Maternal thyrotropin is independently related to Small for Gestational Age neonates at term

L. Monen, S.M. Kuppens, T.H. Hasaart, H.P. Oosterbaan, S.G. Oei, H. Wijnen, E.K. Hutton, H.L. Vader, V.J.M. Pop

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Objective
Small for gestational age (SGA) newborns constitute still a major cause of perinatal morbidity and mortality. Overt thyroid disease is a known cause of preterm birth and low birthweight but in its untreated condition it is rare today. In this study, we investigated the possible relation between maternal thyroid function assessed in euthyroid women at each trimester and the incidence of term born SGA neonates.
Design
A prospective cohort study was performed.
Patients
Thyroid function was assessed at 12, 24 and 36 weeks gestation in 1051 healthy Caucasian women who delivered at ≥37 weeks gestation.
Measurements
One-way anova was used to compare mean TSH and FT4 levels between women with SGA neonates and controls. Multiple logistic regression analysis was performed to adjust for known risk factors of SGA.
Results
Seventy (6·7%) SGA neonates were identified and they were significantly more often born to women with a TSH ≥ 97·5th at first and third trimester. Multiple logistic regression analysis showed that smoking (OR: 4·4, 95% CI: 2·49–7·64), pre-eclampsia (OR: 2·8, 95% CI: 1·19–6·78) and TSH ≥ 97·5th percentile (OR 3·3, 95% CI 1·39–7·53) were significantly related to SGA. Maternal FT4 levels and TPO-Ab status were not associated with SGA offspring.
Conclusions
Our data show that TSH levels in the upper range of the reference interval at different trimesters (3·0–3·29 mIU/l) are independently related to an increased risk of delivering SGA neonates at term.
Original languageEnglish
Pages (from-to)254–259
JournalClinical Endocrinology
Volume82
Issue number2
DOIs
Publication statusPublished - 2015

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Gestational Age
Mothers
Newborn Infant
Logistic Models
Perinatal Mortality
Premature Birth
Incidence

Cite this

Monen, L., Kuppens, S. M., Hasaart, T. H., Oosterbaan, H. P., Oei, S. G., Wijnen, H., ... Pop, V. J. M. (2015). Maternal thyrotropin is independently related to Small for Gestational Age neonates at term. Clinical Endocrinology, 82(2), 254–259. https://doi.org/10.1111/cen.12578
Monen, L. ; Kuppens, S.M. ; Hasaart, T.H. ; Oosterbaan, H.P. ; Oei, S.G. ; Wijnen, H. ; Hutton, E.K. ; Vader, H.L. ; Pop, V.J.M. / Maternal thyrotropin is independently related to Small for Gestational Age neonates at term. In: Clinical Endocrinology. 2015 ; Vol. 82, No. 2. pp. 254–259.
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title = "Maternal thyrotropin is independently related to Small for Gestational Age neonates at term",
abstract = "ObjectiveSmall for gestational age (SGA) newborns constitute still a major cause of perinatal morbidity and mortality. Overt thyroid disease is a known cause of preterm birth and low birthweight but in its untreated condition it is rare today. In this study, we investigated the possible relation between maternal thyroid function assessed in euthyroid women at each trimester and the incidence of term born SGA neonates.DesignA prospective cohort study was performed.PatientsThyroid function was assessed at 12, 24 and 36 weeks gestation in 1051 healthy Caucasian women who delivered at ≥37 weeks gestation.MeasurementsOne-way anova was used to compare mean TSH and FT4 levels between women with SGA neonates and controls. Multiple logistic regression analysis was performed to adjust for known risk factors of SGA.ResultsSeventy (6·7{\%}) SGA neonates were identified and they were significantly more often born to women with a TSH ≥ 97·5th at first and third trimester. Multiple logistic regression analysis showed that smoking (OR: 4·4, 95{\%} CI: 2·49–7·64), pre-eclampsia (OR: 2·8, 95{\%} CI: 1·19–6·78) and TSH ≥ 97·5th percentile (OR 3·3, 95{\%} CI 1·39–7·53) were significantly related to SGA. Maternal FT4 levels and TPO-Ab status were not associated with SGA offspring.ConclusionsOur data show that TSH levels in the upper range of the reference interval at different trimesters (3·0–3·29 mIU/l) are independently related to an increased risk of delivering SGA neonates at term.",
author = "L. Monen and S.M. Kuppens and T.H. Hasaart and H.P. Oosterbaan and S.G. Oei and H. Wijnen and E.K. Hutton and H.L. Vader and V.J.M. Pop",
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Monen, L, Kuppens, SM, Hasaart, TH, Oosterbaan, HP, Oei, SG, Wijnen, H, Hutton, EK, Vader, HL & Pop, VJM 2015, 'Maternal thyrotropin is independently related to Small for Gestational Age neonates at term', Clinical Endocrinology, vol. 82, no. 2, pp. 254–259. https://doi.org/10.1111/cen.12578

