Interventions for cognitive problems in adults with brain cancer: A narrative review

Pearl J C van Lonkhuizen, Kete M Klaver, Jeffrey S Wefel, Margriet M Sitskoorn, Sanne B Schagen, Karin Gehring

Research output: Contribution to journalReview articleScientificpeer-review

Abstract

Introduction: 

Many patients with brain cancer experience cognitive problems. In this narrative review, we comprehensively evaluated empirical studies on various intervention approaches for cognitive problems in these patients.

Methods: 

Intervention studies that reported effects on cognitive functioning (either objectively tested or subjectively reported) in adult patients with primary and/or secondary brain tumours were identified through online searches in PubMed (MEDLINE) and Web of Science up to 13 March 2019.

Results: 

Of the 364 identified records, 10 pharmacological (including five randomised placebo-controlled trials), 10 cognitive rehabilitation (including five [pilot] RCTs) and two multiple-group exercise studies matched the inclusion criteria. Seventeen of 22 studies had final sample sizes smaller than 40. Several cognitive rehabilitation studies and some pharmacological approaches (donepezil and memantine) showed (at least partial) benefits for cognitive problems in adults with brain cancer. The effects of other pharmacological and exercise interventions were inconclusive and/or preliminary.

Conclusions: 

Overall, drawing firm conclusions is complicated due to various methodological shortcomings, including the absence of a (placebo) control group and small sample sizes. Promising effects have been reported for cognitive rehabilitation and some pharmacological approaches. Suggestions for more thorough research with respect to the various approaches are provided.

Original languageEnglish
Article number13088
JournalEuropean Journal of Cancer Care
Volume28
Issue number3
DOIs
Publication statusPublished - 2019

Fingerprint

Placebos
Exercise
Memantine
PubMed
MEDLINE
donepezil

Keywords

  • DEFICITS
  • DONEPEZIL
  • DOUBLE-BLIND
  • EXERCISE PROGRAM
  • GLIOMAS
  • PHASE-III
  • RADIATION
  • REHABILITATION
  • SURVIVAL
  • TUMOR PATIENTS
  • brain neoplasms
  • cognition
  • exercise therapy
  • neoplasm metastasis
  • pharmacology
  • rehabilitation

Cite this

@article{02727c6325d342159ecd6f4ed3c64b3e,
title = "Interventions for cognitive problems in adults with brain cancer: A narrative review",
abstract = "Introduction: Many patients with brain cancer experience cognitive problems. In this narrative review, we comprehensively evaluated empirical studies on various intervention approaches for cognitive problems in these patients.Methods: Intervention studies that reported effects on cognitive functioning (either objectively tested or subjectively reported) in adult patients with primary and/or secondary brain tumours were identified through online searches in PubMed (MEDLINE) and Web of Science up to 13 March 2019.Results: Of the 364 identified records, 10 pharmacological (including five randomised placebo-controlled trials), 10 cognitive rehabilitation (including five [pilot] RCTs) and two multiple-group exercise studies matched the inclusion criteria. Seventeen of 22 studies had final sample sizes smaller than 40. Several cognitive rehabilitation studies and some pharmacological approaches (donepezil and memantine) showed (at least partial) benefits for cognitive problems in adults with brain cancer. The effects of other pharmacological and exercise interventions were inconclusive and/or preliminary.Conclusions: Overall, drawing firm conclusions is complicated due to various methodological shortcomings, including the absence of a (placebo) control group and small sample sizes. Promising effects have been reported for cognitive rehabilitation and some pharmacological approaches. Suggestions for more thorough research with respect to the various approaches are provided.",
keywords = "DEFICITS, DONEPEZIL, DOUBLE-BLIND, EXERCISE PROGRAM, GLIOMAS, PHASE-III, RADIATION, REHABILITATION, SURVIVAL, TUMOR PATIENTS, brain neoplasms, cognition, exercise therapy, neoplasm metastasis, pharmacology, rehabilitation",
author = "{van Lonkhuizen}, {Pearl J C} and Klaver, {Kete M} and Wefel, {Jeffrey S} and Sitskoorn, {Margriet M} and Schagen, {Sanne B} and Karin Gehring",
note = "{\circledC} 2019 The Authors. European Journal of Cancer Care Published by John Wiley & Sons Ltd.",
year = "2019",
doi = "10.1111/ecc.13088",
language = "English",
volume = "28",
journal = "European Journal of Cancer Care",
issn = "0961-5423",
publisher = "Wiley-Blackwell",
number = "3",

}

Interventions for cognitive problems in adults with brain cancer : A narrative review. / van Lonkhuizen, Pearl J C; Klaver, Kete M; Wefel, Jeffrey S; Sitskoorn, Margriet M; Schagen, Sanne B; Gehring, Karin.

