TY - JOUR
T1 - Health-related quality of life after Gamma Knife radiosurgery in patients with 1–10 brain metastases
AU - Verhaak, Eline
AU - Schimmel, Wietske C. M.
AU - Gehring, Karin
AU - Emons, Wilco H. M.
AU - Hanssens, Patrick E. J.
AU - Sitskoorn, Margriet M.
N1 - Funding
This study was funded by ZonMw, the Netherlands organization for health research and development (Project Number 842003008).
Eline Verhaak and Wietske C. M. Schimmel share co-first authorship.
PY - 2021
Y1 - 2021
N2 - Purpose: Increasingly more patients with multiple (> 4) brain metastases (BM) are being treated with stereotactic radiosurgery (SRS). Preserving patients’ health-related quality of life (HRQoL) is an important treatment goal. The aim of this study was to assess (individual) changes in HRQoL in patients with 1–10 BM over time. Methods: A total of 92 patients were assessed before (n = 92) and at 3 (n = 66), 6 (n = 53), and 9 (n = 41) months after Gamma Knife radiosurgery (GKRS), using the Functional Assessment of Cancer Therapy-Brain (FACT-Br). The course of HRQoL was analyzed using linear mixed models. Clinical minimally important differences were used to evaluate individual changes. Results: At group level, patients’ physical well-being worsened, whereas emotional well-being improved over 9 months. Scores on other HRQoL subscales did not change significantly. Number (1–3 versus 4–10) and volume (small, medium, and large) of BM did not influence HRQoL over time, except for the subscale additional concerns; medium intracranial tumor volume was associated with less additional concerns. On the individual level as well, physical well-being declined while emotional well-being improved in most patients over 9 months after GKRS. At patient level, however, most patients had both declines as well as improvements in the different HRQoL aspects. Conclusion: Our results indicate that even in patients with up to 10 BM, both at group and individual subscale level, aspects of HRQoL remained stable over nine months after GKRS, except for an improvement in emotional well-being and a decline in physical well-being. Nevertheless, HRQoL scores varied considerably at the individual patient level. Trail registration number: ClinicalTrials.gov Identifier: NCT02953756, November 3, 2016.
AB - Purpose: Increasingly more patients with multiple (> 4) brain metastases (BM) are being treated with stereotactic radiosurgery (SRS). Preserving patients’ health-related quality of life (HRQoL) is an important treatment goal. The aim of this study was to assess (individual) changes in HRQoL in patients with 1–10 BM over time. Methods: A total of 92 patients were assessed before (n = 92) and at 3 (n = 66), 6 (n = 53), and 9 (n = 41) months after Gamma Knife radiosurgery (GKRS), using the Functional Assessment of Cancer Therapy-Brain (FACT-Br). The course of HRQoL was analyzed using linear mixed models. Clinical minimally important differences were used to evaluate individual changes. Results: At group level, patients’ physical well-being worsened, whereas emotional well-being improved over 9 months. Scores on other HRQoL subscales did not change significantly. Number (1–3 versus 4–10) and volume (small, medium, and large) of BM did not influence HRQoL over time, except for the subscale additional concerns; medium intracranial tumor volume was associated with less additional concerns. On the individual level as well, physical well-being declined while emotional well-being improved in most patients over 9 months after GKRS. At patient level, however, most patients had both declines as well as improvements in the different HRQoL aspects. Conclusion: Our results indicate that even in patients with up to 10 BM, both at group and individual subscale level, aspects of HRQoL remained stable over nine months after GKRS, except for an improvement in emotional well-being and a decline in physical well-being. Nevertheless, HRQoL scores varied considerably at the individual patient level. Trail registration number: ClinicalTrials.gov Identifier: NCT02953756, November 3, 2016.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Brain Neoplasms/secondary
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Longitudinal Studies
KW - Male
KW - Middle Aged
KW - Neoplasms/pathology
KW - Prognosis
KW - Prospective Studies
KW - Quality of Life
KW - Radiosurgery/mortality
KW - Survival Rate
UR - http://www.scopus.com/inward/record.url?scp=85092089095&partnerID=8YFLogxK
UR - https://clinicaltrials.gov/ct2/show/NCT02953756
U2 - 10.1007/s00432-020-03400-w
DO - 10.1007/s00432-020-03400-w
M3 - Article
C2 - 33025282
SN - 0171-5216
VL - 147
SP - 1157
EP - 1167
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
IS - 4
ER -