Local recurrence following breast-conserving treatment in women aged 40 years or younger

Trends in risk and the impact on prognosis in a population-based cohort of 1143 patients

C. van Laar, M. J. C. van der Sangen, P. M. P. Poortmans, G. A. P. Nieuwenhuijzen, J. A. Roukema, R. M. H. Roumen, V. C. G. Tjan-Heijnen, A. C. Voogd

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Aim
To evaluate trends in the risk of local recurrences after breast-conserving treatment (BCT) and to examine the impact of local recurrence (LR) on distant relapse-free survival in a large, population-based cohort of women aged ⩽40 years with early-stage breast cancer.
Methods
All women (n = 1143) aged ⩽40 years with early-stage (pT1-2/cT1-2, N0-2, M0) breast cancer who underwent BCT in the south of the Netherlands between 1988 and 2010 were included. BCT consisted of local excision of the tumour followed by irradiation of the breast.
Results
After a median follow-up of 8.5 (0.1–24.6) years, 176 patients had developed an isolated LR. The 5-year LR-rate for the subgroups treated in the periods 1988–1998, 1999–2005 and 2006–2010 were 9.8% (95% confidence interval (CI) 7.1–12.5), 5.9% (95% CI 3.2–8.6) and 3.3% (95% CI 0.6–6.0), respectively (p = 0.006). In a multivariate analysis, adjuvant systemic treatment was associated with a reduced risk of LR of almost 60% (hazard ratio (HR) 0.42; 95% CI 0.28–0.60; p < 0.0001). Patients who experienced an early isolated LR (⩽5 years after BCT) had a worse distant relapse-free survival compared to patients without an early LR (HR 1.83; 95% CI 1.27–2.64; p = 0.001). Late local recurrences did not negatively affect distant relapse-free survival (HR 1.24; 95% CI 0.74–2.08; p = 0.407).
Conclusion
Local control after BCT improved significantly over time and appeared to be closely related to the increased use and effectiveness of systemic therapy. These recent results underline the safety of BCT for young women with early-stage breast cancer.Keywords: Breast carcinoma, Breast-conservation, Local recurrence, Prognosis, Risk, Young age
Original languageEnglish
Pages (from-to)3093-3101
JournalEuropean Journal of Cancer: Official journal for European Organization for Research and Treatment of Cancer (EORTC)
Volume49
Issue number15
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Breast carcinoma
  • Breast-conservation
  • Local recurrence
  • Prognosis
  • Risk
  • Young age

Cite this

@article{5df79b5fa8a24a028fb5b2288aceefa7,
title = "Local recurrence following breast-conserving treatment in women aged 40 years or younger: Trends in risk and the impact on prognosis in a population-based cohort of 1143 patients",
abstract = "AimTo evaluate trends in the risk of local recurrences after breast-conserving treatment (BCT) and to examine the impact of local recurrence (LR) on distant relapse-free survival in a large, population-based cohort of women aged ⩽40 years with early-stage breast cancer.MethodsAll women (n = 1143) aged ⩽40 years with early-stage (pT1-2/cT1-2, N0-2, M0) breast cancer who underwent BCT in the south of the Netherlands between 1988 and 2010 were included. BCT consisted of local excision of the tumour followed by irradiation of the breast.ResultsAfter a median follow-up of 8.5 (0.1–24.6) years, 176 patients had developed an isolated LR. The 5-year LR-rate for the subgroups treated in the periods 1988–1998, 1999–2005 and 2006–2010 were 9.8{\%} (95{\%} confidence interval (CI) 7.1–12.5), 5.9{\%} (95{\%} CI 3.2–8.6) and 3.3{\%} (95{\%} CI 0.6–6.0), respectively (p = 0.006). In a multivariate analysis, adjuvant systemic treatment was associated with a reduced risk of LR of almost 60{\%} (hazard ratio (HR) 0.42; 95{\%} CI 0.28–0.60; p < 0.0001). Patients who experienced an early isolated LR (⩽5 years after BCT) had a worse distant relapse-free survival compared to patients without an early LR (HR 1.83; 95{\%} CI 1.27–2.64; p = 0.001). Late local recurrences did not negatively affect distant relapse-free survival (HR 1.24; 95{\%} CI 0.74–2.08; p = 0.407).ConclusionLocal control after BCT improved significantly over time and appeared to be closely related to the increased use and effectiveness of systemic therapy. These recent results underline the safety of BCT for young women with early-stage breast cancer.Keywords: Breast carcinoma, Breast-conservation, Local recurrence, Prognosis, Risk, Young age",
keywords = "Breast carcinoma, Breast-conservation, Local recurrence, Prognosis, Risk, Young age",
author = "{van Laar}, C. and {van der Sangen}, {M. J. C.} and Poortmans, {P. M. P.} and Nieuwenhuijzen, {G. A. P.} and Roukema, {J. A.} and Roumen, {R. M. H.} and Tjan-Heijnen, {V. C. G.} and Voogd, {A. C.}",
note = "Geen affiliatie met TiU",
year = "2013",
month = "10",
doi = "10.1016/j.ejca.2013.05.030",
language = "English",
volume = "49",
pages = "3093--3101",
journal = "European Journal of Cancer: Official journal for European Organization for Research and Treatment of Cancer (EORTC)",
issn = "0959-8049",
publisher = "ELSEVIER SCI LTD",
number = "15",

}

Local recurrence following breast-conserving treatment in women aged 40 years or younger : Trends in risk and the impact on prognosis in a population-based cohort of 1143 patients. / van Laar, C.; van der Sangen, M. J. C.; Poortmans, P. M. P.; Nieuwenhuijzen, G. A. P.; Roukema, J. A.; Roumen, R. M. H.; Tjan-Heijnen, V. C. G.; Voogd, A. C.

