Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: A systematic, narrative review

Eline Verhaak, Karin Gehring*, Patrick E. J. Hanssens, Neil K. Aaronson, Margriet M. Sitskoorn

*Corresponding author for this work

Research output: Contribution to journalReview articleScientificpeer-review

Abstract

Purpose
A growing number of patients with brain metastases (BM) are being treated with stereotactic radiosurgery (SRS), and the importance of evaluating the impact of SRS on the health-related quality of life (HRQoL) in these patients has been increasingly acknowledged. This systematic review summarizes the current knowledge about the HRQoL of patients with BM after SRS.

Methods
We searched EMBASE, Medline Ovid, Web-of-Science, the Cochrane Database, PsycINFO Ovid, and Google Scholar up to November 15, 2018. Studies in patients with BM in which HRQoL was assessed before and after SRS and analyzed over time were included. Studies including populations of several types of brain cancer and/or several types of treatments were included if the results for patients with BM and treatment with SRS alone were described separately.

Results
Out of 3638 published articles, 9 studies met the eligibility criteria and were included. In 4 out of 7 studies on group results, overall HRQoL of patients with BM remained stable after SRS. In small study samples of longer-term survivors, overall HRQoL remained stable up to 12 months post-SRS. Contradictory results were reported for physical and general/global HRQoL, which might be explained by the different questionnaires that were used.

Conclusions
In general, SRS does not have significant negative effects on patients’ overall HRQoL over time. Future research is needed to analyze different aspects of HRQoL, differences in individual changes in HRQoL after SRS, and factors that influence these changes. These studies should take into account several methodological issues as discussed in this review.
Original languageEnglish
Pages (from-to)473-484
JournalSupportive Care in Cancer
Volume28
DOIs
Publication statusPublished - 2019

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Radiosurgery
Individuality
Survivors
Databases

Keywords

  • Brain metastases
  • CANCER
  • Cancer
  • EORTC QLQ-BN20
  • EPIDEMIOLOGY
  • GAMMA-KNIFE RADIOSURGERY
  • Health-related quality of life
  • IRRADIATION
  • MANAGEMENT
  • Neoplasm metastasis
  • PATIENTS RECEIVING TREATMENT
  • Patient-reported outcome measures
  • RADIOTHERAPY
  • Radiosurgery
  • SINGLE
  • TRIALS

Cite this

@article{f3e7f011a6c847078690be8fbe851e4e,
title = "Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: A systematic, narrative review",
abstract = "PurposeA growing number of patients with brain metastases (BM) are being treated with stereotactic radiosurgery (SRS), and the importance of evaluating the impact of SRS on the health-related quality of life (HRQoL) in these patients has been increasingly acknowledged. This systematic review summarizes the current knowledge about the HRQoL of patients with BM after SRS.MethodsWe searched EMBASE, Medline Ovid, Web-of-Science, the Cochrane Database, PsycINFO Ovid, and Google Scholar up to November 15, 2018. Studies in patients with BM in which HRQoL was assessed before and after SRS and analyzed over time were included. Studies including populations of several types of brain cancer and/or several types of treatments were included if the results for patients with BM and treatment with SRS alone were described separately.ResultsOut of 3638 published articles, 9 studies met the eligibility criteria and were included. In 4 out of 7 studies on group results, overall HRQoL of patients with BM remained stable after SRS. In small study samples of longer-term survivors, overall HRQoL remained stable up to 12 months post-SRS. Contradictory results were reported for physical and general/global HRQoL, which might be explained by the different questionnaires that were used.ConclusionsIn general, SRS does not have significant negative effects on patients’ overall HRQoL over time. Future research is needed to analyze different aspects of HRQoL, differences in individual changes in HRQoL after SRS, and factors that influence these changes. These studies should take into account several methodological issues as discussed in this review.",
keywords = "Brain metastases, CANCER, Cancer, EORTC QLQ-BN20, EPIDEMIOLOGY, GAMMA-KNIFE RADIOSURGERY, Health-related quality of life, IRRADIATION, MANAGEMENT, Neoplasm metastasis, PATIENTS RECEIVING TREATMENT, Patient-reported outcome measures, RADIOTHERAPY, Radiosurgery, SINGLE, TRIALS",
author = "Eline Verhaak and Karin Gehring and Hanssens, {Patrick E. J.} and Aaronson, {Neil K.} and Sitskoorn, {Margriet M.}",
year = "2019",
doi = "10.1007/s00520-019-05136-x",
language = "English",
volume = "28",
pages = "473--484",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer",

}

Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery : A systematic, narrative review. / Verhaak, Eline; Gehring, Karin; Hanssens, Patrick E. J.; Aaronson, Neil K.; Sitskoorn, Margriet M.

