Long-term outcome and quality of life after arterial switch operation

A prospective study with a historical comparison

T.P.E. Ruys, A.E.M. van der Bosch , J.A.A.E. Cuypers, M. Witsenburg, W.A. Helbing, A.J.J.C. Bogers, R.T. van Domburg, J.S. McGhie, M.L. Geleijnse, J. Henrichs, E. Utens, H.B. van der Zwaan, J.J.M. Takkenberg, J.W. Roos-Hesselink

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Aim.
The study aims to describe the long-term cardiological and psychological results of our first surgical cohort of arterial switch operation (ASO) patients and compare the results with our earlier series of Mustard patients.
Methods.
Twenty-four survivors of ASO operated in our center (1985–1990) were evaluated by electrocardiography, echocardiography, magnetic resonance imaging, exercise testing, 24-hour Holter-monitoring, and health-related quality of life questionnaire. The results were compared with 58 adult Mustard patients who were evaluated in 2001 using the same study protocol.
Results.
Arterial switch operation was performed at a median age of 13 days and Mustard operation at 2 years. Median follow-up was 22 years (range 20–25) and 25 years (22–29), respectively. After ASO, survival was better (P =.04). The event-free survival after 22 years was 77% after ASO vs. 44% after Mustard (P =.03). Good systemic ventricular function was present in 93% after ASO vs. 6% after Mustard (P <.01). Exercise capacity in ASO was 85% of predicted, compared with 72% in Mustard patients (P =.01). Aortic regurgitation was found in 21% of ASO patients vs. 16% in Mustard patients. Arterial switch patients vs. Mustard patients reported significantly better quality of life and less somatic complaints.
Conclusion.
The progression made in surgical treatment for transposition of the great arteries from Mustard to ASO has had a positive impact on survival, cardiac function, exercise capacity, and also self-reported quality of life and somatic complaints. Longer follow-up is warranted to monitor aortic regurgitation.
Original languageEnglish
Pages (from-to)203-210
JournalCongenital Heart Disease
Volume8
Issue number3
DOIs
Publication statusPublished - 2013

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Mustard Plant
Exercise
Arterial Switch Operation
Ambulatory Electrocardiography
Disease-Free Survival
Survivors
Echocardiography
Electrocardiography

Cite this

Ruys, T. P. E., van der Bosch , A. E. M., Cuypers, J. A. A. E., Witsenburg, M., Helbing, W. A., Bogers, A. J. J. C., ... Roos-Hesselink, J. W. (2013). Long-term outcome and quality of life after arterial switch operation: A prospective study with a historical comparison. Congenital Heart Disease , 8(3), 203-210. https://doi.org/10.1111/chd.12033
Ruys, T.P.E. ; van der Bosch , A.E.M. ; Cuypers, J.A.A.E. ; Witsenburg, M. ; Helbing, W.A. ; Bogers, A.J.J.C. ; van Domburg, R.T. ; McGhie, J.S. ; Geleijnse, M.L. ; Henrichs, J. ; Utens, E. ; van der Zwaan, H.B. ; Takkenberg, J.J.M. ; Roos-Hesselink, J.W. / Long-term outcome and quality of life after arterial switch operation : A prospective study with a historical comparison. In: Congenital Heart Disease . 2013 ; Vol. 8, No. 3. pp. 203-210.
@article{3127791242d34cf4942398710dfa23e7,
title = "Long-term outcome and quality of life after arterial switch operation: A prospective study with a historical comparison",
abstract = "Aim.The study aims to describe the long-term cardiological and psychological results of our first surgical cohort of arterial switch operation (ASO) patients and compare the results with our earlier series of Mustard patients.Methods.Twenty-four survivors of ASO operated in our center (1985–1990) were evaluated by electrocardiography, echocardiography, magnetic resonance imaging, exercise testing, 24-hour Holter-monitoring, and health-related quality of life questionnaire. The results were compared with 58 adult Mustard patients who were evaluated in 2001 using the same study protocol.Results.Arterial switch operation was performed at a median age of 13 days and Mustard operation at 2 years. Median follow-up was 22 years (range 20–25) and 25 years (22–29), respectively. After ASO, survival was better (P =.04). The event-free survival after 22 years was 77{\%} after ASO vs. 44{\%} after Mustard (P =.03). Good systemic ventricular function was present in 93{\%} after ASO vs. 6{\%} after Mustard (P <.01). Exercise capacity in ASO was 85{\%} of predicted, compared with 72{\%} in Mustard patients (P =.01). Aortic regurgitation was found in 21{\%} of ASO patients vs. 16{\%} in Mustard patients. Arterial switch patients vs. Mustard patients reported significantly better quality of life and less somatic complaints.Conclusion.The progression made in surgical treatment for transposition of the great arteries from Mustard to ASO has had a positive impact on survival, cardiac function, exercise capacity, and also self-reported quality of life and somatic complaints. Longer follow-up is warranted to monitor aortic regurgitation.",
author = "T.P.E. Ruys and {van der Bosch}, A.E.M. and J.A.A.E. Cuypers and M. Witsenburg and W.A. Helbing and A.J.J.C. Bogers and {van Domburg}, R.T. and J.S. McGhie and M.L. Geleijnse and J. Henrichs and E. Utens and {van der Zwaan}, H.B. and J.J.M. Takkenberg and J.W. Roos-Hesselink",
year = "2013",
doi = "10.1111/chd.12033",
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volume = "8",
pages = "203--210",
journal = "Congenital Heart Disease",
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Ruys, TPE, van der Bosch , AEM, Cuypers, JAAE, Witsenburg, M, Helbing, WA, Bogers, AJJC, van Domburg, RT, McGhie, JS, Geleijnse, ML, Henrichs, J, Utens, E, van der Zwaan, HB, Takkenberg, JJM & Roos-Hesselink, JW 2013, 'Long-term outcome and quality of life after arterial switch operation: A prospective study with a historical comparison', Congenital Heart Disease , vol. 8, no. 3, pp. 203-210. https://doi.org/10.1111/chd.12033

