Looming sensitive cortical regions without V1 input: Evidence from a patient with bilateral cortical blindness

A. Hervais-Adelman, L.B. Legrand, M. Zhan, M. Tamietto, B. de Gelder, A.J. Pegna

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Abstract

Fast and automatic behavioral responses are required to avoid collision with an approaching stimulus. Accordingly, looming stimuli have been found to be highly salient and efficient attractors of attention due to the implication of potential collision and potential threat. Here, we address the question of whether looming motion is processed in the absence of any functional primary visual cortex and consequently without awareness. For this, we investigated a patient (TN) suffering from complete, bilateral damage to his primary visual cortex. Using an fMRI paradigm, we measured TN's brain activation during the presentation of looming, receding, rotating, and static point lights, of which he was unaware. When contrasted with other conditions, looming was found to produce bilateral activation of the middle temporal areas, as well as the superior temporal sulcus and inferior parietal lobe (IPL). The latter are generally thought to be involved in multisensory processing of motion in extrapersonal space, as well as attentional capture and saliency. No activity was found close to the lesioned V1 area. This demonstrates that looming motion is processed in the absence of awareness through direct subcortical projections to areas involved in multisensory processing of motion and saliency that bypass V1.
Original languageEnglish
Article number51
JournalFrontiers in Integrative Neuroscience
Volume9
DOIs
Publication statusPublished - 2015

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title = "Looming sensitive cortical regions without V1 input: Evidence from a patient with bilateral cortical blindness",
abstract = "Fast and automatic behavioral responses are required to avoid collision with an approaching stimulus. Accordingly, looming stimuli have been found to be highly salient and efficient attractors of attention due to the implication of potential collision and potential threat. Here, we address the question of whether looming motion is processed in the absence of any functional primary visual cortex and consequently without awareness. For this, we investigated a patient (TN) suffering from complete, bilateral damage to his primary visual cortex. Using an fMRI paradigm, we measured TN's brain activation during the presentation of looming, receding, rotating, and static point lights, of which he was unaware. When contrasted with other conditions, looming was found to produce bilateral activation of the middle temporal areas, as well as the superior temporal sulcus and inferior parietal lobe (IPL). The latter are generally thought to be involved in multisensory processing of motion in extrapersonal space, as well as attentional capture and saliency. No activity was found close to the lesioned V1 area. This demonstrates that looming motion is processed in the absence of awareness through direct subcortical projections to areas involved in multisensory processing of motion and saliency that bypass V1.",
author = "A. Hervais-Adelman and L.B. Legrand and M. Zhan and M. Tamietto and {de Gelder}, B. and A.J. Pegna",
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language = "English",
volume = "9",
journal = "Frontiers in Integrative Neuroscience",
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Looming sensitive cortical regions without V1 input : Evidence from a patient with bilateral cortical blindness. / Hervais-Adelman, A.; Legrand, L.B.; Zhan, M.; Tamietto, M.; de Gelder, B.; Pegna, A.J.

In: Frontiers in Integrative Neuroscience, Vol. 9, 51, 2015.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Looming sensitive cortical regions without V1 input

T2 - Evidence from a patient with bilateral cortical blindness

AU - Hervais-Adelman, A.

AU - Legrand, L.B.

AU - Zhan, M.

AU - Tamietto, M.

AU - de Gelder, B.

AU - Pegna, A.J.

PY - 2015

Y1 - 2015

N2 - Fast and automatic behavioral responses are required to avoid collision with an approaching stimulus. Accordingly, looming stimuli have been found to be highly salient and efficient attractors of attention due to the implication of potential collision and potential threat. Here, we address the question of whether looming motion is processed in the absence of any functional primary visual cortex and consequently without awareness. For this, we investigated a patient (TN) suffering from complete, bilateral damage to his primary visual cortex. Using an fMRI paradigm, we measured TN's brain activation during the presentation of looming, receding, rotating, and static point lights, of which he was unaware. When contrasted with other conditions, looming was found to produce bilateral activation of the middle temporal areas, as well as the superior temporal sulcus and inferior parietal lobe (IPL). The latter are generally thought to be involved in multisensory processing of motion in extrapersonal space, as well as attentional capture and saliency. No activity was found close to the lesioned V1 area. This demonstrates that looming motion is processed in the absence of awareness through direct subcortical projections to areas involved in multisensory processing of motion and saliency that bypass V1.

AB - Fast and automatic behavioral responses are required to avoid collision with an approaching stimulus. Accordingly, looming stimuli have been found to be highly salient and efficient attractors of attention due to the implication of potential collision and potential threat. Here, we address the question of whether looming motion is processed in the absence of any functional primary visual cortex and consequently without awareness. For this, we investigated a patient (TN) suffering from complete, bilateral damage to his primary visual cortex. Using an fMRI paradigm, we measured TN's brain activation during the presentation of looming, receding, rotating, and static point lights, of which he was unaware. When contrasted with other conditions, looming was found to produce bilateral activation of the middle temporal areas, as well as the superior temporal sulcus and inferior parietal lobe (IPL). The latter are generally thought to be involved in multisensory processing of motion in extrapersonal space, as well as attentional capture and saliency. No activity was found close to the lesioned V1 area. This demonstrates that looming motion is processed in the absence of awareness through direct subcortical projections to areas involved in multisensory processing of motion and saliency that bypass V1.

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DO - 10.3389/fnint.2015.00051

M3 - Article

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JO - Frontiers in Integrative Neuroscience

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SN - 1662-5145

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