TY - JOUR
T1 - Longitudinal associations of adherence to the world cancer research fund/american institute for cancer research (wcrf/aicr) lifestyle recommendations with quality of life and symptoms in colorectal cancer survivors up to 24 Months post-treatment
AU - Kenkhuis, M.F.
AU - Mols, F.
AU - van Roekel, E.H.
AU - Breedveld - Peters, J.J.L.
AU - Breukink, S.O.
AU - Janssen-Heijnen, M.L.G.
AU - Keulen, E.T.P.
AU - van Duijnhoven, F.J.B.
AU - Weijenberg, M.P.
AU - Bours, M.J.L.
N1 - This study was funded by the Wereld Kanker Onderzoek Fonds (WKOF)/World Cancer Research Fund (WCRF: 2017/1619). M. Kenkhuis is supported by a grant from WKOF/WCRF 2017/1619. The EnCoRe study was also supported by Stichting Alpe d’Huzes within the research program “Leven met kanker” of the Dutch Cancer Society grants UM 2010-4867 and UM 2012-5653, by ERA-NET on Translational Cancer Research (TRANSCAN: Dutch Cancer Society (UM 2014-6877), and by Kankeronderzoekfonds Limburg as part of Health Foundation Limburg grant 00005739. E.H. van Roekel is funded by WKOF/WCRF 2016/1620.
PY - 2022
Y1 - 2022
N2 - Post-treatment adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In a prospective cohort among CRC survivors (n = 459), repeated home-visits were performed at 6 weeks, 6, 12, and 24 months post-treatment. Dietary intake, body composition, sedentary behaviour, and physical activity were assessed to construct a lifestyle score based on adherence to seven 2018 WCRF/AICR recommendations. Longitudinal associations of the lifestyle score with HRQoL, fatigue, and CIPN were analysed by confounder-adjusted linear mixed models. A higher lifestyle score was associated with better physical functioning and less activity-related fatigue, but not with CIPN. Adjustment for physical activity substantially attenuated observed associations, indicating its importance in the lifestyle score with regards to HRQoL. In contrast, adjustment for body composition and alcohol inflated observed associations, indicating that both recommendations had a counteractive influence within the lifestyle score. Our findings suggest that CRC survivors benefit from an overall adherence to the WCRF/AICR lifestyle recommendations in terms of HRQoL and fatigue, but not CIPN. Specific recommendations have a varying influence on these associations, complicating the interpretation and requiring further study
AB - Post-treatment adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In a prospective cohort among CRC survivors (n = 459), repeated home-visits were performed at 6 weeks, 6, 12, and 24 months post-treatment. Dietary intake, body composition, sedentary behaviour, and physical activity were assessed to construct a lifestyle score based on adherence to seven 2018 WCRF/AICR recommendations. Longitudinal associations of the lifestyle score with HRQoL, fatigue, and CIPN were analysed by confounder-adjusted linear mixed models. A higher lifestyle score was associated with better physical functioning and less activity-related fatigue, but not with CIPN. Adjustment for physical activity substantially attenuated observed associations, indicating its importance in the lifestyle score with regards to HRQoL. In contrast, adjustment for body composition and alcohol inflated observed associations, indicating that both recommendations had a counteractive influence within the lifestyle score. Our findings suggest that CRC survivors benefit from an overall adherence to the WCRF/AICR lifestyle recommendations in terms of HRQoL and fatigue, but not CIPN. Specific recommendations have a varying influence on these associations, complicating the interpretation and requiring further study
KW - CHEMOTHERAPY
KW - DIET
KW - EORTC QLQ-C30
KW - EUROPEAN-ORGANIZATION
KW - FATIGUE
KW - HEALTH
KW - INDUCED PERIPHERAL NEUROPATHY
KW - PHYSICAL-ACTIVITY
KW - QUESTIONNAIRE
KW - VALIDATION
KW - chemotherapy-induced peripheral neuropathy
KW - colorectal cancer survivorship
KW - fatigue
KW - health-related quality of life
KW - lifestyle recommendations
UR - http://www.scopus.com/inward/record.url?scp=85122888769&partnerID=8YFLogxK
U2 - 10.3390/cancers14020417
DO - 10.3390/cancers14020417
M3 - Article
SN - 2072-6694
VL - 14
JO - Cancers
JF - Cancers
IS - 2
M1 - 417
ER -