Longitudinal associations of fast foods, red and processed meat, alcohol, and sugar-sweetened drinks with quality of life and symptoms in colorectal cancer survivors up to 24 months post-treatment

M.F. Kenkhuis*, F. Mols, E.H. van Roekel, J.J.L. Breedveld - Peters, S.O. Breukink, M..G. Janssen-Heijnen, E.T.P. Keulen, F.J.B. van Duijnhoven, M.P. Weijenberg, M.J.L. Bours

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Unhealthy dietary habits can contribute to the development of colorectal cancer (CRC). Such habits may also be associated with post-treatment symptoms experienced by CRC survivors. Therefore, we aimed to assess longitudinal associations of post-treatment unhealthy dietary habits, i.e., intake of ultra-processed foods (UPF), red and processed meat, alcohol, and sugar-sweetened drinks, with health-related quality of life (HRQoL), fatigue and chemotherapy-induced peripheral neuropathy (CIPN) in CRC survivors from 6 weeks up to 24 months post-treatment. In a prospective cohort among stage I-III CRC survivors (n=396), five repeated home visits from diagnosis up to 24 months post-treatment were executed. Dietary intake was measured by 7-day dietary records to quantify consumption of UPF, red and processed meat, alcohol, and sugar-sweetened drinks. HRQoL, fatigue and CIPN were measured by validated questionnaires. We applied confounder-adjusted linear mixed-models to analyse longitudinal associations from 6 weeks until 24 months post-treatment. We applied a post-hoc time-lag analysis for alcohol to explore the directionality. Results showed that higher post-treatment intake of UPF, and sugar-sweetened drinks were longitudinally associated with worsened HRQoL and more fatigue, while higher intake of UPF and processed meat was associated with increased CIPN symptoms. In contrast, post-treatment increases in alcohol intake were longitudinally associated with better HRQoL and less fatigue, however time-lag analysis attenuated these associations. In conclusion, unhealthy dietary habits are longitudinally associated with lower HRQoL and more symptoms, except for alcohol. Results from time-lag analysis suggest no biological effect of alcohol, hence the longitudinal association for alcohol should be interpreted with caution.
Original languageEnglish
Pages (from-to)114-126
JournalBritish Journal of Nutrition
Volume130
Issue number1
DOIs
Publication statusPublished - 2023

Keywords

  • CHEMOTHERAPY
  • CONSUMPTION
  • Chemotherapy-induced peripheral neuropathy
  • Colorectal cancer survivorship
  • Diet
  • EORTC QLQ-C30
  • EUROPEAN-ORGANIZATION
  • FATIGUE
  • Fatigue
  • HEALTH
  • Health-related quality of life
  • INDUCED PERIPHERAL NEUROPATHY
  • Lifestyle recommendations
  • QUESTIONNAIRE
  • SCORE

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