Health-related quality of life is associated with physical activity levels among colorectal cancer survivors: A longitudinal, 3-year study of the PROFILES registry

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Abstract

Purpose
The present study aims to examine the longitudinal relation between physical activity (PA) and health-related quality of life (HRQoL) among colorectal cancer (CRC) survivors.
Methods
Individuals diagnosed with CRC between 2000 and 2009 as registered by the Dutch population-based Eindhoven Cancer Registry, and who were eligible for the study, received a questionnaire on three time points with 1-year intervals. Generalized linear mixed models were used to estimate the independent effects of PA on HRQoL over time.
Results
Response rates were 73 % (n = 2625), 83 % (n = 1643), and 82 % (n = 1458) at T1, T2, and T3, respectively. PA behavior was relatively stable over time with 82 % of the patients meeting the Dutch PA guidelines (at least 150 min of moderate to vigorous PA per week) at all assessment periods. Multivariate analyses showed that patients who met the PA guidelines scored, on average, 13.7 points higher on the global quality of life, 26.0 on physical, 24.2 on role, 9.0 on cognitive, 10.4 on emotional, and 14.8 on social functioning over time compared to patients not meeting the guidelines (interindividual effects; all p < 0.01). Small intraindividual effects were found for physical (2.9) and role functioning (4.0) and global quality of life (2.1), indicating that patients who went from not meeting to meeting the guidelines over time improved on these scales (p < 0.05).
Conclusion
There is a substantial positive association between PA and HRQoL, which is consistent over time for CRC survivors >2 years since diagnosis.Implications for Cancer SurvivorsOur results underline the importance to focus upon training in survivorship care and strategies to get inactive cancer survivors physically active.Keywords: Colorectal cancer, Health-related quality of life, Physical activity, Exercise, Cancer survivor
Original languageEnglish
Pages (from-to)472-480
JournalJournal of Cancer Survivorship
Volume9
Issue number3
DOIs
Publication statusPublished - 2015

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Survivors
Exercise
Neoplasms
Linear Models
Multivariate Analysis
Survival Rate

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@article{a49f1e7ee54c463fb5f4114b7563fab6,
title = "Health-related quality of life is associated with physical activity levels among colorectal cancer survivors: A longitudinal, 3-year study of the PROFILES registry",
abstract = "PurposeThe present study aims to examine the longitudinal relation between physical activity (PA) and health-related quality of life (HRQoL) among colorectal cancer (CRC) survivors.MethodsIndividuals diagnosed with CRC between 2000 and 2009 as registered by the Dutch population-based Eindhoven Cancer Registry, and who were eligible for the study, received a questionnaire on three time points with 1-year intervals. Generalized linear mixed models were used to estimate the independent effects of PA on HRQoL over time.ResultsResponse rates were 73 {\%} (n = 2625), 83 {\%} (n = 1643), and 82 {\%} (n = 1458) at T1, T2, and T3, respectively. PA behavior was relatively stable over time with 82 {\%} of the patients meeting the Dutch PA guidelines (at least 150 min of moderate to vigorous PA per week) at all assessment periods. Multivariate analyses showed that patients who met the PA guidelines scored, on average, 13.7 points higher on the global quality of life, 26.0 on physical, 24.2 on role, 9.0 on cognitive, 10.4 on emotional, and 14.8 on social functioning over time compared to patients not meeting the guidelines (interindividual effects; all p < 0.01). Small intraindividual effects were found for physical (2.9) and role functioning (4.0) and global quality of life (2.1), indicating that patients who went from not meeting to meeting the guidelines over time improved on these scales (p < 0.05).ConclusionThere is a substantial positive association between PA and HRQoL, which is consistent over time for CRC survivors >2 years since diagnosis.Implications for Cancer SurvivorsOur results underline the importance to focus upon training in survivorship care and strategies to get inactive cancer survivors physically active.Keywords: Colorectal cancer, Health-related quality of life, Physical activity, Exercise, Cancer survivor",
author = "O. Husson and F. Mols and N.P.M. Ezendam and G. Schep and {van de Poll-Franse}, L.V.",
year = "2015",
doi = "10.1007/s11764-014-0423-x",
language = "English",
volume = "9",
pages = "472--480",
journal = "Journal of Cancer Survivorship",
issn = "1932-2259",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Health-related quality of life is associated with physical activity levels among colorectal cancer survivors

T2 - A longitudinal, 3-year study of the PROFILES registry

AU - Husson, O.

