Identifying the subtypes of cancer-related fatigue: Results from the population-based PROFILES registry

M.S.Y. Thong, F. Mols, L.V. van de Poll-Franse, M.A.G. Sprangers, C.C.D. van der Rijt, A.M. Barsevick, H. Knoop, O. Husson

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Abstract

Purpose
Little research has been done to identify possible cancer-related fatigue (CRF) subtypes and to classify cancer survivors accordingly. We aimed to identify CRF subtypes in a large population-based sample of (long term) stage I–III colorectal cancer survivors. We also identified factors associated with the CRF subtypes.
Methods
Respondents completed the Multidimensional Fatigue Inventory and other validated questionnaires on anxiety and reduced positive affect (anhedonia), sleep quality, and lifestyle factors (body mass index and physical activity). Latent class analysis was used to derive the CRF subtypes. Factors associated with the derived CRF subtypes were determined with multinomial logistic regression.
Results
Three CRF classes were identified: class 1 (no fatigue and distress, n = 644, 56%), class 2 (low fatigue, moderate distress, n = 256, 22%), and class 3 (high fatigue, moderate distress, n = 256, 22%). Multinomial logistic regression results show that survivors in class 3 were more likely to be female, were treated with radiotherapy, have comorbid diabetes mellitus, and be overweight/obese than survivors in class 1 (reference). Survivors in classes 2 and 3 were also more likely to have comorbid heart condition, report poorer sleep quality, experience anhedonia, and report more anxiety symptoms when compared with survivors in class 1.
Conclusions
Three distinct classes of CRF were identified which could be differentiated with sleep quality, anxiety, anhedonia, and lifestyle factors.
Implications for cancer survivors
The identification of CRF subtypes with distinct characteristics suggests that interventions should be targeted to the CRF subtype.
Keywords: Cancer, Latent class analysis, Fatigue subtypes, Population-based Survivors
Original languageEnglish
Pages (from-to)38-46
JournalJournal of Cancer Survivorship
Volume12
Issue number1
DOIs
Publication statusPublished - 2018

Keywords

  • BEHAVIOR
  • CLINICAL-TRIALS
  • Cancer
  • EVENING FATIGUE
  • Fatigue subtypes
  • INSTRUMENT
  • Latent class analysis
  • PHYSICAL-ACTIVITIES
  • POSITIVE AFFECT ANHEDONIA
  • Population-based
  • QUALITY-OF-LIFE
  • QUESTIONNAIRE
  • RANDOMIZED CONTROLLED-TRIAL
  • SURVIVORS
  • Survivors

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