Life-threatening infections in children in Europe (the EUCLIDS Project)

A prospective cohort study

F. Martinón-Torres, A. Salas, I. Rivero-Calle, M. Cebey-López, J. Pardo-Seco, J.A. Herberg, N.P. Boeddha, D.S. Klobassa, F. Secka, S. Paulus, R. de Groot, L.J. Schlapbach , G.J. Driessen, S.T. Anderson, M. Emonts, W. Zenz, E.D. Carrol , M. Van der Flier, M. Levin, E. de Vries

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background: 
Sepsis and severe focal infections represent a substantial disease burden in children admitted to hospital. We aimed to understand the burden of disease and outcomes in children with life-threatening bacterial infections in Europe.
Methods: 
The European Union Childhood Life-threatening Infectious Disease Study (EUCLIDS) was a prospective, multicentre, cohort study done in six countries in Europe. Patients aged 1 month to 18 years with sepsis (or suspected sepsis) or severe focal infections, admitted to 98 participating hospitals in the UK, Austria, Germany, Lithuania, Spain, and the Netherlands were prospectively recruited between July 1, 2012, and Dec 31, 2015. To assess disease burden and outcomes, we collected demographic and clinical data using a secured web-based platform and obtained microbiological data using locally available clinical diagnostic procedures.
Findings: 
2844 patients were recruited and included in the analysis. 1512 (53·2%) of 2841 patients were male and median age was 39·1 months (IQR 12·4-93·9). 1229 (43·2%) patients had sepsis and 1615 (56·8%) had severe focal infections. Patients diagnosed with sepsis had a median age of 27·6 months (IQR 9·0-80·2), whereas those diagnosed with severe focal infections had a median age of 46·5 months (15·8-100·4; p<0·0001). Of 2844 patients in the entire cohort, the main clinical syndromes were pneumonia (511 [18·0%] patients), CNS infection (469 [16·5%]), and skin and soft tissue infection (247 [8·7%]). The causal microorganism was identified in 1359 (47·8%) children, with the most prevalent ones being Neisseria meningitidis (in 259 [9·1%] patients), followed by Staphylococcus aureus (in 222 [7·8%]), Streptococcus pneumoniae (in 219 [7·7%]), and group A streptococcus (in 162 [5·7%]). 1070 (37·6%) patients required admission to a paediatric intensive care unit. Of 2469 patients with outcome data, 57 (2·2%) deaths occurred: seven were in patients with severe focal infections and 50 in those with sepsis.
Interpretation: 
Mortality in children admitted to hospital for sepsis or severe focal infections is low in Europe. The disease burden is mainly in children younger than 5 years and is largely due to vaccine-preventable meningococcal and pneumococcal infections. Despite the availability and application of clinical procedures for microbiological diagnosis, the causative organism remained unidentified in approximately 50% of patients.
Original languageEnglish
Pages (from-to)404-414
Journal The Lancet Child & Adolescent Health
Volume2
Issue number6
DOIs
Publication statusPublished - 2018

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European Union
Lithuania
Child Mortality
Pediatric Intensive Care Units
Soft Tissue Infections
Patient Admission
Netherlands
Multicenter Studies
Germany