Maternal thyrotropin is independently related to Small for Gestational Age neonates at term. / Monen, L.; Kuppens, S.M.; Hasaart, T.H.; Oosterbaan, H.P.; Oei, S.G.; Wijnen, H.; Hutton, E.K.; Vader, H.L.; Pop, V.J.M.

In: Clinical Endocrinology, Vol. 82, No. 2, 2015, p. 254–259.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Maternal thyrotropin is independently related to Small for Gestational Age neonates at term

AU - Monen, L.

AU - Kuppens, S.M.

AU - Hasaart, T.H.

AU - Oosterbaan, H.P.

AU - Oei, S.G.

AU - Wijnen, H.

AU - Hutton, E.K.

AU - Vader, H.L.

AU - Pop, V.J.M.

PY - 2015

Y1 - 2015

N2 - ObjectiveSmall for gestational age (SGA) newborns constitute still a major cause of perinatal morbidity and mortality. Overt thyroid disease is a known cause of preterm birth and low birthweight but in its untreated condition it is rare today. In this study, we investigated the possible relation between maternal thyroid function assessed in euthyroid women at each trimester and the incidence of term born SGA neonates.DesignA prospective cohort study was performed.PatientsThyroid function was assessed at 12, 24 and 36 weeks gestation in 1051 healthy Caucasian women who delivered at ≥37 weeks gestation.MeasurementsOne-way anova was used to compare mean TSH and FT4 levels between women with SGA neonates and controls. Multiple logistic regression analysis was performed to adjust for known risk factors of SGA.ResultsSeventy (6·7%) SGA neonates were identified and they were significantly more often born to women with a TSH ≥ 97·5th at first and third trimester. Multiple logistic regression analysis showed that smoking (OR: 4·4, 95% CI: 2·49–7·64), pre-eclampsia (OR: 2·8, 95% CI: 1·19–6·78) and TSH ≥ 97·5th percentile (OR 3·3, 95% CI 1·39–7·53) were significantly related to SGA. Maternal FT4 levels and TPO-Ab status were not associated with SGA offspring.ConclusionsOur data show that TSH levels in the upper range of the reference interval at different trimesters (3·0–3·29 mIU/l) are independently related to an increased risk of delivering SGA neonates at term.

AB - ObjectiveSmall for gestational age (SGA) newborns constitute still a major cause of perinatal morbidity and mortality. Overt thyroid disease is a known cause of preterm birth and low birthweight but in its untreated condition it is rare today. In this study, we investigated the possible relation between maternal thyroid function assessed in euthyroid women at each trimester and the incidence of term born SGA neonates.DesignA prospective cohort study was performed.PatientsThyroid function was assessed at 12, 24 and 36 weeks gestation in 1051 healthy Caucasian women who delivered at ≥37 weeks gestation.MeasurementsOne-way anova was used to compare mean TSH and FT4 levels between women with SGA neonates and controls. Multiple logistic regression analysis was performed to adjust for known risk factors of SGA.ResultsSeventy (6·7%) SGA neonates were identified and they were significantly more often born to women with a TSH ≥ 97·5th at first and third trimester. Multiple logistic regression analysis showed that smoking (OR: 4·4, 95% CI: 2·49–7·64), pre-eclampsia (OR: 2·8, 95% CI: 1·19–6·78) and TSH ≥ 97·5th percentile (OR 3·3, 95% CI 1·39–7·53) were significantly related to SGA. Maternal FT4 levels and TPO-Ab status were not associated with SGA offspring.ConclusionsOur data show that TSH levels in the upper range of the reference interval at different trimesters (3·0–3·29 mIU/l) are independently related to an increased risk of delivering SGA neonates at term.

U2 - 10.1111/cen.12578

DO - 10.1111/cen.12578

M3 - Article

VL - 82

SP - 254

EP - 259

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 2

ER -

Monen L, Kuppens SM, Hasaart TH, Oosterbaan HP, Oei SG, Wijnen H et al. Maternal thyrotropin is independently related to Small for Gestational Age neonates at term. Clinical Endocrinology. 2015;82(2):254–259. https://doi.org/10.1111/cen.12578