In: European Journal of Cancer Care, Vol. 28, No. 3, 13088, 2019.

Research output: Contribution to journalReview articleScientificpeer-review

TY - JOUR

T1 - Interventions for cognitive problems in adults with brain cancer

T2 - A narrative review

AU - van Lonkhuizen, Pearl J C

AU - Klaver, Kete M

AU - Wefel, Jeffrey S

AU - Sitskoorn, Margriet M

AU - Schagen, Sanne B

AU - Gehring, Karin

N1 - © 2019 The Authors. European Journal of Cancer Care Published by John Wiley & Sons Ltd.

PY - 2019

Y1 - 2019

N2 - Introduction: Many patients with brain cancer experience cognitive problems. In this narrative review, we comprehensively evaluated empirical studies on various intervention approaches for cognitive problems in these patients.Methods: Intervention studies that reported effects on cognitive functioning (either objectively tested or subjectively reported) in adult patients with primary and/or secondary brain tumours were identified through online searches in PubMed (MEDLINE) and Web of Science up to 13 March 2019.Results: Of the 364 identified records, 10 pharmacological (including five randomised placebo-controlled trials), 10 cognitive rehabilitation (including five [pilot] RCTs) and two multiple-group exercise studies matched the inclusion criteria. Seventeen of 22 studies had final sample sizes smaller than 40. Several cognitive rehabilitation studies and some pharmacological approaches (donepezil and memantine) showed (at least partial) benefits for cognitive problems in adults with brain cancer. The effects of other pharmacological and exercise interventions were inconclusive and/or preliminary.Conclusions: Overall, drawing firm conclusions is complicated due to various methodological shortcomings, including the absence of a (placebo) control group and small sample sizes. Promising effects have been reported for cognitive rehabilitation and some pharmacological approaches. Suggestions for more thorough research with respect to the various approaches are provided.

AB - Introduction: Many patients with brain cancer experience cognitive problems. In this narrative review, we comprehensively evaluated empirical studies on various intervention approaches for cognitive problems in these patients.Methods: Intervention studies that reported effects on cognitive functioning (either objectively tested or subjectively reported) in adult patients with primary and/or secondary brain tumours were identified through online searches in PubMed (MEDLINE) and Web of Science up to 13 March 2019.Results: Of the 364 identified records, 10 pharmacological (including five randomised placebo-controlled trials), 10 cognitive rehabilitation (including five [pilot] RCTs) and two multiple-group exercise studies matched the inclusion criteria. Seventeen of 22 studies had final sample sizes smaller than 40. Several cognitive rehabilitation studies and some pharmacological approaches (donepezil and memantine) showed (at least partial) benefits for cognitive problems in adults with brain cancer. The effects of other pharmacological and exercise interventions were inconclusive and/or preliminary.Conclusions: Overall, drawing firm conclusions is complicated due to various methodological shortcomings, including the absence of a (placebo) control group and small sample sizes. Promising effects have been reported for cognitive rehabilitation and some pharmacological approaches. Suggestions for more thorough research with respect to the various approaches are provided.

KW - DEFICITS

KW - DONEPEZIL

KW - DOUBLE-BLIND

KW - EXERCISE PROGRAM

KW - GLIOMAS

KW - PHASE-III

KW - RADIATION

KW - REHABILITATION

KW - SURVIVAL

KW - TUMOR PATIENTS

KW - brain neoplasms

KW - cognition

KW - exercise therapy

KW - neoplasm metastasis

KW - pharmacology

KW - rehabilitation

U2 - 10.1111/ecc.13088

DO - 10.1111/ecc.13088

M3 - Review article

VL - 28

JO - European Journal of Cancer Care

JF - European Journal of Cancer Care

SN - 0961-5423

IS - 3

M1 - 13088

ER -