High levels of physical activity are associated with lower levels of fatigue among lymphoma patients

Results from the longitudinal PROFILES registry

O. Husson, S. Oerlemans, F. Mols, G. Schep, L.V. van de Poll-Franse

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background:
Studies show a cross-sectional association between physical activity (PA) and fatigue among lymphoma cancer patients. However, few longitudinal studies have examined whether PA has a sustained effect on fatigue over time.
Purpose:To examine the longitudinal relationship between PA and fatigue.
Methods:
All living individuals diagnosed with lymphoma between 1999 and 2010 as registered by the Dutch population-based Eindhoven Cancer Registry received a questionnaire on three time points. Generalized linear mixed models were used to estimate the independent effects of PA on fatigue.RESULTS:PA and fatigue levels did not differ between patients short-term (< 1 year) and long-term after diagnosis (1-5 years or > 5 years). PA behavior was relatively constant over time with 84% of the patients meeting the Dutch PA guidelines at all assessment periods. Fatigue scores also remained fairly stable over time with 46% of the patients never being fatigued and 29% always being fatigued. Multivariate analyses showed that patients who met the PA guidelines scored 6.2 (95% CI 3.1-9.2) points lower on total fatigue over time (between subject effect; p < 0.01), compared to patients not meeting PA guidelines.
Conclusion:
During a period of two years, PA and fatigue levels were rather stable within lymphoma patients. Patients who met the PA guidelines reported lower levels of fatigue compared to those not meeting the guidelines, which appeared to be a constant association over time. The observed association between PA and fatigue underlines the importance to focus upon physical training in the care of cancer patients.
Original languageEnglish
Pages (from-to)678-684
JournalActa Oncologica
Volume54
Issue number5
DOIs
Publication statusPublished - 2015

Fingerprint

Lymphoma
Exercise
Neoplasms
Linear Models
Multivariate Analysis

Cite this

@article{08ba4cfbbd484498aa7ad969e388ed37,
title = "High levels of physical activity are associated with lower levels of fatigue among lymphoma patients: Results from the longitudinal PROFILES registry",
abstract = "Background:Studies show a cross-sectional association between physical activity (PA) and fatigue among lymphoma cancer patients. However, few longitudinal studies have examined whether PA has a sustained effect on fatigue over time.Purpose:To examine the longitudinal relationship between PA and fatigue.Methods:All living individuals diagnosed with lymphoma between 1999 and 2010 as registered by the Dutch population-based Eindhoven Cancer Registry received a questionnaire on three time points. Generalized linear mixed models were used to estimate the independent effects of PA on fatigue.RESULTS:PA and fatigue levels did not differ between patients short-term (< 1 year) and long-term after diagnosis (1-5 years or > 5 years). PA behavior was relatively constant over time with 84{\%} of the patients meeting the Dutch PA guidelines at all assessment periods. Fatigue scores also remained fairly stable over time with 46{\%} of the patients never being fatigued and 29{\%} always being fatigued. Multivariate analyses showed that patients who met the PA guidelines scored 6.2 (95{\%} CI 3.1-9.2) points lower on total fatigue over time (between subject effect; p < 0.01), compared to patients not meeting PA guidelines.Conclusion:During a period of two years, PA and fatigue levels were rather stable within lymphoma patients. Patients who met the PA guidelines reported lower levels of fatigue compared to those not meeting the guidelines, which appeared to be a constant association over time. The observed association between PA and fatigue underlines the importance to focus upon physical training in the care of cancer patients.",
author = "O. Husson and S. Oerlemans and F. Mols and G. Schep and {van de Poll-Franse}, L.V.",
year = "2015",
doi = "10.3109/0284186X.2014.996664",
language = "English",
volume = "54",
pages = "678--684",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "TAYLOR & FRANCIS LTD",
number = "5",

}

High levels of physical activity are associated with lower levels of fatigue among lymphoma patients : Results from the longitudinal PROFILES registry. / Husson, O.; Oerlemans, S.; Mols, F.; Schep, G.; van de Poll-Franse, L.V.

In: Acta Oncologica, Vol. 54, No. 5, 2015, p. 678-684.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - High levels of physical activity are associated with lower levels of fatigue among lymphoma patients

T2 - Results from the longitudinal PROFILES registry

AU - Husson, O.

AU - Oerlemans, S.

AU - Mols, F.

AU - Schep, G.

AU - van de Poll-Franse, L.V.

PY - 2015

Y1 - 2015

N2 - Background:Studies show a cross-sectional association between physical activity (PA) and fatigue among lymphoma cancer patients. However, few longitudinal studies have examined whether PA has a sustained effect on fatigue over time.Purpose:To examine the longitudinal relationship between PA and fatigue.Methods:All living individuals diagnosed with lymphoma between 1999 and 2010 as registered by the Dutch population-based Eindhoven Cancer Registry received a questionnaire on three time points. Generalized linear mixed models were used to estimate the independent effects of PA on fatigue.RESULTS:PA and fatigue levels did not differ between patients short-term (< 1 year) and long-term after diagnosis (1-5 years or > 5 years). PA behavior was relatively constant over time with 84% of the patients meeting the Dutch PA guidelines at all assessment periods. Fatigue scores also remained fairly stable over time with 46% of the patients never being fatigued and 29% always being fatigued. Multivariate analyses showed that patients who met the PA guidelines scored 6.2 (95% CI 3.1-9.2) points lower on total fatigue over time (between subject effect; p < 0.01), compared to patients not meeting PA guidelines.Conclusion:During a period of two years, PA and fatigue levels were rather stable within lymphoma patients. Patients who met the PA guidelines reported lower levels of fatigue compared to those not meeting the guidelines, which appeared to be a constant association over time. The observed association between PA and fatigue underlines the importance to focus upon physical training in the care of cancer patients.

AB - Background:Studies show a cross-sectional association between physical activity (PA) and fatigue among lymphoma cancer patients. However, few longitudinal studies have examined whether PA has a sustained effect on fatigue over time.Purpose:To examine the longitudinal relationship between PA and fatigue.Methods:All living individuals diagnosed with lymphoma between 1999 and 2010 as registered by the Dutch population-based Eindhoven Cancer Registry received a questionnaire on three time points. Generalized linear mixed models were used to estimate the independent effects of PA on fatigue.RESULTS:PA and fatigue levels did not differ between patients short-term (< 1 year) and long-term after diagnosis (1-5 years or > 5 years). PA behavior was relatively constant over time with 84% of the patients meeting the Dutch PA guidelines at all assessment periods. Fatigue scores also remained fairly stable over time with 46% of the patients never being fatigued and 29% always being fatigued. Multivariate analyses showed that patients who met the PA guidelines scored 6.2 (95% CI 3.1-9.2) points lower on total fatigue over time (between subject effect; p < 0.01), compared to patients not meeting PA guidelines.Conclusion:During a period of two years, PA and fatigue levels were rather stable within lymphoma patients. Patients who met the PA guidelines reported lower levels of fatigue compared to those not meeting the guidelines, which appeared to be a constant association over time. The observed association between PA and fatigue underlines the importance to focus upon physical training in the care of cancer patients.

UR - http://hdl.handle.net/10411/20591

U2 - 10.3109/0284186X.2014.996664

DO - 10.3109/0284186X.2014.996664

M3 - Article

VL - 54

SP - 678

EP - 684

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 5

ER -