Maternal thyrotrophin in euthyroid women is related to meconium stained amniotic fluid in women who deliver at or over 41 weeks of gestation

L. Monen, S.M. Kuppens, T.H. Hasaart, H. Wijnen, V.J.M. Pop

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background
Maternal thyroid dysfunction is of known influence on pregnancies in the preterm period. However little is known about its effect on term and post term pregnancies. Meconium stained amniotic fluid (MSAF) is known to occur preferentially in (post)term pregnancies.
Aims
To assess a possible independent relation between maternal thyroid function and MSAF.Study design and subjects1051 women, in whom thyroid function was assessed at each trimester, were followed prospectively (delivery ≥ 37 weeks). We compared the difference in mean TSH and FT4 between women with (152) and without (899) MSAF using one way ANOVA. Thyroid function was assessed in subgroups regarding gestational age. Finally we performed multiple logistic regression analysis with MSAF as dependent variable and TSH as independent variable adjusting for various confounders.
Results
Maternal thyroid function was not associated with the incidence of MSAF when analysing all deliveries ≥ 37 weeks. However, in the “at-risk” group for MSAF (> 41 weeks), multiple logistic regression showed an independent relation between MSAF and TSH (O.R.: 1.61, 95% CI: 1.10–2.43).
Conclusions
The present study shows that in women delivering ≥ 41 weeks of gestation, higher TSH is independently related to MSAF.
Original languageEnglish
Pages (from-to)329-332
JournalEarly Human Development
Volume90
Issue number7
DOIs
Publication statusPublished - 2014

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Meconium
Amniotic Fluid
Mothers
Logistic Models
Gestational Age
Incidence

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@article{2b2a74f126cb4d6d88f4a04e00b50018,
title = "Maternal thyrotrophin in euthyroid women is related to meconium stained amniotic fluid in women who deliver at or over 41 weeks of gestation",
abstract = "BackgroundMaternal thyroid dysfunction is of known influence on pregnancies in the preterm period. However little is known about its effect on term and post term pregnancies. Meconium stained amniotic fluid (MSAF) is known to occur preferentially in (post)term pregnancies.AimsTo assess a possible independent relation between maternal thyroid function and MSAF.Study design and subjects1051 women, in whom thyroid function was assessed at each trimester, were followed prospectively (delivery ≥ 37 weeks). We compared the difference in mean TSH and FT4 between women with (152) and without (899) MSAF using one way ANOVA. Thyroid function was assessed in subgroups regarding gestational age. Finally we performed multiple logistic regression analysis with MSAF as dependent variable and TSH as independent variable adjusting for various confounders.ResultsMaternal thyroid function was not associated with the incidence of MSAF when analysing all deliveries ≥ 37 weeks. However, in the “at-risk” group for MSAF (> 41 weeks), multiple logistic regression showed an independent relation between MSAF and TSH (O.R.: 1.61, 95{\%} CI: 1.10–2.43).ConclusionsThe present study shows that in women delivering ≥ 41 weeks of gestation, higher TSH is independently related to MSAF.",
author = "L. Monen and S.M. Kuppens and T.H. Hasaart and H. Wijnen and V.J.M. Pop",
year = "2014",
doi = "10.1016/j.earlhumdev.2014.04.002",
language = "English",
volume = "90",
pages = "329--332",
journal = "Early Human Development",
issn = "0378-3782",
publisher = "Elsevier Ireland Ltd",
number = "7",

}

Maternal thyrotrophin in euthyroid women is related to meconium stained amniotic fluid in women who deliver at or over 41 weeks of gestation. / Monen, L.; Kuppens, S.M.; Hasaart, T.H.; Wijnen, H.; Pop, V.J.M.

In: Early Human Development, Vol. 90, No. 7, 2014, p. 329-332.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Maternal thyrotrophin in euthyroid women is related to meconium stained amniotic fluid in women who deliver at or over 41 weeks of gestation

AU - Monen, L.

AU - Kuppens, S.M.

AU - Hasaart, T.H.

AU - Wijnen, H.

AU - Pop, V.J.M.

PY - 2014

Y1 - 2014

N2 - BackgroundMaternal thyroid dysfunction is of known influence on pregnancies in the preterm period. However little is known about its effect on term and post term pregnancies. Meconium stained amniotic fluid (MSAF) is known to occur preferentially in (post)term pregnancies.AimsTo assess a possible independent relation between maternal thyroid function and MSAF.Study design and subjects1051 women, in whom thyroid function was assessed at each trimester, were followed prospectively (delivery ≥ 37 weeks). We compared the difference in mean TSH and FT4 between women with (152) and without (899) MSAF using one way ANOVA. Thyroid function was assessed in subgroups regarding gestational age. Finally we performed multiple logistic regression analysis with MSAF as dependent variable and TSH as independent variable adjusting for various confounders.ResultsMaternal thyroid function was not associated with the incidence of MSAF when analysing all deliveries ≥ 37 weeks. However, in the “at-risk” group for MSAF (> 41 weeks), multiple logistic regression showed an independent relation between MSAF and TSH (O.R.: 1.61, 95% CI: 1.10–2.43).ConclusionsThe present study shows that in women delivering ≥ 41 weeks of gestation, higher TSH is independently related to MSAF.

AB - BackgroundMaternal thyroid dysfunction is of known influence on pregnancies in the preterm period. However little is known about its effect on term and post term pregnancies. Meconium stained amniotic fluid (MSAF) is known to occur preferentially in (post)term pregnancies.AimsTo assess a possible independent relation between maternal thyroid function and MSAF.Study design and subjects1051 women, in whom thyroid function was assessed at each trimester, were followed prospectively (delivery ≥ 37 weeks). We compared the difference in mean TSH and FT4 between women with (152) and without (899) MSAF using one way ANOVA. Thyroid function was assessed in subgroups regarding gestational age. Finally we performed multiple logistic regression analysis with MSAF as dependent variable and TSH as independent variable adjusting for various confounders.ResultsMaternal thyroid function was not associated with the incidence of MSAF when analysing all deliveries ≥ 37 weeks. However, in the “at-risk” group for MSAF (> 41 weeks), multiple logistic regression showed an independent relation between MSAF and TSH (O.R.: 1.61, 95% CI: 1.10–2.43).ConclusionsThe present study shows that in women delivering ≥ 41 weeks of gestation, higher TSH is independently related to MSAF.

U2 - 10.1016/j.earlhumdev.2014.04.002

DO - 10.1016/j.earlhumdev.2014.04.002

M3 - Article

VL - 90

SP - 329

EP - 332

JO - Early Human Development

JF - Early Human Development

SN - 0378-3782

IS - 7

ER -