Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: Results ofa pilot study

Sanne J H van Erp, Laura W Leicher, Simone D Hennink, Zeinab Ghorbanoghli, Simone A C Breg, Hans Morreau, Maartje Nielsen, James C H Hardwick, J.A. Roukema, Alexandra M J Langers, Hans F A Vasen, Wouter H de Vos Tot Nederveen Cappel

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Abstract

Objectives: 

In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance.

Material and methods: 

This retrospective observational study was performed in two large hospitals. Individuals aged between 55 and 75 years with a positive I-FOBT that underwent colonoscopy were included. A detailed family history was obtained in all individuals.

Results: 

A total of 657 individuals with a positive I-FOBT test underwent colonoscopy. A total of 120 (18.3%) participants were found to have a positive family history for CRC, 20 (3.0%) fulfilled the FCC criteria, 4 (0.6%) the Bethesda guidelines and 1 (0.2%) participant the Amsterdam criteria. Multiple adenomas (>10) were found in 21 (3.2%) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3%) required referral to the clinical geneticist and the relatives of 20 (3.0%) participants should be referred for surveillance colonoscopy.

Conclusion: 

Obtaining a detailed family history at the time of intake of participants with a positive I-FOBT in the Dutch surveillance program increased the identification of participants with familial CRC.

Original languageEnglish
Pages (from-to)1227-1232
JournalScandinavian Journal of Gastroenterology
Volume51
Issue number10
DOIs
Publication statusPublished - 2016

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