Lesion symptom mapping at the regional level in patients with a meningioma

W. De Baene*, S.J.M. Rijnen, K. Gehring, Ikram Meskal, G.J.M. Rutten, M.M. Sitskoorn

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Objective: 

The majority of meningioma patients suffer from presurgical cognitive deficits. Since meningiomas do not directly damage the brain, this is presumably caused by a functional integrity reduction of the surrounding brain tissue through perilesional edema and/or mass effect of the tumor. Tumor location is a key feature in determining neurological symptoms in brain tumor patients, but the relationship between meningioma location and cognitive performance remains unclear. This study aimed to identify brain areas where the presence of a meningioma forms a potential risk factor for worse cognitive performance as compared to meningiomas at other locations. 

Method: 

Neuropsychological data (CNS Vital Signs) and MRI were collected in 224 meningioma patients one day before surgery. Sociodemographically corrected scores were calculated for 7 cognitive domains. Tumors were semiautomatically segmented and mapped into MNI-space for use in Statistical Region of Interest analyses. For each cognitive domain, we tested whether larger proportions of tumor overlap with each of the 150 defined regions were associated with worse performance. 

Results: 

After multiple comparison (Bonferroni) and lesion volume correction, larger proportions of tumor overlap with both the left middle and superior frontal gyms were associated with worse complex attention scores. Larger proportions of tumor overlap with the left middle frontal gyms were associated with worse cognitive flexibility scores. For the other domains, no association between tumor overlap with a region and cognitive performance was found. 

Conclusions: 

The current results suggest that, compared to patients with a meningioma at other locations, patients with a meningioma at the left middle frontal gyrus are at potential risk for worse performance on cognitive flexibility and complex attention whereas patients with a meningioma at the left superior frontal gyms are at potential risk for worse performance on complex attention.

Original languageEnglish
Pages (from-to)103-110
JournalNeuropsychology
Volume33
Issue number1
DOIs
Publication statusPublished - 2019

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Meningioma
Neoplasms
Vital Signs
Ambulatory Surgical Procedures

Keywords

  • lesion symptom mapping
  • meningioma
  • tumor overlap
  • cognitive flexibility
  • complex attention
  • BRAIN
  • AGE
  • NETWORK
  • LOCALIZATION
  • SURGERY

Cite this

@article{6d4f5e4d7386471f8ca3db2e002e68b1,
title = "Lesion symptom mapping at the regional level in patients with a meningioma",
abstract = "Objective: The majority of meningioma patients suffer from presurgical cognitive deficits. Since meningiomas do not directly damage the brain, this is presumably caused by a functional integrity reduction of the surrounding brain tissue through perilesional edema and/or mass effect of the tumor. Tumor location is a key feature in determining neurological symptoms in brain tumor patients, but the relationship between meningioma location and cognitive performance remains unclear. This study aimed to identify brain areas where the presence of a meningioma forms a potential risk factor for worse cognitive performance as compared to meningiomas at other locations. Method: Neuropsychological data (CNS Vital Signs) and MRI were collected in 224 meningioma patients one day before surgery. Sociodemographically corrected scores were calculated for 7 cognitive domains. Tumors were semiautomatically segmented and mapped into MNI-space for use in Statistical Region of Interest analyses. For each cognitive domain, we tested whether larger proportions of tumor overlap with each of the 150 defined regions were associated with worse performance. Results: After multiple comparison (Bonferroni) and lesion volume correction, larger proportions of tumor overlap with both the left middle and superior frontal gyms were associated with worse complex attention scores. Larger proportions of tumor overlap with the left middle frontal gyms were associated with worse cognitive flexibility scores. For the other domains, no association between tumor overlap with a region and cognitive performance was found. Conclusions: The current results suggest that, compared to patients with a meningioma at other locations, patients with a meningioma at the left middle frontal gyrus are at potential risk for worse performance on cognitive flexibility and complex attention whereas patients with a meningioma at the left superior frontal gyms are at potential risk for worse performance on complex attention.",
keywords = "lesion symptom mapping, meningioma, tumor overlap, cognitive flexibility, complex attention, BRAIN, AGE, NETWORK, LOCALIZATION, SURGERY",
author = "{De Baene}, W. and S.J.M. Rijnen and K. Gehring and Ikram Meskal and G.J.M. Rutten and M.M. Sitskoorn",
year = "2019",
doi = "10.1037/neu0000490",
language = "English",
volume = "33",
pages = "103--110",
journal = "Neuropsychology",
issn = "0894-4105",
publisher = "AMER PSYCHOLOGICAL ASSOC",
number = "1",

}

Lesion symptom mapping at the regional level in patients with a meningioma. / De Baene, W.; Rijnen, S.J.M.; Gehring, K.; Meskal, Ikram; Rutten, G.J.M.; Sitskoorn, M.M.

