Health related quality of life among cancer patients in their last year of life

Results from the PROFILES registry

N.J.H. Raijmakers, M. Zijlstra, J. van Roij, O. Husson, S. Oerlemans, L.V. van de Poll-Franse

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Purpose
The aim of this study was to assess health-related quality of life (HRQoL) in the last year of life of cancer patients stratified by four periods of time before death.
Patients and methods
Between 2008 and 2015, cancer patients were invited to participate in PROFILES (Patient Reported Outcomes Following Initial Treatment and Long-term Evaluation of Survivorship) registry studies. Patients were eligible for inclusion in this secondary analysis if they had been invited to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) in their last year of life (N = 892). Four hundred fifty-eight patients (51%) responded. Descriptive statistics were used to describe the HRQoL of cancer patients in the last 3 months of life (N = 61), the last 3-6 months (N = 110), the last 6-9 months (N = 138), or the last 9-12 months of their life (N = 129).
Results
Patients in the last 3 months report a significant lower HRQoL, lower functioning, and higher symptom burden of fatigue and appetite loss compared to patients in different time periods before death (p < 0.008). Clinical relevance of the differences for global QoL, cognitive, and social functioning was large. Patients' HRQoL in the last year of life was significantly lower than that of the normative population (p < 0.001).
Conclusions
All aspects of HRQoL are considerably impaired in patients with advanced cancer, with a marked lower HRQoL in the final months of life. This marked decline of HRQoL in the final months of life may be an indicator of approaching death and serve as an important trigger for end-of-life communication and decision-making about subsequent treatment and supportive care
Original languageEnglish
Pages (from-to)3397–3404
JournalSupportive Care in Cancer
Volume26
Issue number10
DOIs
Publication statusPublished - 2018

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Survival Rate
Neoplasms
Communication
Organizations

Keywords

  • Advanced cancer
  • PALLIATIVE CARE
  • Palliative care
  • Population-based cohort
  • QLQ-C30
  • QUESTIONNAIRE
  • Quality of life
  • REPORTED OUTCOMES
  • VALIDATION

Cite this

@article{6211e3a4ad274de3a635fddf4539c41f,
title = "Health related quality of life among cancer patients in their last year of life: Results from the PROFILES registry",
abstract = "PurposeThe aim of this study was to assess health-related quality of life (HRQoL) in the last year of life of cancer patients stratified by four periods of time before death.Patients and methodsBetween 2008 and 2015, cancer patients were invited to participate in PROFILES (Patient Reported Outcomes Following Initial Treatment and Long-term Evaluation of Survivorship) registry studies. Patients were eligible for inclusion in this secondary analysis if they had been invited to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) in their last year of life (N = 892). Four hundred fifty-eight patients (51{\%}) responded. Descriptive statistics were used to describe the HRQoL of cancer patients in the last 3 months of life (N = 61), the last 3-6 months (N = 110), the last 6-9 months (N = 138), or the last 9-12 months of their life (N = 129).ResultsPatients in the last 3 months report a significant lower HRQoL, lower functioning, and higher symptom burden of fatigue and appetite loss compared to patients in different time periods before death (p < 0.008). Clinical relevance of the differences for global QoL, cognitive, and social functioning was large. Patients' HRQoL in the last year of life was significantly lower than that of the normative population (p < 0.001).ConclusionsAll aspects of HRQoL are considerably impaired in patients with advanced cancer, with a marked lower HRQoL in the final months of life. This marked decline of HRQoL in the final months of life may be an indicator of approaching death and serve as an important trigger for end-of-life communication and decision-making about subsequent treatment and supportive care",
keywords = "Advanced cancer, PALLIATIVE CARE, Palliative care, Population-based cohort, QLQ-C30, QUESTIONNAIRE, Quality of life, REPORTED OUTCOMES, VALIDATION",
author = "N.J.H. Raijmakers and M. Zijlstra and {van Roij}, J. and O. Husson and S. Oerlemans and {van de Poll-Franse}, L.V.",
year = "2018",
doi = "10.1007/s00520-018-4181-6",
language = "English",
volume = "26",
pages = "3397–3404",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer",
number = "10",

}

Health related quality of life among cancer patients in their last year of life : Results from the PROFILES registry. / Raijmakers, N.J.H.; Zijlstra, M.; van Roij, J.; Husson, O.; Oerlemans, S.; van de Poll-Franse, L.V.

