Heritable changes in regional cortical thickness with age

Francois Chouinard-Decorte; D. Reese McKay; Andrew Reid; Budhachandra Khundrakpam; Lu Zhao; Sherif Karama; Pierre Rioux; Emma Sprooten; Emma Knowles; Jack W. Kent; Joanne E. Curran; Harald H.H. Göring; Thomas D. Dyer; Rene L. Olvera; Peter Kochunov; Ravi Duggirala; Peter T. Fox; Laura Almasy; John Blangero; Pierre Bellec; Alan C. Evans; David C. Glahn

doi:10.1007/s11682-014-9296-x

Heritable changes in regional cortical thickness with age

Francois Chouinard-Decorte, D. Reese McKay, Andrew Reid, Budhachandra Khundrakpam, Lu Zhao, Sherif Karama, Pierre Rioux, Emma Sprooten, Emma Knowles, Jack W. Kent, Joanne E. Curran, Harald H.H. Göring, Thomas D. Dyer, Rene L. Olvera, Peter Kochunov, Ravi Duggirala, Peter T. Fox, Laura Almasy, John Blangero, Pierre BellecAlan C. Evans, David C. Glahn

Research output: Contribution to journal › Article › Scientific › peer-review

21 Citations (Scopus)

Abstract

It is now well established that regional indices of brain structure such as cortical thickness, surface area or grey matter volume exhibit spatially variable patterns of heritability. However, a recent study found these patterns to change with age during development, a result supported by gene expression studies. Changes in heritability have not been investigated in adulthood so far and could have important implications in the study of heritability and genetic correlations in the brain as well as in the discovery of specific genes explaining them. Herein, we tested for genotype by age (G ×A) interactions, an extension of genotype by environment interactions, through adulthood and healthy aging in 902 subjects from the Genetics of Brain Structure (GOBS) study. A "jackknife" based method for the analysis of stable cortical thickness clusters (JASC) and scale selection is also introduced. Although additive genetic variance remained constant throughout adulthood, we found evidence for incomplete pleiotropy across age in the cortical thickness of paralimbic and parieto-temporal areas. This suggests that different genetic factors account for cortical thickness heritability at different ages in these regions.

Original language	English
Pages (from-to)	208-216
Number of pages	9
Journal	Brain Imaging and Behavior
Volume	8
Issue number	2
DOIs	https://doi.org/10.1007/s11682-014-9296-x
Publication status	Published - Jun 2014
Externally published	Yes

Keywords

Clustering
Cortical Thickness
Genotype by Age Interaction
Heritability

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10.1007/s11682-014-9296-x

Cite this

Chouinard-Decorte, F., McKay, D. R., Reid, A., Khundrakpam, B., Zhao, L., Karama, S., Rioux, P., Sprooten, E., Knowles, E., Kent, J. W., Curran, J. E., Göring, H. H. H., Dyer, T. D., Olvera, R. L., Kochunov, P., Duggirala, R., Fox, P. T., Almasy, L., Blangero, J., ... Glahn, D. C. (2014). Heritable changes in regional cortical thickness with age. Brain Imaging and Behavior, 8(2), 208-216. https://doi.org/10.1007/s11682-014-9296-x

@article{abe2ffb3304c40b59fddbe784e1c1bd1,

title = "Heritable changes in regional cortical thickness with age",

abstract = "It is now well established that regional indices of brain structure such as cortical thickness, surface area or grey matter volume exhibit spatially variable patterns of heritability. However, a recent study found these patterns to change with age during development, a result supported by gene expression studies. Changes in heritability have not been investigated in adulthood so far and could have important implications in the study of heritability and genetic correlations in the brain as well as in the discovery of specific genes explaining them. Herein, we tested for genotype by age (G ×A) interactions, an extension of genotype by environment interactions, through adulthood and healthy aging in 902 subjects from the Genetics of Brain Structure (GOBS) study. A {"}jackknife{"} based method for the analysis of stable cortical thickness clusters (JASC) and scale selection is also introduced. Although additive genetic variance remained constant throughout adulthood, we found evidence for incomplete pleiotropy across age in the cortical thickness of paralimbic and parieto-temporal areas. This suggests that different genetic factors account for cortical thickness heritability at different ages in these regions.",

keywords = "Clustering, Cortical Thickness, Genotype by Age Interaction, Heritability",

author = "Francois Chouinard-Decorte and McKay, {D. Reese} and Andrew Reid and Budhachandra Khundrakpam and Lu Zhao and Sherif Karama and Pierre Rioux and Emma Sprooten and Emma Knowles and Kent, {Jack W.} and Curran, {Joanne E.} and G{\"o}ring, {Harald H.H.} and Dyer, {Thomas D.} and Olvera, {Rene L.} and Peter Kochunov and Ravi Duggirala and Fox, {Peter T.} and Laura Almasy and John Blangero and Pierre Bellec and Evans, {Alan C.} and Glahn, {David C.}",