Long-term outcome and quality of life after arterial switch operation : A prospective study with a historical comparison. / Ruys, T.P.E.; van der Bosch , A.E.M.; Cuypers, J.A.A.E.; Witsenburg, M.; Helbing, W.A.; Bogers, A.J.J.C.; van Domburg, R.T.; McGhie, J.S.; Geleijnse, M.L.; Henrichs, J.; Utens, E.; van der Zwaan, H.B.; Takkenberg, J.J.M.; Roos-Hesselink, J.W.

In: Congenital Heart Disease , Vol. 8, No. 3, 2013, p. 203-210.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Long-term outcome and quality of life after arterial switch operation

T2 - A prospective study with a historical comparison

AU - Ruys, T.P.E.

AU - van der Bosch , A.E.M.

AU - Cuypers, J.A.A.E.

AU - Witsenburg, M.

AU - Helbing, W.A.

AU - Bogers, A.J.J.C.

AU - van Domburg, R.T.

AU - McGhie, J.S.

AU - Geleijnse, M.L.

AU - Henrichs, J.

AU - Utens, E.

AU - van der Zwaan, H.B.

AU - Takkenberg, J.J.M.

AU - Roos-Hesselink, J.W.

PY - 2013

Y1 - 2013

N2 - Aim.The study aims to describe the long-term cardiological and psychological results of our first surgical cohort of arterial switch operation (ASO) patients and compare the results with our earlier series of Mustard patients.Methods.Twenty-four survivors of ASO operated in our center (1985–1990) were evaluated by electrocardiography, echocardiography, magnetic resonance imaging, exercise testing, 24-hour Holter-monitoring, and health-related quality of life questionnaire. The results were compared with 58 adult Mustard patients who were evaluated in 2001 using the same study protocol.Results.Arterial switch operation was performed at a median age of 13 days and Mustard operation at 2 years. Median follow-up was 22 years (range 20–25) and 25 years (22–29), respectively. After ASO, survival was better (P =.04). The event-free survival after 22 years was 77% after ASO vs. 44% after Mustard (P =.03). Good systemic ventricular function was present in 93% after ASO vs. 6% after Mustard (P <.01). Exercise capacity in ASO was 85% of predicted, compared with 72% in Mustard patients (P =.01). Aortic regurgitation was found in 21% of ASO patients vs. 16% in Mustard patients. Arterial switch patients vs. Mustard patients reported significantly better quality of life and less somatic complaints.Conclusion.The progression made in surgical treatment for transposition of the great arteries from Mustard to ASO has had a positive impact on survival, cardiac function, exercise capacity, and also self-reported quality of life and somatic complaints. Longer follow-up is warranted to monitor aortic regurgitation.

AB - Aim.The study aims to describe the long-term cardiological and psychological results of our first surgical cohort of arterial switch operation (ASO) patients and compare the results with our earlier series of Mustard patients.Methods.Twenty-four survivors of ASO operated in our center (1985–1990) were evaluated by electrocardiography, echocardiography, magnetic resonance imaging, exercise testing, 24-hour Holter-monitoring, and health-related quality of life questionnaire. The results were compared with 58 adult Mustard patients who were evaluated in 2001 using the same study protocol.Results.Arterial switch operation was performed at a median age of 13 days and Mustard operation at 2 years. Median follow-up was 22 years (range 20–25) and 25 years (22–29), respectively. After ASO, survival was better (P =.04). The event-free survival after 22 years was 77% after ASO vs. 44% after Mustard (P =.03). Good systemic ventricular function was present in 93% after ASO vs. 6% after Mustard (P <.01). Exercise capacity in ASO was 85% of predicted, compared with 72% in Mustard patients (P =.01). Aortic regurgitation was found in 21% of ASO patients vs. 16% in Mustard patients. Arterial switch patients vs. Mustard patients reported significantly better quality of life and less somatic complaints.Conclusion.The progression made in surgical treatment for transposition of the great arteries from Mustard to ASO has had a positive impact on survival, cardiac function, exercise capacity, and also self-reported quality of life and somatic complaints. Longer follow-up is warranted to monitor aortic regurgitation.

U2 - 10.1111/chd.12033

DO - 10.1111/chd.12033

M3 - Article

VL - 8

SP - 203

EP - 210

JO - Congenital Heart Disease

JF - Congenital Heart Disease

SN - 1873-734X

IS - 3

ER -