Metabolomics profiling of Type D Personality traits

Nina Kupper, Ruifang Li, Mariska Bot, Alexander Kurilshikov, Gonneke Willemsen, Marleen J. van Greevenbroek, Miranda Schram, Coen Stehouwer, Jingyuan Fu, Alexandra Zhernakova, Brenda W. Penninx, Eco de Geus, Dorret Boomsma

Research output: Contribution to journalMeeting AbstractOther research output


Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an
increased risk of cardiometabolic diseases. Here, over 230 metabolites or metabolite ratios, predominantly lipids, were
investigated for their associations to the Type D personality traits.

Four Dutch cohorts were included, together comprising 10,834 individuals. The Type D personality traits (i.e., NA and SI)
were measured by either standard DS14 questionnaire (three cohorts) or ASEBA-based proxy (one cohort). A proton nuclear magnetic resonance metabolomics platform provided 149 absolute measures and 81 derived ratios. For all metabolite measures and ratios, linear regression analyses were performed within cohort, followed by random-effects meta-analyses. A per-measure FDR q-value of

SI was significantly associated with the ratio of omega-3 fatty acids to total fatty acids (FAw3.FA%) and free cholesterol to
total lipids ratio in very small VLDL (XS.VLDL.FC%). No significant associations were observed between metabolites and NA
or Type D. NA did show suggestive replication (p-value<.05) of the previously reported association with depression for five out of 21 metabolites measured on the same metabolomics platform, namely triglycerides in HDL (HDL.TG), serum total triglycerides (serum.TG), VLDL cholesterol (VLDL.C), mean diameter for VLDL particles (VLDL.D) and VLDL triglycerides (VLDL.TG).

The ratio of omega-3 fatty acids to total fatty acids was found to associate with social inhibition, which is suggestive of lower omega-3 fatty acid intake. Also, free cholesterol to total lipids ratio in very small VLDL was associated with SI. Our data did not show any metabolite biomarkers that link specifically to Type D. Further studies, including a broader spectrum of metabolites, are warranted to investigate Type D associated biomarkers beyond lipid metabolism
Original languageEnglish
Article number1476
Pages (from-to)A111-A111
JournalPsychosomatic Medicine
Issue number5
Publication statusPublished - 2022


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