High dietary intake of vegetable protein is associated with lower prevalence of renal function impairment: Results of the Dutch DIALECT-1 cohort

M.M. Oosterwijk, S.S. Soedamah-Muthu, J.M. Geleijnse, S.J.L. Bakker, G. Navis, S.H. Binnenmars, C.M. Gant, G.D. Laverman

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Introduction Dietary protein intake may influence development of renal function impairment in diabetes mellitus type 2 (T2DM). We assessed the association between sources of protein and prevalence of renal function impairment. Methods Cross-sectional analyses were performed in baseline data of 420 patients of the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1) study. Protein intake was assessed using a Food Frequency Questionnaire, modified for accurate assessment of protein intake, including types and sources of protein. Renal function impairment was defined as estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2 (Chronic Kidney Disease Epidemiology Collaboration formula). Results Among 420 patients with T2DM, 99 renal function impairment cases were identified. Multivariate Cox proportional hazard models were used and adjusted for the main lifestyle and dietary factors. The prevalence ratios in the fully adjusted model were 1 (reference), 0.74 (95% confidence interval [CI]: 0.44–1.27; P = 0.28) and 0.47 (95% CI: 0.23–0.98; P = 0.04) according to increasing tertiles of vegetable protein intake. For animal protein intake the prevalence ratios were 1 (reference), 1.10 (95% CI: 0.64–1.88; P = 0.74) and 1.06 (95% CI: 0.56–1.99; P = 0.87) according to increasing tertiles of intake. Theoretical replacement models showed that replacing 3 energy percent from animal protein by vegetable protein lowered the prevalence ratio for the association with renal function impairment to 0.20 (95% CI: 0.06–0.63; P = 0.01). Conclusion In conclusion, we found that higher intake of vegetable protein was associated with a lower prevalence of renal function impairment, and theoretical replacement of animal protein with vegetable protein was inversely associated with renal function impairment among patients with T2DM.
Original languageEnglish
Pages (from-to)710-719
JournalKidney International Reports
Volume4
Issue number5
DOIs
Publication statusPublished - 2019

Fingerprint

Vegetable Proteins
Kidney
Confidence Intervals
Glomerular Filtration Rate
Proportional Hazards Models
Type 2 Diabetes Mellitus
Theoretical Models

Keywords

  • CHRONIC KIDNEY-DISEASE
  • GLYCEMIC CONTROL
  • MANAGEMENT
  • RISK
  • SUBSTITUTION
  • diabetes mellitus type 2
  • diet
  • kidney function
  • lifestyle

Cite this

Oosterwijk, M.M. ; Soedamah-Muthu, S.S. ; Geleijnse, J.M. ; Bakker, S.J.L. ; Navis, G. ; Binnenmars, S.H. ; Gant, C.M. ; Laverman, G.D. / High dietary intake of vegetable protein is associated with lower prevalence of renal function impairment : Results of the Dutch DIALECT-1 cohort. In: Kidney International Reports. 2019 ; Vol. 4, No. 5. pp. 710-719.
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title = "High dietary intake of vegetable protein is associated with lower prevalence of renal function impairment: Results of the Dutch DIALECT-1 cohort",
abstract = "Introduction Dietary protein intake may influence development of renal function impairment in diabetes mellitus type 2 (T2DM). We assessed the association between sources of protein and prevalence of renal function impairment. Methods Cross-sectional analyses were performed in baseline data of 420 patients of the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1) study. Protein intake was assessed using a Food Frequency Questionnaire, modified for accurate assessment of protein intake, including types and sources of protein. Renal function impairment was defined as estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2 (Chronic Kidney Disease Epidemiology Collaboration formula). Results Among 420 patients with T2DM, 99 renal function impairment cases were identified. Multivariate Cox proportional hazard models were used and adjusted for the main lifestyle and dietary factors. The prevalence ratios in the fully adjusted model were 1 (reference), 0.74 (95{\%} confidence interval [CI]: 0.44–1.27; P = 0.28) and 0.47 (95{\%} CI: 0.23–0.98; P = 0.04) according to increasing tertiles of vegetable protein intake. For animal protein intake the prevalence ratios were 1 (reference), 1.10 (95{\%} CI: 0.64–1.88; P = 0.74) and 1.06 (95{\%} CI: 0.56–1.99; P = 0.87) according to increasing tertiles of intake. Theoretical replacement models showed that replacing 3 energy percent from animal protein by vegetable protein lowered the prevalence ratio for the association with renal function impairment to 0.20 (95{\%} CI: 0.06–0.63; P = 0.01). Conclusion In conclusion, we found that higher intake of vegetable protein was associated with a lower prevalence of renal function impairment, and theoretical replacement of animal protein with vegetable protein was inversely associated with renal function impairment among patients with T2DM.",
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author = "M.M. Oosterwijk and S.S. Soedamah-Muthu and J.M. Geleijnse and S.J.L. Bakker and G. Navis and S.H. Binnenmars and C.M. Gant and G.D. Laverman",
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High dietary intake of vegetable protein is associated with lower prevalence of renal function impairment : Results of the Dutch DIALECT-1 cohort. / Oosterwijk, M.M.; Soedamah-Muthu, S.S.; Geleijnse, J.M.; Bakker, S.J.L.; Navis, G.; Binnenmars, S.H.; Gant, C.M.; Laverman, G.D.

