Leukocyte telomere length and personality: Associations with the big five and type d personality traits

D. Schoormans, J.E. Verhoeven, J. Denollet, L.V. van de Poll-Franse, B.W.J.H. Penninx

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)
7 Downloads (Pure)

Abstract

Backgrounds: 

Accelerated cellular ageing, which can be examined by telomere length (TL), may be an overarching mechanism underlying the association between personality and adverse health outcomes. This 6-year longitudinal study examined the relation between personality and leukocyte telomere length (LTL) across time among adults with a wide age-range.

Methods: 

Data from the Netherlands Study of Depression and Anxiety were used and included patients with a depression and/or anxiety disorder and healthy controls. Overall, 2936 persons (18-65 years, 66% female) had data on LTL at baseline and 1883 persons had LTL at 6-year follow-up. The Big Five personality traits (neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness) and Type D personality were assessed.

Results:

Neuroticism was negatively (B = -2.11, p = 0.03) and agreeableness was positively (B = 3.84, p = 0.03) related to LTL measured across two time points, which became just non-significant after adjusting for somatic health, lifestyle factors, and recent life stress (B = -1.99, p = 0.06; and B = 3.01, p = 0.10). Type D personality was negatively (B = -50.16, p < 0.01) related to LTL across two time points, which still remained statistically significant after full adjustment (B = -47.37, p = 0.01). Associations did not differ by age, gender, and current psychiatric status.

Conclusions: 

The Big Five traits high neuroticism and low agreeableness, and Type D personality were associated with shorter LTL measured across a 6-year period. Associations with the Big Five traits became non-significant after controlling for somatic health, lifestyle factors, and recent life stress, yet similar trends were observed. Type D personality remained independently associated with shorter LTL after full adjustment.

Original languageEnglish
Pages (from-to)1008-1019
JournalPsychological Medicine
Volume48
Issue number6
DOIs
Publication statusPublished - 2018

Keywords

  • 5-FACTOR MODEL
  • ALL-CAUSE MORTALITY
  • ANXIETY DISORDERS
  • Big Five
  • CHRONIC HEART-FAILURE
  • DISEASE
  • LIFE EVENTS
  • MYOCARDIAL-INFARCTION
  • NEGATIVE AFFECTIVITY
  • RISK-FACTORS
  • SOCIAL INHIBITION
  • Type D personality
  • cellular aging
  • leukocyte telomere length
  • personality

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