Cite this

Martinón-Torres, F. ; Salas, A. ; Rivero-Calle, I. ; Cebey-López, M. ; Pardo-Seco, J. ; Herberg, J.A. ; Boeddha, N.P. ; Klobassa, D.S. ; Secka, F. ; Paulus, S. ; de Groot, R. ; Schlapbach , L.J. ; Driessen, G.J. ; Anderson, S.T. ; Emonts, M. ; Zenz, W. ; Carrol , E.D. ; Van der Flier, M. ; Levin, M. ; de Vries, E. / Life-threatening infections in children in Europe (the EUCLIDS Project) : A prospective cohort study. In: The Lancet Child & Adolescent Health. 2018 ; Vol. 2, No. 6. pp. 404-414.
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title = "Life-threatening infections in children in Europe (the EUCLIDS Project): A prospective cohort study",
abstract = "Background: Sepsis and severe focal infections represent a substantial disease burden in children admitted to hospital. We aimed to understand the burden of disease and outcomes in children with life-threatening bacterial infections in Europe.Methods: The European Union Childhood Life-threatening Infectious Disease Study (EUCLIDS) was a prospective, multicentre, cohort study done in six countries in Europe. Patients aged 1 month to 18 years with sepsis (or suspected sepsis) or severe focal infections, admitted to 98 participating hospitals in the UK, Austria, Germany, Lithuania, Spain, and the Netherlands were prospectively recruited between July 1, 2012, and Dec 31, 2015. To assess disease burden and outcomes, we collected demographic and clinical data using a secured web-based platform and obtained microbiological data using locally available clinical diagnostic procedures.Findings: 2844 patients were recruited and included in the analysis. 1512 (53·2{\%}) of 2841 patients were male and median age was 39·1 months (IQR 12·4-93·9). 1229 (43·2{\%}) patients had sepsis and 1615 (56·8{\%}) had severe focal infections. Patients diagnosed with sepsis had a median age of 27·6 months (IQR 9·0-80·2), whereas those diagnosed with severe focal infections had a median age of 46·5 months (15·8-100·4; p<0·0001). Of 2844 patients in the entire cohort, the main clinical syndromes were pneumonia (511 [18·0{\%}] patients), CNS infection (469 [16·5{\%}]), and skin and soft tissue infection (247 [8·7{\%}]). The causal microorganism was identified in 1359 (47·8{\%}) children, with the most prevalent ones being Neisseria meningitidis (in 259 [9·1{\%}] patients), followed by Staphylococcus aureus (in 222 [7·8{\%}]), Streptococcus pneumoniae (in 219 [7·7{\%}]), and group A streptococcus (in 162 [5·7{\%}]). 1070 (37·6{\%}) patients required admission to a paediatric intensive care unit. Of 2469 patients with outcome data, 57 (2·2{\%}) deaths occurred: seven were in patients with severe focal infections and 50 in those with sepsis.Interpretation: Mortality in children admitted to hospital for sepsis or severe focal infections is low in Europe. The disease burden is mainly in children younger than 5 years and is largely due to vaccine-preventable meningococcal and pneumococcal infections. Despite the availability and application of clinical procedures for microbiological diagnosis, the causative organism remained unidentified in approximately 50{\%} of patients.",
author = "F. Martin{\'o}n-Torres and A. Salas and I. Rivero-Calle and M. Cebey-L{\'o}pez and J. Pardo-Seco and J.A. Herberg and N.P. Boeddha and D.S. Klobassa and F. Secka and S. Paulus and {de Groot}, R. and L.J. Schlapbach and G.J. Driessen and S.T. Anderson and M. Emonts and W. Zenz and E.D. Carrol and {Van der Flier}, M. and M. Levin and {de Vries}, E.",
year = "2018",
doi = "10.1016/S2352-4642(18)30113-5",
language = "English",
volume = "2",
pages = "404--414",
journal = "The Lancet Child & Adolescent Health",
issn = "2352-4642",
publisher = "Elsevier BV",
number = "6",

}

Martinón-Torres, F, Salas, A, Rivero-Calle, I, Cebey-López, M, Pardo-Seco, J, Herberg, JA, Boeddha, NP, Klobassa, DS, Secka, F, Paulus, S, de Groot, R, Schlapbach , LJ, Driessen, GJ, Anderson, ST, Emonts, M, Zenz, W, Carrol , ED, Van der Flier, M, Levin, M & de Vries, E 2018, 'Life-threatening infections in children in Europe (the EUCLIDS Project): A prospective cohort study', The Lancet Child & Adolescent Health, vol. 2, no. 6, pp. 404-414. https://doi.org/10.1016/S2352-4642(18)30113-5

Life-threatening infections in children in Europe (the EUCLIDS Project) : A prospective cohort study. / Martinón-Torres, F.; Salas, A.; Rivero-Calle, I.; Cebey-López, M.; Pardo-Seco, J.; Herberg, J.A.; Boeddha, N.P.; Klobassa, D.S.; Secka, F.; Paulus, S.; de Groot, R.; Schlapbach , L.J.; Driessen, G.J.; Anderson, S.T.; Emonts, M.; Zenz, W.; Carrol , E.D.; Van der Flier, M.; Levin, M.; de Vries, E.

In: The Lancet Child & Adolescent Health, Vol. 2, No. 6, 2018, p. 404-414.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Life-threatening infections in children in Europe (the EUCLIDS Project)

T2 - A prospective cohort study

AU - Martinón-Torres, F.

AU - Salas, A.

AU - Rivero-Calle, I.

AU - Cebey-López, M.

AU - Pardo-Seco, J.

AU - Herberg, J.A.

AU - Boeddha, N.P.

AU - Klobassa, D.S.

AU - Secka, F.

AU - Paulus, S.

AU - de Groot, R.

AU - Schlapbach , L.J.

AU - Driessen, G.J.

AU - Anderson, S.T.

AU - Emonts, M.

AU - Zenz, W.

AU - Carrol , E.D.

AU - Van der Flier, M.

AU - Levin, M.

AU - de Vries, E.

