamers and M. Savas and {van Rossum}, {E. F. C.} and {de Rijke}, {Y. B.} and Bindels, {P. J. E.} and Festen, {D. A. M.} and H. Hermans",

year = "2021",

language = "English",

volume = "34",

pages = "1549--1559",

journal = "Journal of Applied Research in Intellectual Disabilities",

issn = "1360-2322",

publisher = "Wiley-Blackwell",

number = "6",

}

Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre-and post-bright light therapy: First explorations. / Hamers, P.C.M.; Savas, M.; van Rossum, E. F. C. et al.
In: Journal of Applied Research in Intellectual Disabilities, Vol. 34, No. 6, 2021, p. 1549-1559.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre-and post-bright light therapy: First explorations.

AU - Hamers, P.C.M.

AU - Savas, M.

AU - van Rossum, E. F. C.

AU - de Rijke, Y. B.

AU - Bindels , P. J. E.

AU - Festen, D. A. M.

AU - Hermans, H.

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Depressive symptoms and stress are common in adults with intellectual disabilities. Our aim was to explore long-term biological stress levels, assessed by hair cortisol (HairF) and cortisone (HairE) concentrations, in adults with intellectual disabilities and depressive symptoms and to investigate the effects of bright light therapy (BLT) on hair glucocorticoids.METHOD: Scalp hair samples (n = 14) were retrospectively examined at baseline and post-BLT (10.000 and 300 lux). Liquid chromatography-tandem mass spectrometry was used to measure hair glucocorticoids.RESULTS: A significant correlation was found between baseline HairF and depression scores (r = .605, p = .028). Post-intervention HairE levels were significantly increased ([95% CI: 11.2-17.4 pg/mg], p = .003), in particular after dim light (300 lux) ([95% CI: 10.0-18.3 pg/mg], p = .020).CONCLUSIONS: This study showed that retrospectively examining biological levels of stress in adults with intellectual disabilities seems a potentially promising and objective method to gain insight in the stress level of adults with intellectual disabilities.

AB - BACKGROUND: Depressive symptoms and stress are common in adults with intellectual disabilities. Our aim was to explore long-term biological stress levels, assessed by hair cortisol (HairF) and cortisone (HairE) concentrations, in adults with intellectual disabilities and depressive symptoms and to investigate the effects of bright light therapy (BLT) on hair glucocorticoids.METHOD: Scalp hair samples (n = 14) were retrospectively examined at baseline and post-BLT (10.000 and 300 lux). Liquid chromatography-tandem mass spectrometry was used to measure hair glucocorticoids.RESULTS: A significant correlation was found between baseline HairF and depression scores (r = .605, p = .028). Post-intervention HairE levels were significantly increased ([95% CI: 11.2-17.4 pg/mg], p = .003), in particular after dim light (300 lux) ([95% CI: 10.0-18.3 pg/mg], p = .020).CONCLUSIONS: This study showed that retrospectively examining biological levels of stress in adults with intellectual disabilities seems a potentially promising and objective method to gain insight in the stress level of adults with intellectual disabilities.

KW - Bright light therapy

KW - Cortisol

KW - Cortison

KW - Depression

KW - Intellectual disabilities

KW - Long‐term stress

M3 - Article

SN - 1360-2322

VL - 34

SP - 1549

EP - 1559

JO - Journal of Applied Research in Intellectual Disabilities

JF - Journal of Applied Research in Intellectual Disabilities

IS - 6

ER -

Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre-and post-bright light therapy: First explorations.

Abstract

Keywords

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