Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: Results ofa pilot study

Sanne J H van Erp; Laura W Leicher; Simone D Hennink; Zeinab Ghorbanoghli; Simone A C Breg; Hans Morreau; Maartje Nielsen; James C H Hardwick; J.A. Roukema; Alexandra M J Langers; Hans F A Vasen; Wouter H de Vos Tot Nederveen Cappel

doi:10.1080/00365521.2016.1193219

Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: Results ofa pilot study

Sanne J H van Erp, Laura W Leicher, Simone D Hennink, Zeinab Ghorbanoghli, Simone A C Breg, Hans Morreau, Maartje Nielsen, James C H Hardwick, J.A. Roukema, Alexandra M J Langers, Hans F A Vasen, Wouter H de Vos Tot Nederveen Cappel

Medical and Clinical Psychology

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

Objectives:

In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance.

Material and methods:

This retrospective observational study was performed in two large hospitals. Individuals aged between 55 and 75 years with a positive I-FOBT that underwent colonoscopy were included. A detailed family history was obtained in all individuals.

Results:

A total of 657 individuals with a positive I-FOBT test underwent colonoscopy. A total of 120 (18.3%) participants were found to have a positive family history for CRC, 20 (3.0%) fulfilled the FCC criteria, 4 (0.6%) the Bethesda guidelines and 1 (0.2%) participant the Amsterdam criteria. Multiple adenomas (>10) were found in 21 (3.2%) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3%) required referral to the clinical geneticist and the relatives of 20 (3.0%) participants should be referred for surveillance colonoscopy.

Conclusion:

Obtaining a detailed family history at the time of intake of participants with a positive I-FOBT in the Dutch surveillance program increased the identification of participants with familial CRC.

Original language	English
Pages (from-to)	1227-1232
Journal	Scandinavian Journal of Gastroenterology
Volume	51
Issue number	10
DOIs	https://doi.org/10.1080/00365521.2016.1193219
Publication status	Published - 2016

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10.1080/00365521.2016.1193219

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van Erp, S. J. H., Leicher, L. W., Hennink, S. D., Ghorbanoghli, Z., Breg, S. A. C., Morreau, H., Nielsen, M., Hardwick, J. C. H., Roukema, J. A., Langers, A. M. J., Vasen, H. F. A., & Cappel, W. H. D. V. T. N. (2016). Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: Results ofa pilot study. Scandinavian Journal of Gastroenterology, 51(10), 1227-1232. https://doi.org/10.1080/00365521.2016.1193219

van Erp, Sanne J H ; Leicher, Laura W ; Hennink, Simone D ; Ghorbanoghli, Zeinab ; Breg, Simone A C ; Morreau, Hans ; Nielsen, Maartje ; Hardwick, James C H ; Roukema, J.A. ; Langers, Alexandra M J ; Vasen, Hans F A ; Cappel, Wouter H de Vos Tot Nederveen. / Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program : Results ofa pilot study. In: Scandinavian Journal of Gastroenterology. 2016 ; Vol. 51, No. 10. pp. 1227-1232.

@article{88fc78d0c1c1472384294db2a35ee270,

title = "Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: Results ofa pilot study",

abstract = "Objectives: In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance.Material and methods: This retrospective observational study was performed in two large hospitals. Individuals aged between 55 and 75 years with a positive I-FOBT that underwent colonoscopy were included. A detailed family history was obtained in all individuals.Results: A total of 657 individuals with a positive I-FOBT test underwent colonoscopy. A total of 120 (18.3%) participants were found to have a positive family history for CRC, 20 (3.0%) fulfilled the FCC criteria, 4 (0.6%) the Bethesda guidelines and 1 (0.2%) participant the Amsterdam criteria. Multiple adenomas (>10) were found in 21 (3.2%) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3%) required referral to the clinical geneticist and the relatives of 20 (3.0%) participants should be referred for surveillance colonoscopy.Conclusion: Obtaining a detailed family history at the time of intake of participants with a positive I-FOBT in the Dutch surveillance program increased the identification of participants with familial CRC.",