PY - 2018

Y1 - 2018

N2 - Background: Sepsis and severe focal infections represent a substantial disease burden in children admitted to hospital. We aimed to understand the burden of disease and outcomes in children with life-threatening bacterial infections in Europe.Methods: The European Union Childhood Life-threatening Infectious Disease Study (EUCLIDS) was a prospective, multicentre, cohort study done in six countries in Europe. Patients aged 1 month to 18 years with sepsis (or suspected sepsis) or severe focal infections, admitted to 98 participating hospitals in the UK, Austria, Germany, Lithuania, Spain, and the Netherlands were prospectively recruited between July 1, 2012, and Dec 31, 2015. To assess disease burden and outcomes, we collected demographic and clinical data using a secured web-based platform and obtained microbiological data using locally available clinical diagnostic procedures.Findings: 2844 patients were recruited and included in the analysis. 1512 (53·2%) of 2841 patients were male and median age was 39·1 months (IQR 12·4-93·9). 1229 (43·2%) patients had sepsis and 1615 (56·8%) had severe focal infections. Patients diagnosed with sepsis had a median age of 27·6 months (IQR 9·0-80·2), whereas those diagnosed with severe focal infections had a median age of 46·5 months (15·8-100·4; p<0·0001). Of 2844 patients in the entire cohort, the main clinical syndromes were pneumonia (511 [18·0%] patients), CNS infection (469 [16·5%]), and skin and soft tissue infection (247 [8·7%]). The causal microorganism was identified in 1359 (47·8%) children, with the most prevalent ones being Neisseria meningitidis (in 259 [9·1%] patients), followed by Staphylococcus aureus (in 222 [7·8%]), Streptococcus pneumoniae (in 219 [7·7%]), and group A streptococcus (in 162 [5·7%]). 1070 (37·6%) patients required admission to a paediatric intensive care unit. Of 2469 patients with outcome data, 57 (2·2%) deaths occurred: seven were in patients with severe focal infections and 50 in those with sepsis.Interpretation: Mortality in children admitted to hospital for sepsis or severe focal infections is low in Europe. The disease burden is mainly in children younger than 5 years and is largely due to vaccine-preventable meningococcal and pneumococcal infections. Despite the availability and application of clinical procedures for microbiological diagnosis, the causative organism remained unidentified in approximately 50% of patients.

AB - Background: Sepsis and severe focal infections represent a substantial disease burden in children admitted to hospital. We aimed to understand the burden of disease and outcomes in children with life-threatening bacterial infections in Europe.Methods: The European Union Childhood Life-threatening Infectious Disease Study (EUCLIDS) was a prospective, multicentre, cohort study done in six countries in Europe. Patients aged 1 month to 18 years with sepsis (or suspected sepsis) or severe focal infections, admitted to 98 participating hospitals in the UK, Austria, Germany, Lithuania, Spain, and the Netherlands were prospectively recruited between July 1, 2012, and Dec 31, 2015. To assess disease burden and outcomes, we collected demographic and clinical data using a secured web-based platform and obtained microbiological data using locally available clinical diagnostic procedures.Findings: 2844 patients were recruited and included in the analysis. 1512 (53·2%) of 2841 patients were male and median age was 39·1 months (IQR 12·4-93·9). 1229 (43·2%) patients had sepsis and 1615 (56·8%) had severe focal infections. Patients diagnosed with sepsis had a median age of 27·6 months (IQR 9·0-80·2), whereas those diagnosed with severe focal infections had a median age of 46·5 months (15·8-100·4; p<0·0001). Of 2844 patients in the entire cohort, the main clinical syndromes were pneumonia (511 [18·0%] patients), CNS infection (469 [16·5%]), and skin and soft tissue infection (247 [8·7%]). The causal microorganism was identified in 1359 (47·8%) children, with the most prevalent ones being Neisseria meningitidis (in 259 [9·1%] patients), followed by Staphylococcus aureus (in 222 [7·8%]), Streptococcus pneumoniae (in 219 [7·7%]), and group A streptococcus (in 162 [5·7%]). 1070 (37·6%) patients required admission to a paediatric intensive care unit. Of 2469 patients with outcome data, 57 (2·2%) deaths occurred: seven were in patients with severe focal infections and 50 in those with sepsis.Interpretation: Mortality in children admitted to hospital for sepsis or severe focal infections is low in Europe. The disease burden is mainly in children younger than 5 years and is largely due to vaccine-preventable meningococcal and pneumococcal infections. Despite the availability and application of clinical procedures for microbiological diagnosis, the causative organism remained unidentified in approximately 50% of patients.

U2 - 10.1016/S2352-4642(18)30113-5

DO - 10.1016/S2352-4642(18)30113-5

M3 - Article

VL - 2

SP - 404

EP - 414

JO - The Lancet Child & Adolescent Health

JF - The Lancet Child & Adolescent Health

SN - 2352-4642

IS - 6

ER -