In: Supportive Care in Cancer, Vol. 26, No. 10, 2018, p. 3397–3404.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Health related quality of life among cancer patients in their last year of life

T2 - Results from the PROFILES registry

AU - Raijmakers, N.J.H.

AU - Zijlstra, M.

AU - van Roij, J.

AU - Husson, O.

AU - Oerlemans, S.

AU - van de Poll-Franse, L.V.

PY - 2018

Y1 - 2018

N2 - PurposeThe aim of this study was to assess health-related quality of life (HRQoL) in the last year of life of cancer patients stratified by four periods of time before death.Patients and methodsBetween 2008 and 2015, cancer patients were invited to participate in PROFILES (Patient Reported Outcomes Following Initial Treatment and Long-term Evaluation of Survivorship) registry studies. Patients were eligible for inclusion in this secondary analysis if they had been invited to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) in their last year of life (N = 892). Four hundred fifty-eight patients (51%) responded. Descriptive statistics were used to describe the HRQoL of cancer patients in the last 3 months of life (N = 61), the last 3-6 months (N = 110), the last 6-9 months (N = 138), or the last 9-12 months of their life (N = 129).ResultsPatients in the last 3 months report a significant lower HRQoL, lower functioning, and higher symptom burden of fatigue and appetite loss compared to patients in different time periods before death (p < 0.008). Clinical relevance of the differences for global QoL, cognitive, and social functioning was large. Patients' HRQoL in the last year of life was significantly lower than that of the normative population (p < 0.001).ConclusionsAll aspects of HRQoL are considerably impaired in patients with advanced cancer, with a marked lower HRQoL in the final months of life. This marked decline of HRQoL in the final months of life may be an indicator of approaching death and serve as an important trigger for end-of-life communication and decision-making about subsequent treatment and supportive care

AB - PurposeThe aim of this study was to assess health-related quality of life (HRQoL) in the last year of life of cancer patients stratified by four periods of time before death.Patients and methodsBetween 2008 and 2015, cancer patients were invited to participate in PROFILES (Patient Reported Outcomes Following Initial Treatment and Long-term Evaluation of Survivorship) registry studies. Patients were eligible for inclusion in this secondary analysis if they had been invited to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) in their last year of life (N = 892). Four hundred fifty-eight patients (51%) responded. Descriptive statistics were used to describe the HRQoL of cancer patients in the last 3 months of life (N = 61), the last 3-6 months (N = 110), the last 6-9 months (N = 138), or the last 9-12 months of their life (N = 129).ResultsPatients in the last 3 months report a significant lower HRQoL, lower functioning, and higher symptom burden of fatigue and appetite loss compared to patients in different time periods before death (p < 0.008). Clinical relevance of the differences for global QoL, cognitive, and social functioning was large. Patients' HRQoL in the last year of life was significantly lower than that of the normative population (p < 0.001).ConclusionsAll aspects of HRQoL are considerably impaired in patients with advanced cancer, with a marked lower HRQoL in the final months of life. This marked decline of HRQoL in the final months of life may be an indicator of approaching death and serve as an important trigger for end-of-life communication and decision-making about subsequent treatment and supportive care

KW - Advanced cancer

KW - PALLIATIVE CARE

KW - Palliative care

KW - Population-based cohort

KW - QLQ-C30

KW - QUESTIONNAIRE

KW - Quality of life

KW - REPORTED OUTCOMES

KW - VALIDATION

U2 - 10.1007/s00520-018-4181-6

DO - 10.1007/s00520-018-4181-6

M3 - Article

VL - 26

SP - 3397

EP - 3404

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 10

ER -