Impaired health status, psychological distress, and personality in women and men with nonobstructive coronary artery disease: Sex and gender differences: The TWIST (Tweesteden Mild Stenosis Study)

P.M.C. Mommersteeg, Lindy Arts, W.P. Zijlstra, J.W.C.M. Widdershoven, W. Aarnoudse, J. Denollet

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)
78 Downloads (Pure)

Abstract

Background
Patients with nonobstructive coronary artery disease (NOCAD; wall irregularities, stenosis <60%), and women with NOCAD in particular, remain underinvestigated. We examined sex and gender (S&G) differences in health status, psychological distress, and personality between patients with NOCAD and the general population, as well as S&G differences within the NOCAD population.Methods and 
Results
In total, 523 patients with NOCAD (61±9 years, 52% women) were included via coronary angiography and computed tomography as part of the TWIST (Tweesteden Mild Stenosis) study. Generic health status (12-item Short Form physical and mental scales and fatigue), psychological distress (Hospital Anxiety and Depression Scale anxiety and depressive symptoms and Global Mood Scale negative and positive affect), and personality (Type D personality) were compared between patients with NOCAD and an age- and sex-matched group of 1347 people from the general population. Frequency matching was performed to obtain a similar sex distribution in each age–decile group. Both men and women with NOCAD reported impaired health status, more psychological distress, and Type D personality compared with men and women in the reference group. Women reported more psychosocial distress compared with men, but no significant sex-by-group interaction effects were observed. Women with NOCAD reported impaired health status, more anxiety, and less positive affect, but no differences in depressive symptoms, angina, or Type D personality when compared with men with NOCAD. Age, education, employment, partner, and alcohol use explained these S&G differences within the NOCAD group. 
Conclusions
In both men and women, NOCAD was associated with impaired health status, more psychological distress, and Type D personality when compared with a reference population. Factors reflecting S&G differences explained these S&G findings in patient-reported outcomes.
Original languageEnglish
Article numbere003597
JournalCirculation. Cardiovascular Quality and Outcomes
Volume10
Issue number2
DOIs
Publication statusPublished - 2017

Fingerprint Dive into the research topics of 'Impaired health status, psychological distress, and personality in women and men with nonobstructive coronary artery disease: Sex and gender differences: The TWIST (Tweesteden Mild Stenosis Study)'. Together they form a unique fingerprint.

  • Cite this