Intake of marine-derived omega-3 polyunsaturated fatty acids and mortality in renal transplant recipients

António Gomes Neto, Camilo Sotomayor, Ilse Pranger, Else Van Den Berg, Rijk Gans, S.S. Soedamah-Muthu, Gerjan Navis, Stephan Bakker

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Abstract

The effect of marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFA) on long-term outcome in renal transplant recipients (RTR) remains unclear. We investigated whether marine-derived n-3 PUFA intake is associated with all-cause and cardiovascular (CV) mortality in RTR. Intake of eicosapentaenoic acid plus docosahexaenoic acid (EPA-DHA) was assessed using a validated Food Frequency Questionnaire. Cox regression analyses were performed to evaluate the associations of EPA-DHA intake with all-cause and CV mortality. We included 627 RTR (age 53 13 years). EPA-DHA intake was 102 (42–215) mg/day. During median follow-up of 5.4 years, 130 (21%) RTR died, with 52 (8.3%) due to CV causes. EPA-DHA intake was associated with lower risk of all-cause mortality (Hazard Ratio (HR) 0.85; 95% confidence interval (95% CI) 0.75–0.97). Age (p = 0.03) and smoking status (p = 0.01) significantly modified this association, with lower risk of all-cause and CV mortality particularly in older (HR 0.75, 95% CI 0.61–0.92; HR 0.68, 95% CI 0.48–0.95) and non-smoking RTR (HR 0.80, 95% CI 0.68–0.93; HR 0.74, 95% CI 0.56–0.98). In conclusion, marine-derived n-3 PUFA intake is inversely associated with risk of all-cause and CV mortality in RTR. The strongest associations were present in subgroups of patients, which adds further evidence to the plea for EPA-DHA supplementation, particularly in elderly and non-smoking RTR
Original languageEnglish
Article number363
JournalNutrients
Volume9
Issue number4
DOIs
Publication statusPublished - 2017

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Unsaturated Fatty Acids
Eicosapentaenoic Acid
Kidney
Confidence Intervals

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Gomes Neto, António ; Sotomayor, Camilo ; Pranger, Ilse ; Van Den Berg, Else ; Gans, Rijk ; Soedamah-Muthu, S.S. ; Navis, Gerjan ; Bakker, Stephan. / Intake of marine-derived omega-3 polyunsaturated fatty acids and mortality in renal transplant recipients. In: Nutrients. 2017 ; Vol. 9, No. 4.
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title = "Intake of marine-derived omega-3 polyunsaturated fatty acids and mortality in renal transplant recipients",
abstract = "The effect of marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFA) on long-term outcome in renal transplant recipients (RTR) remains unclear. We investigated whether marine-derived n-3 PUFA intake is associated with all-cause and cardiovascular (CV) mortality in RTR. Intake of eicosapentaenoic acid plus docosahexaenoic acid (EPA-DHA) was assessed using a validated Food Frequency Questionnaire. Cox regression analyses were performed to evaluate the associations of EPA-DHA intake with all-cause and CV mortality. We included 627 RTR (age 53 13 years). EPA-DHA intake was 102 (42–215) mg/day. During median follow-up of 5.4 years, 130 (21{\%}) RTR died, with 52 (8.3{\%}) due to CV causes. EPA-DHA intake was associated with lower risk of all-cause mortality (Hazard Ratio (HR) 0.85; 95{\%} confidence interval (95{\%} CI) 0.75–0.97). Age (p = 0.03) and smoking status (p = 0.01) significantly modified this association, with lower risk of all-cause and CV mortality particularly in older (HR 0.75, 95{\%} CI 0.61–0.92; HR 0.68, 95{\%} CI 0.48–0.95) and non-smoking RTR (HR 0.80, 95{\%} CI 0.68–0.93; HR 0.74, 95{\%} CI 0.56–0.98). In conclusion, marine-derived n-3 PUFA intake is inversely associated with risk of all-cause and CV mortality in RTR. The strongest associations were present in subgroups of patients, which adds further evidence to the plea for EPA-DHA supplementation, particularly in elderly and non-smoking RTR",
author = "{Gomes Neto}, Ant{\'o}nio and Camilo Sotomayor and Ilse Pranger and {Van Den Berg}, Else and Rijk Gans and S.S. Soedamah-Muthu and Gerjan Navis and Stephan Bakker",
year = "2017",
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Gomes Neto, A, Sotomayor, C, Pranger, I, Van Den Berg, E, Gans, R, Soedamah-Muthu, SS, Navis, G & Bakker, S 2017, 'Intake of marine-derived omega-3 polyunsaturated fatty acids and mortality in renal transplant recipients', Nutrients, vol. 9, no. 4, 363. https://doi.org/10.3390/nu9040363

