Hubs in the human fetal brain network

M.I. van den Heuvel, E. Turk, J.H. Manning, J. Hect, E. Hernandez-Andrade⁠, S.S. Hassan, R. Romero, M.P. van den Heuvel, Moriah E. Thomason

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Abstract

Advances in neuroimaging and network analyses have lead to discovery of highly connected regions, or hubs, in the connectional architecture of the human brain. Whether these hubs emerge as networks begin to form in utero, has yet to be examined. The current study addresses this question and aims to determine the location of neural hubs in human fetuses. Fetal resting-state fMRI data (N=105) was used to construct connectivity matrices for 197 discrete brain regions. We discovered that within the connectional functional organization of the human fetal brain key hubs are emerging. Consistent with prior reports in infants, visual and motor regions were identified as emerging hub areas, specifically in cerebellar areas. We also found evidence for network hubs in association cortex, including areas remarkably close to the adult fusiform facial and Wernicke areas. Functional significance of hub structure was confirmed by computationally deleting hub versus random nodes and observing that global efficiency decreased significantly more when hubs were removed (p<.001). Taken together, we conclude that both primary and association brain regions demonstrate centrality in network organization before birth. While fetal hubs may be important for facilitating network communication, they may also form potential points of vulnerability in fetal brain development.
Original languageEnglish
Pages (from-to)108-115
JournalDevelopmental Cognitive Neuroscience
Volume30
DOIs
Publication statusPublished - 2018

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Neuroimaging
Fetus
Communication

Keywords

  • ARCHITECTURE
  • ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
  • Brain networks
  • Development
  • FUNCTIONAL CONNECTIVITY
  • Fetus
  • Functional connectivity
  • HUMAN CONNECTOME
  • Hubs
  • IN-UTERO
  • INFANT BRAIN
  • PREMATURE-INFANT
  • Prenatal
  • RESTING-STATE FMRI
  • RICH-CLUB ORGANIZATION
  • WHITE-MATTER

Cite this

van den Heuvel, M. I., Turk, E., Manning, J. H., Hect, J., Hernandez-Andrade⁠, E., Hassan, S. S., ... Thomason, M. E. (2018). Hubs in the human fetal brain network. Developmental Cognitive Neuroscience, 30, 108-115. https://doi.org/10.1016/j.dcn.2018.02.001
van den Heuvel, M.I. ; Turk, E. ; Manning, J.H. ; Hect, J. ; Hernandez-Andrade⁠, E. ; Hassan, S.S. ; Romero, R. ; van den Heuvel, M.P. ; Thomason, Moriah E. / Hubs in the human fetal brain network. In: Developmental Cognitive Neuroscience. 2018 ; Vol. 30. pp. 108-115.
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van den Heuvel, MI, Turk, E, Manning, JH, Hect, J, Hernandez-Andrade⁠, E, Hassan, SS, Romero, R, van den Heuvel, MP & Thomason, ME 2018, 'Hubs in the human fetal brain network' Developmental Cognitive Neuroscience, vol. 30, pp. 108-115. https://doi.org/10.1016/j.dcn.2018.02.001

Hubs in the human fetal brain network. / van den Heuvel, M.I.; Turk, E.; Manning, J.H.; Hect, J.; Hernandez-Andrade⁠, E.; Hassan, S.S.; Romero, R.; van den Heuvel, M.P.; Thomason, Moriah E.

In: Developmental Cognitive Neuroscience, Vol. 30, 2018, p. 108-115.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Hubs in the human fetal brain network

AU - van den Heuvel, M.I.

AU - Turk, E.

AU - Manning, J.H.

AU - Hect, J.

AU - Hernandez-Andrade⁠, E.

AU - Hassan, S.S.

AU - Romero, R.

AU - van den Heuvel, M.P.

AU - Thomason, Moriah E.

PY - 2018

Y1 - 2018

N2 - Advances in neuroimaging and network analyses have lead to discovery of highly connected regions, or hubs, in the connectional architecture of the human brain. Whether these hubs emerge as networks begin to form in utero, has yet to be examined. The current study addresses this question and aims to determine the location of neural hubs in human fetuses. Fetal resting-state fMRI data (N=105) was used to construct connectivity matrices for 197 discrete brain regions. We discovered that within the connectional functional organization of the human fetal brain key hubs are emerging. Consistent with prior reports in infants, visual and motor regions were identified as emerging hub areas, specifically in cerebellar areas. We also found evidence for network hubs in association cortex, including areas remarkably close to the adult fusiform facial and Wernicke areas. Functional significance of hub structure was confirmed by computationally deleting hub versus random nodes and observing that global efficiency decreased significantly more when hubs were removed (p<.001). Taken together, we conclude that both primary and association brain regions demonstrate centrality in network organization before birth. While fetal hubs may be important for facilitating network communication, they may also form potential points of vulnerability in fetal brain development.

AB - Advances in neuroimaging and network analyses have lead to discovery of highly connected regions, or hubs, in the connectional architecture of the human brain. Whether these hubs emerge as networks begin to form in utero, has yet to be examined. The current study addresses this question and aims to determine the location of neural hubs in human fetuses. Fetal resting-state fMRI data (N=105) was used to construct connectivity matrices for 197 discrete brain regions. We discovered that within the connectional functional organization of the human fetal brain key hubs are emerging. Consistent with prior reports in infants, visual and motor regions were identified as emerging hub areas, specifically in cerebellar areas. We also found evidence for network hubs in association cortex, including areas remarkably close to the adult fusiform facial and Wernicke areas. Functional significance of hub structure was confirmed by computationally deleting hub versus random nodes and observing that global efficiency decreased significantly more when hubs were removed (p<.001). Taken together, we conclude that both primary and association brain regions demonstrate centrality in network organization before birth. While fetal hubs may be important for facilitating network communication, they may also form potential points of vulnerability in fetal brain development.

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KW - Functional connectivity

KW - HUMAN CONNECTOME

KW - Hubs

KW - IN-UTERO

KW - INFANT BRAIN

KW - PREMATURE-INFANT

KW - Prenatal

KW - RESTING-STATE FMRI

KW - RICH-CLUB ORGANIZATION

KW - WHITE-MATTER

U2 - 10.1016/j.dcn.2018.02.001

DO - 10.1016/j.dcn.2018.02.001

M3 - Article

VL - 30

SP - 108

EP - 115

JO - Developmental Cognitive Neuroscience

JF - Developmental Cognitive Neuroscience

SN - 1878-9293

ER -

van den Heuvel MI, Turk E, Manning JH, Hect J, Hernandez-Andrade⁠ E, Hassan SS et al. Hubs in the human fetal brain network. Developmental Cognitive Neuroscience. 2018;30:108-115. https://doi.org/10.1016/j.dcn.2018.02.001