Metabolomics profiling of Type D personality traits

Ruifang Li-Gao; Mariska Bot; Alexander Kurilshikov; Gonneke Willemsen; Marleen M J van Greevenbroek; Miranda M T Schram; Coen D A Stehouwer; Jingyuan Fu; Alexandra Zhernakova; Brenda W J H Penninx; Eco J C De Geus; Dorret I Boomsma; Nina Kupper

doi:10.1016/j.jpsychores.2024.111994

Metabolomics profiling of Type D personality traits

Ruifang Li-Gao, Mariska Bot, Alexander Kurilshikov, Gonneke Willemsen, Marleen M J van Greevenbroek, Miranda M T Schram, Coen D A Stehouwer, Jingyuan Fu, Alexandra Zhernakova, Brenda W J H Penninx, Eco J C De Geus, Dorret I Boomsma, Nina Kupper

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

OBJECTIVE: Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiometabolic diseases. Here, we examined the association of Type D traits with 230 (predominantly) lipid metabolites and metabolite ratios.

METHODS: Four Dutch cohorts were included, comprising 10,834 individuals. Type D personality traits were measured by self-report questionnaires. A proton nuclear magnetic resonance (NMR) metabolomics platform provided 149 absolute measures (98 belonging to lipoprotein subclasses) and 81 derived ratios. For all, linear regression analyses were performed within each cohort, followed by random-effects meta-analyses. A per-measure FDR q-value<0.05 was set as a study-wise significant association.

RESULTS: SI was significantly associated with a lower omega-3 fatty acids to total fatty acids (FAw3.FA%) ratio, and a lower free cholesterol to total lipids ratio in very small VLDL (XS.VLDL.FC%). FAw3.FA% was also associated to NA (no study-wise significance though). NA showed a suggestive replication (p-value<.05) of the previous reported associations with depression for 5 out of 18 metabolites from the same metabolomics platform: triglycerides in HDL, serum total triglycerides, VLDL cholesterol, mean diameter for VLDL particles and VLDL triglycerides.

CONCLUSIONS: In this large meta-analysis, SI was associated with omega-3 fatty acids to total fatty acids ratio, which is suggestive of lower omega-3 fatty acid intake. Only some metabolite biomarkers showed tentative links to Type D and NA. In sum, it seems that there are no major alterations in lipid metabolism associated with Type D traits.

Original language	English
Pages (from-to)	111994
Journal	Journal of Psychosomatic Research
Volume	188
DOIs	https://doi.org/10.1016/j.jpsychores.2024.111994
Publication status	E-pub ahead of print - 19 Nov 2024

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Li-Gao, R., Bot, M., Kurilshikov, A., Willemsen, G., van Greevenbroek, M. M. J., Schram, M. M. T., Stehouwer, C. D. A., Fu, J., Zhernakova, A., Penninx, B. W. J. H., De Geus, E. J. C., Boomsma, D. I., & Kupper, N. (2024). Metabolomics profiling of Type D personality traits. Journal of Psychosomatic Research, 188, 111994. Advance online publication. https://doi.org/10.1016/j.jpsychores.2024.111994

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title = "Metabolomics profiling of Type D personality traits",

abstract = "OBJECTIVE: Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiometabolic diseases. Here, we examined the association of Type D traits with 230 (predominantly) lipid metabolites and metabolite ratios.METHODS: Four Dutch cohorts were included, comprising 10,834 individuals. Type D personality traits were measured by self-report questionnaires. A proton nuclear magnetic resonance (NMR) metabolomics platform provided 149 absolute measures (98 belonging to lipoprotein subclasses) and 81 derived ratios. For all, linear regression analyses were performed within each cohort, followed by random-effects meta-analyses. A per-measure FDR q-value<0.05 was set as a study-wise significant association.RESULTS: SI was significantly associated with a lower omega-3 fatty acids to total fatty acids (FAw3.FA%) ratio, and a lower free cholesterol to total lipids ratio in very small VLDL (XS.VLDL.FC%). FAw3.FA% was also associated to NA (no study-wise significance though). NA showed a suggestive replication (p-value<.05) of the previous reported associations with depression for 5 out of 18 metabolites from the same metabolomics platform: triglycerides in HDL, serum total triglycerides, VLDL cholesterol, mean diameter for VLDL particles and VLDL triglycerides.CONCLUSIONS: In this large meta-analysis, SI was associated with omega-3 fatty acids to total fatty acids ratio, which is suggestive of lower omega-3 fatty acid intake. Only some metabolite biomarkers showed tentative links to Type D and NA. In sum, it seems that there are no major alterations in lipid metabolism associated with Type D traits.",