note = "Funding Information: Acknowledgments Financial support for this study was provided by the National Institute of Mental Health grants MH0708143 (Principal Investigator [PI]: DCG), MH078111 (PI: JB), and MH083824 (PI: DCG & JB), Canadian Institutes of Health Research (CIHR) operating grant MOP 37754 (PI: ACE) and by the Natural Sciences and Engineering Research Council of Canada grant # 436141 (PI: PB). Theoretical development of the GxA model and its implementation in SOLAR is supported by National Institute of Mental Health Grant MH59490 (PI: JB). PB is supported by a salary award of the Fonds de recherche du Qu{\'e}bec - Sant{\'e} (FRQS). Authors declare no competing financial interests in relation to the described work.",

year = "2014",

month = jun,

doi = "10.1007/s11682-014-9296-x",

language = "English",

volume = "8",

pages = "208--216",

journal = "Brain Imaging and Behavior",

issn = "1931-7557",

publisher = "Springer New York",

number = "2",

}

Chouinard-Decorte, F, McKay, DR, Reid, A, Khundrakpam, B, Zhao, L, Karama, S, Rioux, P, Sprooten, E, Knowles, E, Kent, JW, Curran, JE, Göring, HHH, Dyer, TD, Olvera, RL, Kochunov, P, Duggirala, R, Fox, PT, Almasy, L, Blangero, J, Bellec, P, Evans, AC & Glahn, DC 2014, 'Heritable changes in regional cortical thickness with age', Brain Imaging and Behavior, vol. 8, no. 2, pp. 208-216. https://doi.org/10.1007/s11682-014-9296-x

TY - JOUR

T1 - Heritable changes in regional cortical thickness with age

AU - Chouinard-Decorte, Francois

AU - McKay, D. Reese

AU - Reid, Andrew

AU - Khundrakpam, Budhachandra

AU - Zhao, Lu

AU - Karama, Sherif

AU - Rioux, Pierre

AU - Sprooten, Emma

AU - Knowles, Emma

AU - Kent, Jack W.

AU - Curran, Joanne E.

AU - Göring, Harald H.H.

AU - Dyer, Thomas D.

AU - Olvera, Rene L.

AU - Kochunov, Peter

AU - Duggirala, Ravi

AU - Fox, Peter T.

AU - Almasy, Laura

AU - Blangero, John

AU - Bellec, Pierre

AU - Evans, Alan C.

AU - Glahn, David C.

N1 - Funding Information: Acknowledgments Financial support for this study was provided by the National Institute of Mental Health grants MH0708143 (Principal Investigator [PI]: DCG), MH078111 (PI: JB), and MH083824 (PI: DCG & JB), Canadian Institutes of Health Research (CIHR) operating grant MOP 37754 (PI: ACE) and by the Natural Sciences and Engineering Research Council of Canada grant # 436141 (PI: PB). Theoretical development of the GxA model and its implementation in SOLAR is supported by National Institute of Mental Health Grant MH59490 (PI: JB). PB is supported by a salary award of the Fonds de recherche du Québec - Santé (FRQS). Authors declare no competing financial interests in relation to the described work.

PY - 2014/6

Y1 - 2014/6

N2 - It is now well established that regional indices of brain structure such as cortical thickness, surface area or grey matter volume exhibit spatially variable patterns of heritability. However, a recent study found these patterns to change with age during development, a result supported by gene expression studies. Changes in heritability have not been investigated in adulthood so far and could have important implications in the study of heritability and genetic correlations in the brain as well as in the discovery of specific genes explaining them. Herein, we tested for genotype by age (G ×A) interactions, an extension of genotype by environment interactions, through adulthood and healthy aging in 902 subjects from the Genetics of Brain Structure (GOBS) study. A "jackknife" based method for the analysis of stable cortical thickness clusters (JASC) and scale selection is also introduced. Although additive genetic variance remained constant throughout adulthood, we found evidence for incomplete pleiotropy across age in the cortical thickness of paralimbic and parieto-temporal areas. This suggests that different genetic factors account for cortical thickness heritability at different ages in these regions.

AB - It is now well established that regional indices of brain structure such as cortical thickness, surface area or grey matter volume exhibit spatially variable patterns of heritability. However, a recent study found these patterns to change with age during development, a result supported by gene expression studies. Changes in heritability have not been investigated in adulthood so far and could have important implications in the study of heritability and genetic correlations in the brain as well as in the discovery of specific genes explaining them. Herein, we tested for genotype by age (G ×A) interactions, an extension of genotype by environment interactions, through adulthood and healthy aging in 902 subjects from the Genetics of Brain Structure (GOBS) study. A "jackknife" based method for the analysis of stable cortical thickness clusters (JASC) and scale selection is also introduced. Although additive genetic variance remained constant throughout adulthood, we found evidence for incomplete pleiotropy across age in the cortical thickness of paralimbic and parieto-temporal areas. This suggests that different genetic factors account for cortical thickness heritability at different ages in these regions.

KW - Clustering

KW - Cortical Thickness

KW - Genotype by Age Interaction

KW - Heritability

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U2 - 10.1007/s11682-014-9296-x

DO - 10.1007/s11682-014-9296-x

M3 - Article

C2 - 24752552

AN - SCOPUS:84899836578

SN - 1931-7557

VL - 8

SP - 208

EP - 216

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

IS - 2

ER -

Heritable changes in regional cortical thickness with age

Abstract

Keywords

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