Long-term impact of endometrial cancer diagnosis and treatment on health-related quality of life and cancer survivorship: Results from the randomized PORTEC-2 trial

Stephanie M. de Boer, Remi A. Nout, Ina M. Jurgenliemk-Schulz, Jan J. Jobsen, Ludy C. H. W. Lutgens, Elzbieta M. van der Steen-Banasik, Jan Willem M. Mens, Annerie Slot, Marika C. Stenfert Kroese, Simone Oerlemans, Hein Putter, Karen W. Verhoeven-Adema, Hans W. Nijman, Carien L. Creutzberg

Research output: Contribution to journalArticleScientificpeer-review

41 Citations (Scopus)
20 Downloads (Pure)

Abstract

Purpose
To evaluate the long-term health-related quality of life (HRQL) after external beam radiation therapy (EBRT) or vaginal brachytherapy (VBT) among PORTEC-2 trial patients, evaluate long-term bowel and bladder symptoms, and assess the impact of cancer on these endometrial cancer (EC) survivors.Patients and 
Methods
In the PORTEC-2 trial, 427 patients with stage I high–intermediate-risk EC were randomly allocated to EBRT or VBT. The 7- and 10-year HRQL questionnaires consisted of EORTC QLQ-C30; subscales for bowel and bladder symptoms; the Impact of Cancer Questionnaire; and 14 questions on comorbidities, walking aids, and incontinence pads. Analysis was done using linear mixed models for subscales and (ordinal) logistic regression with random effects for single items. A two-sided P value <.01 was considered statistically significant.ResultsLongitudinal HRQL analysis showed persisting higher rates of bowel symptoms with EBRT, without significant differences in global health or any of the functioning scales. At 7 years, clinically relevant fecal leakage was reported by 10.6% in the EBRT group, versus 1.8% for VBT (P=.03), diarrhea by 8.4% versus 0.9% (P=.04), limitations due to bowel symptoms by 10.5% versus 1.8% (P=.001), and bowel urgency by 23.3% versus 6.6% (P<.001). Urinary urgency was reported by 39.3% of EBRT patients, 25.5% for VBT, P=.05. No difference in sexual activity was seen between treatment arms. Long-term impact of cancer scores was higher among the patients who had an EC recurrence or second cancer.
Conclusions
More than 7 years after treatment, EBRT patients reported more bowel symptoms with impact on daily activities, and a trend for more urinary symptoms, without impact on overall quality of life or difference in cancer survivorship issues.
Original languageEnglish
Pages (from-to)797-809
JournalInternational Journal of Radiation Oncology Biology Physics
Volume93
Issue number4
DOIs
Publication statusPublished - 2015

Cite this

de Boer, S. M., Nout, R. A., Jurgenliemk-Schulz, I. M., Jobsen, J. J., Lutgens, L. C. H. W., van der Steen-Banasik, E. M., Mens, J. W. M., Slot, A., Kroese, M. C. S., Oerlemans, S., Putter, H., Verhoeven-Adema, K. W., Nijman, H. W., & Creutzberg, C. L. (2015). Long-term impact of endometrial cancer diagnosis and treatment on health-related quality of life and cancer survivorship: Results from the randomized PORTEC-2 trial. International Journal of Radiation Oncology Biology Physics, 93(4), 797-809. https://doi.org/10.1016/j.ijrobp.2015.08.023