AU - Mols, F.

AU - Ezendam, N.P.M.

AU - Schep, G.

AU - van de Poll-Franse, L.V.

PY - 2015

Y1 - 2015

N2 - PurposeThe present study aims to examine the longitudinal relation between physical activity (PA) and health-related quality of life (HRQoL) among colorectal cancer (CRC) survivors.MethodsIndividuals diagnosed with CRC between 2000 and 2009 as registered by the Dutch population-based Eindhoven Cancer Registry, and who were eligible for the study, received a questionnaire on three time points with 1-year intervals. Generalized linear mixed models were used to estimate the independent effects of PA on HRQoL over time.ResultsResponse rates were 73 % (n = 2625), 83 % (n = 1643), and 82 % (n = 1458) at T1, T2, and T3, respectively. PA behavior was relatively stable over time with 82 % of the patients meeting the Dutch PA guidelines (at least 150 min of moderate to vigorous PA per week) at all assessment periods. Multivariate analyses showed that patients who met the PA guidelines scored, on average, 13.7 points higher on the global quality of life, 26.0 on physical, 24.2 on role, 9.0 on cognitive, 10.4 on emotional, and 14.8 on social functioning over time compared to patients not meeting the guidelines (interindividual effects; all p < 0.01). Small intraindividual effects were found for physical (2.9) and role functioning (4.0) and global quality of life (2.1), indicating that patients who went from not meeting to meeting the guidelines over time improved on these scales (p < 0.05).ConclusionThere is a substantial positive association between PA and HRQoL, which is consistent over time for CRC survivors >2 years since diagnosis.Implications for Cancer SurvivorsOur results underline the importance to focus upon training in survivorship care and strategies to get inactive cancer survivors physically active.Keywords: Colorectal cancer, Health-related quality of life, Physical activity, Exercise, Cancer survivor

AB - PurposeThe present study aims to examine the longitudinal relation between physical activity (PA) and health-related quality of life (HRQoL) among colorectal cancer (CRC) survivors.MethodsIndividuals diagnosed with CRC between 2000 and 2009 as registered by the Dutch population-based Eindhoven Cancer Registry, and who were eligible for the study, received a questionnaire on three time points with 1-year intervals. Generalized linear mixed models were used to estimate the independent effects of PA on HRQoL over time.ResultsResponse rates were 73 % (n = 2625), 83 % (n = 1643), and 82 % (n = 1458) at T1, T2, and T3, respectively. PA behavior was relatively stable over time with 82 % of the patients meeting the Dutch PA guidelines (at least 150 min of moderate to vigorous PA per week) at all assessment periods. Multivariate analyses showed that patients who met the PA guidelines scored, on average, 13.7 points higher on the global quality of life, 26.0 on physical, 24.2 on role, 9.0 on cognitive, 10.4 on emotional, and 14.8 on social functioning over time compared to patients not meeting the guidelines (interindividual effects; all p < 0.01). Small intraindividual effects were found for physical (2.9) and role functioning (4.0) and global quality of life (2.1), indicating that patients who went from not meeting to meeting the guidelines over time improved on these scales (p < 0.05).ConclusionThere is a substantial positive association between PA and HRQoL, which is consistent over time for CRC survivors >2 years since diagnosis.Implications for Cancer SurvivorsOur results underline the importance to focus upon training in survivorship care and strategies to get inactive cancer survivors physically active.Keywords: Colorectal cancer, Health-related quality of life, Physical activity, Exercise, Cancer survivor

UR - http://hdl.handle.net/10411/20596

U2 - 10.1007/s11764-014-0423-x

DO - 10.1007/s11764-014-0423-x

M3 - Article

VL - 9

SP - 472

EP - 480

JO - Journal of Cancer Survivorship

JF - Journal of Cancer Survivorship

SN - 1932-2259

IS - 3

ER -