Meta-analysis of exome array data identifies six novel genetic loci for lung function.

Ruifang Li

Research output: Contribution to journalArticleScientificpeer-review


Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV 1), forced vital capacity (FVC) and the ratio of FEV 1 to FVC (FEV 1/FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 individuals of European ancestry from 23 studies, and 7,721 individuals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent individuals. Results: We identified significant (P
Original languageUndefined/Unknown
JournalWellcome open research
Publication statusPublished - 12 Jan 2018
Externally publishedYes

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