author = "{van Erp}, {Sanne J H} and Leicher, {Laura W} and Hennink, {Simone D} and Zeinab Ghorbanoghli and Breg, {Simone A C} and Hans Morreau and Maartje Nielsen and Hardwick, {James C H} and J.A. Roukema and Langers, {Alexandra M J} and Vasen, {Hans F A} and Cappel, {Wouter H de Vos Tot Nederveen}",

note = "Geen affiliatie met TiU. Affilatie EZ",

year = "2016",

doi = "10.1080/00365521.2016.1193219",

language = "English",

volume = "51",

pages = "1227--1232",

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van Erp, SJH, Leicher, LW, Hennink, SD, Ghorbanoghli, Z, Breg, SAC, Morreau, H, Nielsen, M, Hardwick, JCH, Roukema, JA, Langers, AMJ, Vasen, HFA & Cappel, WHDVTN 2016, 'Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: Results ofa pilot study', Scandinavian Journal of Gastroenterology, vol. 51, no. 10, pp. 1227-1232. https://doi.org/10.1080/00365521.2016.1193219

Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program : Results ofa pilot study. / van Erp, Sanne J H; Leicher, Laura W; Hennink, Simone D; Ghorbanoghli, Zeinab; Breg, Simone A C; Morreau, Hans; Nielsen, Maartje; Hardwick, James C H; Roukema, J.A.; Langers, Alexandra M J; Vasen, Hans F A; Cappel, Wouter H de Vos Tot Nederveen.

In: Scandinavian Journal of Gastroenterology, Vol. 51, No. 10, 2016, p. 1227-1232.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program

T2 - Results ofa pilot study

AU - van Erp, Sanne J H

AU - Leicher, Laura W

AU - Hennink, Simone D

AU - Ghorbanoghli, Zeinab

AU - Breg, Simone A C

AU - Morreau, Hans

AU - Nielsen, Maartje

AU - Hardwick, James C H

AU - Roukema, J.A.

AU - Langers, Alexandra M J

AU - Vasen, Hans F A

AU - Cappel, Wouter H de Vos Tot Nederveen

N1 - Geen affiliatie met TiU. Affilatie EZ

PY - 2016

Y1 - 2016

N2 - Objectives: In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance.Material and methods: This retrospective observational study was performed in two large hospitals. Individuals aged between 55 and 75 years with a positive I-FOBT that underwent colonoscopy were included. A detailed family history was obtained in all individuals.Results: A total of 657 individuals with a positive I-FOBT test underwent colonoscopy. A total of 120 (18.3%) participants were found to have a positive family history for CRC, 20 (3.0%) fulfilled the FCC criteria, 4 (0.6%) the Bethesda guidelines and 1 (0.2%) participant the Amsterdam criteria. Multiple adenomas (>10) were found in 21 (3.2%) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3%) required referral to the clinical geneticist and the relatives of 20 (3.0%) participants should be referred for surveillance colonoscopy.Conclusion: Obtaining a detailed family history at the time of intake of participants with a positive I-FOBT in the Dutch surveillance program increased the identification of participants with familial CRC.

AB - Objectives: In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance.Material and methods: This retrospective observational study was performed in two large hospitals. Individuals aged between 55 and 75 years with a positive I-FOBT that underwent colonoscopy were included. A detailed family history was obtained in all individuals.Results: A total of 657 individuals with a positive I-FOBT test underwent colonoscopy. A total of 120 (18.3%) participants were found to have a positive family history for CRC, 20 (3.0%) fulfilled the FCC criteria, 4 (0.6%) the Bethesda guidelines and 1 (0.2%) participant the Amsterdam criteria. Multiple adenomas (>10) were found in 21 (3.2%) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3%) required referral to the clinical geneticist and the relatives of 20 (3.0%) participants should be referred for surveillance colonoscopy.Conclusion: Obtaining a detailed family history at the time of intake of participants with a positive I-FOBT in the Dutch surveillance program increased the identification of participants with familial CRC.

U2 - 10.1080/00365521.2016.1193219

DO - 10.1080/00365521.2016.1193219

M3 - Article

C2 - 27310819

VL - 51

SP - 1227

EP - 1232

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 10

ER -

Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: Results ofa pilot study

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