Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: Results ofa pilot study

Sanne J H van Erp, Laura W Leicher, Simone D Hennink, Zeinab Ghorbanoghli, Simone A C Breg, Hans Morreau, Maartje Nielsen, James C H Hardwick, J.A. Roukema, Alexandra M J Langers, Hans F A Vasen, Wouter H de Vos Tot Nederveen Cappel

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Objectives: 

In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance.

Material and methods: 

This retrospective observational study was performed in two large hospitals. Individuals aged between 55 and 75 years with a positive I-FOBT that underwent colonoscopy were included. A detailed family history was obtained in all individuals.

Results: 

A total of 657 individuals with a positive I-FOBT test underwent colonoscopy. A total of 120 (18.3%) participants were found to have a positive family history for CRC, 20 (3.0%) fulfilled the FCC criteria, 4 (0.6%) the Bethesda guidelines and 1 (0.2%) participant the Amsterdam criteria. Multiple adenomas (>10) were found in 21 (3.2%) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3%) required referral to the clinical geneticist and the relatives of 20 (3.0%) participants should be referred for surveillance colonoscopy.

Conclusion: 

Obtaining a detailed family history at the time of intake of participants with a positive I-FOBT in the Dutch surveillance program increased the identification of participants with familial CRC.

Original languageEnglish
Pages (from-to)1227-1232
JournalScandinavian Journal of Gastroenterology
Volume51
Issue number10
DOIs
Publication statusPublished - 2016

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Occult Blood
Genetic Counseling
Adenoma
Netherlands

Cite this

van Erp, Sanne J H ; Leicher, Laura W ; Hennink, Simone D ; Ghorbanoghli, Zeinab ; Breg, Simone A C ; Morreau, Hans ; Nielsen, Maartje ; Hardwick, James C H ; Roukema, J.A. ; Langers, Alexandra M J ; Vasen, Hans F A ; Cappel, Wouter H de Vos Tot Nederveen. / Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program : Results ofa pilot study. In: Scandinavian Journal of Gastroenterology. 2016 ; Vol. 51, No. 10. pp. 1227-1232.
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title = "Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: Results ofa pilot study",
abstract = "Objectives: In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance.Material and methods: This retrospective observational study was performed in two large hospitals. Individuals aged between 55 and 75 years with a positive I-FOBT that underwent colonoscopy were included. A detailed family history was obtained in all individuals.Results: A total of 657 individuals with a positive I-FOBT test underwent colonoscopy. A total of 120 (18.3{\%}) participants were found to have a positive family history for CRC, 20 (3.0{\%}) fulfilled the FCC criteria, 4 (0.6{\%}) the Bethesda guidelines and 1 (0.2{\%}) participant the Amsterdam criteria. Multiple adenomas (>10) were found in 21 (3.2{\%}) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3{\%}) required referral to the clinical geneticist and the relatives of 20 (3.0{\%}) participants should be referred for surveillance colonoscopy.Conclusion: Obtaining a detailed family history at the time of intake of participants with a positive I-FOBT in the Dutch surveillance program increased the identification of participants with familial CRC.",
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van Erp, SJH, Leicher, LW, Hennink, SD, Ghorbanoghli, Z, Breg, SAC, Morreau, H, Nielsen, M, Hardwick, JCH, Roukema, JA, Langers, AMJ, Vasen, HFA & Cappel, WHDVTN 2016, 'Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: Results ofa pilot study', Scandinavian Journal of Gastroenterology, vol. 51, no. 10, pp. 1227-1232. https://doi.org/10.1080/00365521.2016.1193219

Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program : Results ofa pilot study. / van Erp, Sanne J H; Leicher, Laura W; Hennink, Simone D; Ghorbanoghli, Zeinab; Breg, Simone A C; Morreau, Hans; Nielsen, Maartje; Hardwick, James C H; Roukema, J.A.; Langers, Alexandra M J; Vasen, Hans F A; Cappel, Wouter H de Vos Tot Nederveen.

In: Scandinavian Journal of Gastroenterology, Vol. 51, No. 10, 2016, p. 1227-1232.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program

T2 - Results ofa pilot study

AU - van Erp, Sanne J H

AU - Leicher, Laura W

AU - Hennink, Simone D

AU - Ghorbanoghli, Zeinab

AU - Breg, Simone A C

AU - Morreau, Hans

AU - Nielsen, Maartje

AU - Hardwick, James C H

AU - Roukema, J.A.

AU - Langers, Alexandra M J

AU - Vasen, Hans F A

AU - Cappel, Wouter H de Vos Tot Nederveen

N1 - Geen affiliatie met TiU. Affilatie EZ

PY - 2016

Y1 - 2016

N2 - Objectives: In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance.Material and methods: This retrospective observational study was performed in two large hospitals. Individuals aged between 55 and 75 years with a positive I-FOBT that underwent colonoscopy were included. A detailed family history was obtained in all individuals.Results: A total of 657 individuals with a positive I-FOBT test underwent colonoscopy. A total of 120 (18.3%) participants were found to have a positive family history for CRC, 20 (3.0%) fulfilled the FCC criteria, 4 (0.6%) the Bethesda guidelines and 1 (0.2%) participant the Amsterdam criteria. Multiple adenomas (>10) were found in 21 (3.2%) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3%) required referral to the clinical geneticist and the relatives of 20 (3.0%) participants should be referred for surveillance colonoscopy.Conclusion: Obtaining a detailed family history at the time of intake of participants with a positive I-FOBT in the Dutch surveillance program increased the identification of participants with familial CRC.

AB - Objectives: In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance.Material and methods: This retrospective observational study was performed in two large hospitals. Individuals aged between 55 and 75 years with a positive I-FOBT that underwent colonoscopy were included. A detailed family history was obtained in all individuals.Results: A total of 657 individuals with a positive I-FOBT test underwent colonoscopy. A total of 120 (18.3%) participants were found to have a positive family history for CRC, 20 (3.0%) fulfilled the FCC criteria, 4 (0.6%) the Bethesda guidelines and 1 (0.2%) participant the Amsterdam criteria. Multiple adenomas (>10) were found in 21 (3.2%) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3%) required referral to the clinical geneticist and the relatives of 20 (3.0%) participants should be referred for surveillance colonoscopy.Conclusion: Obtaining a detailed family history at the time of intake of participants with a positive I-FOBT in the Dutch surveillance program increased the identification of participants with familial CRC.

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DO - 10.1080/00365521.2016.1193219

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