In: European Journal of Cancer: Official journal for European Organization for Research and Treatment of Cancer (EORTC), Vol. 49, No. 15, 10.2013, p. 3093-3101.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Local recurrence following breast-conserving treatment in women aged 40 years or younger

T2 - Trends in risk and the impact on prognosis in a population-based cohort of 1143 patients

AU - van Laar, C.

AU - van der Sangen, M. J. C.

AU - Poortmans, P. M. P.

AU - Nieuwenhuijzen, G. A. P.

AU - Roukema, J. A.

AU - Roumen, R. M. H.

AU - Tjan-Heijnen, V. C. G.

AU - Voogd, A. C.

N1 - Geen affiliatie met TiU

PY - 2013/10

Y1 - 2013/10

N2 - AimTo evaluate trends in the risk of local recurrences after breast-conserving treatment (BCT) and to examine the impact of local recurrence (LR) on distant relapse-free survival in a large, population-based cohort of women aged ⩽40 years with early-stage breast cancer.MethodsAll women (n = 1143) aged ⩽40 years with early-stage (pT1-2/cT1-2, N0-2, M0) breast cancer who underwent BCT in the south of the Netherlands between 1988 and 2010 were included. BCT consisted of local excision of the tumour followed by irradiation of the breast.ResultsAfter a median follow-up of 8.5 (0.1–24.6) years, 176 patients had developed an isolated LR. The 5-year LR-rate for the subgroups treated in the periods 1988–1998, 1999–2005 and 2006–2010 were 9.8% (95% confidence interval (CI) 7.1–12.5), 5.9% (95% CI 3.2–8.6) and 3.3% (95% CI 0.6–6.0), respectively (p = 0.006). In a multivariate analysis, adjuvant systemic treatment was associated with a reduced risk of LR of almost 60% (hazard ratio (HR) 0.42; 95% CI 0.28–0.60; p < 0.0001). Patients who experienced an early isolated LR (⩽5 years after BCT) had a worse distant relapse-free survival compared to patients without an early LR (HR 1.83; 95% CI 1.27–2.64; p = 0.001). Late local recurrences did not negatively affect distant relapse-free survival (HR 1.24; 95% CI 0.74–2.08; p = 0.407).ConclusionLocal control after BCT improved significantly over time and appeared to be closely related to the increased use and effectiveness of systemic therapy. These recent results underline the safety of BCT for young women with early-stage breast cancer.Keywords: Breast carcinoma, Breast-conservation, Local recurrence, Prognosis, Risk, Young age

AB - AimTo evaluate trends in the risk of local recurrences after breast-conserving treatment (BCT) and to examine the impact of local recurrence (LR) on distant relapse-free survival in a large, population-based cohort of women aged ⩽40 years with early-stage breast cancer.MethodsAll women (n = 1143) aged ⩽40 years with early-stage (pT1-2/cT1-2, N0-2, M0) breast cancer who underwent BCT in the south of the Netherlands between 1988 and 2010 were included. BCT consisted of local excision of the tumour followed by irradiation of the breast.ResultsAfter a median follow-up of 8.5 (0.1–24.6) years, 176 patients had developed an isolated LR. The 5-year LR-rate for the subgroups treated in the periods 1988–1998, 1999–2005 and 2006–2010 were 9.8% (95% confidence interval (CI) 7.1–12.5), 5.9% (95% CI 3.2–8.6) and 3.3% (95% CI 0.6–6.0), respectively (p = 0.006). In a multivariate analysis, adjuvant systemic treatment was associated with a reduced risk of LR of almost 60% (hazard ratio (HR) 0.42; 95% CI 0.28–0.60; p < 0.0001). Patients who experienced an early isolated LR (⩽5 years after BCT) had a worse distant relapse-free survival compared to patients without an early LR (HR 1.83; 95% CI 1.27–2.64; p = 0.001). Late local recurrences did not negatively affect distant relapse-free survival (HR 1.24; 95% CI 0.74–2.08; p = 0.407).ConclusionLocal control after BCT improved significantly over time and appeared to be closely related to the increased use and effectiveness of systemic therapy. These recent results underline the safety of BCT for young women with early-stage breast cancer.Keywords: Breast carcinoma, Breast-conservation, Local recurrence, Prognosis, Risk, Young age

KW - Breast carcinoma

KW - Breast-conservation

KW - Local recurrence

KW - Prognosis

KW - Risk

KW - Young age

U2 - 10.1016/j.ejca.2013.05.030

DO - 10.1016/j.ejca.2013.05.030

M3 - Article

VL - 49

SP - 3093

EP - 3101

JO - European Journal of Cancer: Official journal for European Organization for Research and Treatment of Cancer (EORTC)

JF - European Journal of Cancer: Official journal for European Organization for Research and Treatment of Cancer (EORTC)

SN - 0959-8049

IS - 15

ER -