International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer

S. Wheelwright, A.S. Darlington, D. Fitzsimmons, P. Fayers, J.I. Arraras, F. Bonnetain, E. Brain, F. Bredart, W.C. Chie, J. Giesinger, E. Hammerlid, S.J. O'Connor, S. Oerlemans, A. Pallis, M. Reed, N. Singhal, Y. Vassiliou, T. Young, C. Johnson

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Abstract

Background:
Older people represent the majority of cancer patients but their specific needs are often ignored in the development of health-related quality of life (HRQOL) instruments. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-ELD15 was developed to supplement the EORTC’s core questionnaire, the QLQ-C30, for measuring HRQOL in patients aged >70 years in oncology studies.
Methods:
Patients (n=518) from 10 countries completed the QLQ-C30, QLQ-ELD15 and a debriefing interview. Eighty two clinically stable patients repeated the questionnaires 1 week later (test–retest analysis) and 107 others, with an expected change in clinical status, repeated the questionnaires 3 months later (response to change analysis, RCA).
Results:
Information from the debriefing interview, factor analysis and item response theory analysis resulted in the removal of one item (QLQ-ELD15→QLQ-ELD14) and revision of the proposed scale structure to five scales (mobility, worries about others, future worries, maintaining purpose and illness burden) and two single items (joint stiffness and family support). Convergent validity was good. In known-group comparisons, the QLQ-ELD14 differentiated between patients with different disease stage, treatment intention, number of comorbidities, performance status and geriatric screening scores. Test–retest and RCA analyses were equivocal.
Conclusion:
The QLQ-ELD14 is a validated HRQOL questionnaire for cancer patients aged ⩾70 years. Changes in elderly patients’ self-reported HRQOL may be related to both cancer evolution and non-clinical events.
Original languageEnglish
Pages (from-to)852-858
JournalThe British Journal of Cancer
Volume109
Issue number4
DOIs
Publication statusPublished - 2013

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Organizations
Neoplasms
Interviews
Cost of Illness
Surveys and Questionnaires
Geriatrics
Statistical Factor Analysis
Comorbidity

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Wheelwright, S., Darlington, A. S., Fitzsimmons, D., Fayers, P., Arraras, J. I., Bonnetain, F., ... Johnson, C. (2013). International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer. The British Journal of Cancer, 109(4), 852-858. https://doi.org/10.1038/bjc.2013.407
Wheelwright, S. ; Darlington, A.S. ; Fitzsimmons, D. ; Fayers, P. ; Arraras, J.I. ; Bonnetain, F. ; Brain, E. ; Bredart, F. ; Chie, W.C. ; Giesinger, J. ; Hammerlid, E. ; O'Connor, S.J. ; Oerlemans, S. ; Pallis, A. ; Reed, M. ; Singhal, N. ; Vassiliou, Y. ; Young, T. ; Johnson, C. / International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer. In: The British Journal of Cancer. 2013 ; Vol. 109, No. 4. pp. 852-858.
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title = "International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer",
abstract = "Background:Older people represent the majority of cancer patients but their specific needs are often ignored in the development of health-related quality of life (HRQOL) instruments. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-ELD15 was developed to supplement the EORTC’s core questionnaire, the QLQ-C30, for measuring HRQOL in patients aged >70 years in oncology studies.Methods:Patients (n=518) from 10 countries completed the QLQ-C30, QLQ-ELD15 and a debriefing interview. Eighty two clinically stable patients repeated the questionnaires 1 week later (test–retest analysis) and 107 others, with an expected change in clinical status, repeated the questionnaires 3 months later (response to change analysis, RCA).Results:Information from the debriefing interview, factor analysis and item response theory analysis resulted in the removal of one item (QLQ-ELD15→QLQ-ELD14) and revision of the proposed scale structure to five scales (mobility, worries about others, future worries, maintaining purpose and illness burden) and two single items (joint stiffness and family support). Convergent validity was good. In known-group comparisons, the QLQ-ELD14 differentiated between patients with different disease stage, treatment intention, number of comorbidities, performance status and geriatric screening scores. Test–retest and RCA analyses were equivocal.Conclusion:The QLQ-ELD14 is a validated HRQOL questionnaire for cancer patients aged ⩾70 years. Changes in elderly patients’ self-reported HRQOL may be related to both cancer evolution and non-clinical events.",
author = "S. Wheelwright and A.S. Darlington and D. Fitzsimmons and P. Fayers and J.I. Arraras and F. Bonnetain and E. Brain and F. Bredart and W.C. Chie and J. Giesinger and E. Hammerlid and S.J. O'Connor and S. Oerlemans and A. Pallis and M. Reed and N. Singhal and Y. Vassiliou and T. Young and C. Johnson",
year = "2013",
doi = "10.1038/bjc.2013.407",
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journal = "The British Journal of Cancer",
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Wheelwright, S, Darlington, AS, Fitzsimmons, D, Fayers, P, Arraras, JI, Bonnetain, F, Brain, E, Bredart, F, Chie, WC, Giesinger, J, Hammerlid, E, O'Connor, SJ, Oerlemans, S, Pallis, A, Reed, M, Singhal, N, Vassiliou, Y, Young, T & Johnson, C 2013, 'International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer', The British Journal of Cancer, vol. 109, no. 4, pp. 852-858. https://doi.org/10.1038/bjc.2013.407