In: Kidney International Reports, Vol. 4, No. 5, 2019, p. 710-719.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - High dietary intake of vegetable protein is associated with lower prevalence of renal function impairment

T2 - Results of the Dutch DIALECT-1 cohort

AU - Oosterwijk, M.M.

AU - Soedamah-Muthu, S.S.

AU - Geleijnse, J.M.

AU - Bakker, S.J.L.

AU - Navis, G.

AU - Binnenmars, S.H.

AU - Gant, C.M.

AU - Laverman, G.D.

PY - 2019

Y1 - 2019

N2 - Introduction Dietary protein intake may influence development of renal function impairment in diabetes mellitus type 2 (T2DM). We assessed the association between sources of protein and prevalence of renal function impairment. Methods Cross-sectional analyses were performed in baseline data of 420 patients of the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1) study. Protein intake was assessed using a Food Frequency Questionnaire, modified for accurate assessment of protein intake, including types and sources of protein. Renal function impairment was defined as estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2 (Chronic Kidney Disease Epidemiology Collaboration formula). Results Among 420 patients with T2DM, 99 renal function impairment cases were identified. Multivariate Cox proportional hazard models were used and adjusted for the main lifestyle and dietary factors. The prevalence ratios in the fully adjusted model were 1 (reference), 0.74 (95% confidence interval [CI]: 0.44–1.27; P = 0.28) and 0.47 (95% CI: 0.23–0.98; P = 0.04) according to increasing tertiles of vegetable protein intake. For animal protein intake the prevalence ratios were 1 (reference), 1.10 (95% CI: 0.64–1.88; P = 0.74) and 1.06 (95% CI: 0.56–1.99; P = 0.87) according to increasing tertiles of intake. Theoretical replacement models showed that replacing 3 energy percent from animal protein by vegetable protein lowered the prevalence ratio for the association with renal function impairment to 0.20 (95% CI: 0.06–0.63; P = 0.01). Conclusion In conclusion, we found that higher intake of vegetable protein was associated with a lower prevalence of renal function impairment, and theoretical replacement of animal protein with vegetable protein was inversely associated with renal function impairment among patients with T2DM.

AB - Introduction Dietary protein intake may influence development of renal function impairment in diabetes mellitus type 2 (T2DM). We assessed the association between sources of protein and prevalence of renal function impairment. Methods Cross-sectional analyses were performed in baseline data of 420 patients of the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1) study. Protein intake was assessed using a Food Frequency Questionnaire, modified for accurate assessment of protein intake, including types and sources of protein. Renal function impairment was defined as estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2 (Chronic Kidney Disease Epidemiology Collaboration formula). Results Among 420 patients with T2DM, 99 renal function impairment cases were identified. Multivariate Cox proportional hazard models were used and adjusted for the main lifestyle and dietary factors. The prevalence ratios in the fully adjusted model were 1 (reference), 0.74 (95% confidence interval [CI]: 0.44–1.27; P = 0.28) and 0.47 (95% CI: 0.23–0.98; P = 0.04) according to increasing tertiles of vegetable protein intake. For animal protein intake the prevalence ratios were 1 (reference), 1.10 (95% CI: 0.64–1.88; P = 0.74) and 1.06 (95% CI: 0.56–1.99; P = 0.87) according to increasing tertiles of intake. Theoretical replacement models showed that replacing 3 energy percent from animal protein by vegetable protein lowered the prevalence ratio for the association with renal function impairment to 0.20 (95% CI: 0.06–0.63; P = 0.01). Conclusion In conclusion, we found that higher intake of vegetable protein was associated with a lower prevalence of renal function impairment, and theoretical replacement of animal protein with vegetable protein was inversely associated with renal function impairment among patients with T2DM.

KW - CHRONIC KIDNEY-DISEASE

KW - GLYCEMIC CONTROL

KW - MANAGEMENT

KW - RISK

KW - SUBSTITUTION

KW - diabetes mellitus type 2

KW - diet

KW - kidney function

KW - lifestyle

U2 - 10.1016/j.ekir.2019.02.009

DO - 10.1016/j.ekir.2019.02.009

M3 - Article

VL - 4

SP - 710

EP - 719

JO - Kidney International Reports

JF - Kidney International Reports

SN - 2468-0249

IS - 5

ER -