In: Neuropsychology, Vol. 33, No. 1, 2019, p. 103-110.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Lesion symptom mapping at the regional level in patients with a meningioma

AU - De Baene, W.

AU - Rijnen, S.J.M.

AU - Gehring, K.

AU - Meskal, Ikram

AU - Rutten, G.J.M.

AU - Sitskoorn, M.M.

PY - 2019

Y1 - 2019

N2 - Objective: The majority of meningioma patients suffer from presurgical cognitive deficits. Since meningiomas do not directly damage the brain, this is presumably caused by a functional integrity reduction of the surrounding brain tissue through perilesional edema and/or mass effect of the tumor. Tumor location is a key feature in determining neurological symptoms in brain tumor patients, but the relationship between meningioma location and cognitive performance remains unclear. This study aimed to identify brain areas where the presence of a meningioma forms a potential risk factor for worse cognitive performance as compared to meningiomas at other locations. Method: Neuropsychological data (CNS Vital Signs) and MRI were collected in 224 meningioma patients one day before surgery. Sociodemographically corrected scores were calculated for 7 cognitive domains. Tumors were semiautomatically segmented and mapped into MNI-space for use in Statistical Region of Interest analyses. For each cognitive domain, we tested whether larger proportions of tumor overlap with each of the 150 defined regions were associated with worse performance. Results: After multiple comparison (Bonferroni) and lesion volume correction, larger proportions of tumor overlap with both the left middle and superior frontal gyms were associated with worse complex attention scores. Larger proportions of tumor overlap with the left middle frontal gyms were associated with worse cognitive flexibility scores. For the other domains, no association between tumor overlap with a region and cognitive performance was found. Conclusions: The current results suggest that, compared to patients with a meningioma at other locations, patients with a meningioma at the left middle frontal gyrus are at potential risk for worse performance on cognitive flexibility and complex attention whereas patients with a meningioma at the left superior frontal gyms are at potential risk for worse performance on complex attention.

AB - Objective: The majority of meningioma patients suffer from presurgical cognitive deficits. Since meningiomas do not directly damage the brain, this is presumably caused by a functional integrity reduction of the surrounding brain tissue through perilesional edema and/or mass effect of the tumor. Tumor location is a key feature in determining neurological symptoms in brain tumor patients, but the relationship between meningioma location and cognitive performance remains unclear. This study aimed to identify brain areas where the presence of a meningioma forms a potential risk factor for worse cognitive performance as compared to meningiomas at other locations. Method: Neuropsychological data (CNS Vital Signs) and MRI were collected in 224 meningioma patients one day before surgery. Sociodemographically corrected scores were calculated for 7 cognitive domains. Tumors were semiautomatically segmented and mapped into MNI-space for use in Statistical Region of Interest analyses. For each cognitive domain, we tested whether larger proportions of tumor overlap with each of the 150 defined regions were associated with worse performance. Results: After multiple comparison (Bonferroni) and lesion volume correction, larger proportions of tumor overlap with both the left middle and superior frontal gyms were associated with worse complex attention scores. Larger proportions of tumor overlap with the left middle frontal gyms were associated with worse cognitive flexibility scores. For the other domains, no association between tumor overlap with a region and cognitive performance was found. Conclusions: The current results suggest that, compared to patients with a meningioma at other locations, patients with a meningioma at the left middle frontal gyrus are at potential risk for worse performance on cognitive flexibility and complex attention whereas patients with a meningioma at the left superior frontal gyms are at potential risk for worse performance on complex attention.

KW - lesion symptom mapping

KW - meningioma

KW - tumor overlap

KW - cognitive flexibility

KW - complex attention

KW - BRAIN

KW - AGE

KW - NETWORK

KW - LOCALIZATION

KW - SURGERY

U2 - 10.1037/neu0000490

DO - 10.1037/neu0000490

M3 - Article

VL - 33

SP - 103

EP - 110

JO - Neuropsychology

JF - Neuropsychology

SN - 0894-4105

IS - 1

ER -