Intake of marine-derived omega-3 polyunsaturated fatty acids and mortality in renal transplant recipients. / Gomes Neto, António; Sotomayor, Camilo; Pranger, Ilse; Van Den Berg, Else; Gans, Rijk; Soedamah-Muthu, S.S.; Navis, Gerjan; Bakker, Stephan.

In: Nutrients, Vol. 9, No. 4, 363, 2017.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Intake of marine-derived omega-3 polyunsaturated fatty acids and mortality in renal transplant recipients

AU - Gomes Neto, António

AU - Sotomayor, Camilo

AU - Pranger, Ilse

AU - Van Den Berg, Else

AU - Gans, Rijk

AU - Soedamah-Muthu, S.S.

AU - Navis, Gerjan

AU - Bakker, Stephan

PY - 2017

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N2 - The effect of marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFA) on long-term outcome in renal transplant recipients (RTR) remains unclear. We investigated whether marine-derived n-3 PUFA intake is associated with all-cause and cardiovascular (CV) mortality in RTR. Intake of eicosapentaenoic acid plus docosahexaenoic acid (EPA-DHA) was assessed using a validated Food Frequency Questionnaire. Cox regression analyses were performed to evaluate the associations of EPA-DHA intake with all-cause and CV mortality. We included 627 RTR (age 53 13 years). EPA-DHA intake was 102 (42–215) mg/day. During median follow-up of 5.4 years, 130 (21%) RTR died, with 52 (8.3%) due to CV causes. EPA-DHA intake was associated with lower risk of all-cause mortality (Hazard Ratio (HR) 0.85; 95% confidence interval (95% CI) 0.75–0.97). Age (p = 0.03) and smoking status (p = 0.01) significantly modified this association, with lower risk of all-cause and CV mortality particularly in older (HR 0.75, 95% CI 0.61–0.92; HR 0.68, 95% CI 0.48–0.95) and non-smoking RTR (HR 0.80, 95% CI 0.68–0.93; HR 0.74, 95% CI 0.56–0.98). In conclusion, marine-derived n-3 PUFA intake is inversely associated with risk of all-cause and CV mortality in RTR. The strongest associations were present in subgroups of patients, which adds further evidence to the plea for EPA-DHA supplementation, particularly in elderly and non-smoking RTR

AB - The effect of marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFA) on long-term outcome in renal transplant recipients (RTR) remains unclear. We investigated whether marine-derived n-3 PUFA intake is associated with all-cause and cardiovascular (CV) mortality in RTR. Intake of eicosapentaenoic acid plus docosahexaenoic acid (EPA-DHA) was assessed using a validated Food Frequency Questionnaire. Cox regression analyses were performed to evaluate the associations of EPA-DHA intake with all-cause and CV mortality. We included 627 RTR (age 53 13 years). EPA-DHA intake was 102 (42–215) mg/day. During median follow-up of 5.4 years, 130 (21%) RTR died, with 52 (8.3%) due to CV causes. EPA-DHA intake was associated with lower risk of all-cause mortality (Hazard Ratio (HR) 0.85; 95% confidence interval (95% CI) 0.75–0.97). Age (p = 0.03) and smoking status (p = 0.01) significantly modified this association, with lower risk of all-cause and CV mortality particularly in older (HR 0.75, 95% CI 0.61–0.92; HR 0.68, 95% CI 0.48–0.95) and non-smoking RTR (HR 0.80, 95% CI 0.68–0.93; HR 0.74, 95% CI 0.56–0.98). In conclusion, marine-derived n-3 PUFA intake is inversely associated with risk of all-cause and CV mortality in RTR. The strongest associations were present in subgroups of patients, which adds further evidence to the plea for EPA-DHA supplementation, particularly in elderly and non-smoking RTR

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DO - 10.3390/nu9040363

M3 - Article

VL - 9

JO - Nutrients

JF - Nutrients

SN - 2072-6643

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