In: Supportive Care in Cancer, Vol. 28, 2019, p. 473-484.

Research output: Contribution to journalReview articleScientificpeer-review

TY - JOUR

T1 - Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery

T2 - A systematic, narrative review

AU - Verhaak, Eline

AU - Gehring, Karin

AU - Hanssens, Patrick E. J.

AU - Aaronson, Neil K.

AU - Sitskoorn, Margriet M.

PY - 2019

Y1 - 2019

N2 - PurposeA growing number of patients with brain metastases (BM) are being treated with stereotactic radiosurgery (SRS), and the importance of evaluating the impact of SRS on the health-related quality of life (HRQoL) in these patients has been increasingly acknowledged. This systematic review summarizes the current knowledge about the HRQoL of patients with BM after SRS.MethodsWe searched EMBASE, Medline Ovid, Web-of-Science, the Cochrane Database, PsycINFO Ovid, and Google Scholar up to November 15, 2018. Studies in patients with BM in which HRQoL was assessed before and after SRS and analyzed over time were included. Studies including populations of several types of brain cancer and/or several types of treatments were included if the results for patients with BM and treatment with SRS alone were described separately.ResultsOut of 3638 published articles, 9 studies met the eligibility criteria and were included. In 4 out of 7 studies on group results, overall HRQoL of patients with BM remained stable after SRS. In small study samples of longer-term survivors, overall HRQoL remained stable up to 12 months post-SRS. Contradictory results were reported for physical and general/global HRQoL, which might be explained by the different questionnaires that were used.ConclusionsIn general, SRS does not have significant negative effects on patients’ overall HRQoL over time. Future research is needed to analyze different aspects of HRQoL, differences in individual changes in HRQoL after SRS, and factors that influence these changes. These studies should take into account several methodological issues as discussed in this review.

AB - PurposeA growing number of patients with brain metastases (BM) are being treated with stereotactic radiosurgery (SRS), and the importance of evaluating the impact of SRS on the health-related quality of life (HRQoL) in these patients has been increasingly acknowledged. This systematic review summarizes the current knowledge about the HRQoL of patients with BM after SRS.MethodsWe searched EMBASE, Medline Ovid, Web-of-Science, the Cochrane Database, PsycINFO Ovid, and Google Scholar up to November 15, 2018. Studies in patients with BM in which HRQoL was assessed before and after SRS and analyzed over time were included. Studies including populations of several types of brain cancer and/or several types of treatments were included if the results for patients with BM and treatment with SRS alone were described separately.ResultsOut of 3638 published articles, 9 studies met the eligibility criteria and were included. In 4 out of 7 studies on group results, overall HRQoL of patients with BM remained stable after SRS. In small study samples of longer-term survivors, overall HRQoL remained stable up to 12 months post-SRS. Contradictory results were reported for physical and general/global HRQoL, which might be explained by the different questionnaires that were used.ConclusionsIn general, SRS does not have significant negative effects on patients’ overall HRQoL over time. Future research is needed to analyze different aspects of HRQoL, differences in individual changes in HRQoL after SRS, and factors that influence these changes. These studies should take into account several methodological issues as discussed in this review.

KW - Brain metastases

KW - CANCER

KW - Cancer

KW - EORTC QLQ-BN20

KW - EPIDEMIOLOGY

KW - GAMMA-KNIFE RADIOSURGERY

KW - Health-related quality of life

KW - IRRADIATION

KW - MANAGEMENT

KW - Neoplasm metastasis

KW - PATIENTS RECEIVING TREATMENT

KW - Patient-reported outcome measures

KW - RADIOTHERAPY

KW - Radiosurgery

KW - SINGLE

KW - TRIALS

U2 - 10.1007/s00520-019-05136-x

DO - 10.1007/s00520-019-05136-x

M3 - Review article

C2 - 31792879

VL - 28

SP - 473

EP - 484

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

ER -