International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer. / Wheelwright, S.; Darlington, A.S.; Fitzsimmons, D.; Fayers, P.; Arraras, J.I.; Bonnetain, F.; Brain, E.; Bredart, F.; Chie, W.C.; Giesinger, J.; Hammerlid, E.; O'Connor, S.J.; Oerlemans, S.; Pallis, A.; Reed, M.; Singhal, N.; Vassiliou, Y.; Young, T.; Johnson, C.

In: The British Journal of Cancer, Vol. 109, No. 4, 2013, p. 852-858.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer

AU - Wheelwright, S.

AU - Darlington, A.S.

AU - Fitzsimmons, D.

AU - Fayers, P.

AU - Arraras, J.I.

AU - Bonnetain, F.

AU - Brain, E.

AU - Bredart, F.

AU - Chie, W.C.

AU - Giesinger, J.

AU - Hammerlid, E.

AU - O'Connor, S.J.

AU - Oerlemans, S.

AU - Pallis, A.

AU - Reed, M.

AU - Singhal, N.

AU - Vassiliou, Y.

AU - Young, T.

AU - Johnson, C.

PY - 2013

Y1 - 2013

N2 - Background:Older people represent the majority of cancer patients but their specific needs are often ignored in the development of health-related quality of life (HRQOL) instruments. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-ELD15 was developed to supplement the EORTC’s core questionnaire, the QLQ-C30, for measuring HRQOL in patients aged >70 years in oncology studies.Methods:Patients (n=518) from 10 countries completed the QLQ-C30, QLQ-ELD15 and a debriefing interview. Eighty two clinically stable patients repeated the questionnaires 1 week later (test–retest analysis) and 107 others, with an expected change in clinical status, repeated the questionnaires 3 months later (response to change analysis, RCA).Results:Information from the debriefing interview, factor analysis and item response theory analysis resulted in the removal of one item (QLQ-ELD15→QLQ-ELD14) and revision of the proposed scale structure to five scales (mobility, worries about others, future worries, maintaining purpose and illness burden) and two single items (joint stiffness and family support). Convergent validity was good. In known-group comparisons, the QLQ-ELD14 differentiated between patients with different disease stage, treatment intention, number of comorbidities, performance status and geriatric screening scores. Test–retest and RCA analyses were equivocal.Conclusion:The QLQ-ELD14 is a validated HRQOL questionnaire for cancer patients aged ⩾70 years. Changes in elderly patients’ self-reported HRQOL may be related to both cancer evolution and non-clinical events.

AB - Background:Older people represent the majority of cancer patients but their specific needs are often ignored in the development of health-related quality of life (HRQOL) instruments. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-ELD15 was developed to supplement the EORTC’s core questionnaire, the QLQ-C30, for measuring HRQOL in patients aged >70 years in oncology studies.Methods:Patients (n=518) from 10 countries completed the QLQ-C30, QLQ-ELD15 and a debriefing interview. Eighty two clinically stable patients repeated the questionnaires 1 week later (test–retest analysis) and 107 others, with an expected change in clinical status, repeated the questionnaires 3 months later (response to change analysis, RCA).Results:Information from the debriefing interview, factor analysis and item response theory analysis resulted in the removal of one item (QLQ-ELD15→QLQ-ELD14) and revision of the proposed scale structure to five scales (mobility, worries about others, future worries, maintaining purpose and illness burden) and two single items (joint stiffness and family support). Convergent validity was good. In known-group comparisons, the QLQ-ELD14 differentiated between patients with different disease stage, treatment intention, number of comorbidities, performance status and geriatric screening scores. Test–retest and RCA analyses were equivocal.Conclusion:The QLQ-ELD14 is a validated HRQOL questionnaire for cancer patients aged ⩾70 years. Changes in elderly patients’ self-reported HRQOL may be related to both cancer evolution and non-clinical events.

U2 - 10.1038/bjc.2013.407

DO - 10.1038/bjc.2013.407

M3 - Article

VL - 109

SP - 852

EP - 858

JO - The British Journal of Cancer

JF - The British Journal of Cancer

SN - 0007-0920

IS - 4

ER -