author = "Ruifang Li-Gao and Mariska Bot and Alexander Kurilshikov and Gonneke Willemsen and {van Greevenbroek}, {Marleen M J} and Schram, {Miranda M T} and Stehouwer, {Coen D A} and Jingyuan Fu and Alexandra Zhernakova and Penninx, {Brenda W J H} and {De Geus}, {Eco J C} and Boomsma, {Dorret I} and Nina Kupper",

year = "2024",

month = nov,

day = "19",

doi = "10.1016/j.jpsychores.2024.111994",

language = "English",

volume = "188",

pages = "111994",

journal = "Journal of Psychosomatic Research",

issn = "0022-3999",

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T1 - Metabolomics profiling of Type D personality traits

AU - Li-Gao, Ruifang

AU - Bot, Mariska

AU - Kurilshikov, Alexander

AU - Willemsen, Gonneke

AU - van Greevenbroek, Marleen M J

AU - Schram, Miranda M T

AU - Stehouwer, Coen D A

AU - Fu, Jingyuan

AU - Zhernakova, Alexandra

AU - Penninx, Brenda W J H

AU - De Geus, Eco J C

AU - Boomsma, Dorret I

AU - Kupper, Nina

PY - 2024/11/19

Y1 - 2024/11/19

N2 - OBJECTIVE: Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiometabolic diseases. Here, we examined the association of Type D traits with 230 (predominantly) lipid metabolites and metabolite ratios.METHODS: Four Dutch cohorts were included, comprising 10,834 individuals. Type D personality traits were measured by self-report questionnaires. A proton nuclear magnetic resonance (NMR) metabolomics platform provided 149 absolute measures (98 belonging to lipoprotein subclasses) and 81 derived ratios. For all, linear regression analyses were performed within each cohort, followed by random-effects meta-analyses. A per-measure FDR q-value<0.05 was set as a study-wise significant association.RESULTS: SI was significantly associated with a lower omega-3 fatty acids to total fatty acids (FAw3.FA%) ratio, and a lower free cholesterol to total lipids ratio in very small VLDL (XS.VLDL.FC%). FAw3.FA% was also associated to NA (no study-wise significance though). NA showed a suggestive replication (p-value<.05) of the previous reported associations with depression for 5 out of 18 metabolites from the same metabolomics platform: triglycerides in HDL, serum total triglycerides, VLDL cholesterol, mean diameter for VLDL particles and VLDL triglycerides.CONCLUSIONS: In this large meta-analysis, SI was associated with omega-3 fatty acids to total fatty acids ratio, which is suggestive of lower omega-3 fatty acid intake. Only some metabolite biomarkers showed tentative links to Type D and NA. In sum, it seems that there are no major alterations in lipid metabolism associated with Type D traits.

AB - OBJECTIVE: Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiometabolic diseases. Here, we examined the association of Type D traits with 230 (predominantly) lipid metabolites and metabolite ratios.METHODS: Four Dutch cohorts were included, comprising 10,834 individuals. Type D personality traits were measured by self-report questionnaires. A proton nuclear magnetic resonance (NMR) metabolomics platform provided 149 absolute measures (98 belonging to lipoprotein subclasses) and 81 derived ratios. For all, linear regression analyses were performed within each cohort, followed by random-effects meta-analyses. A per-measure FDR q-value<0.05 was set as a study-wise significant association.RESULTS: SI was significantly associated with a lower omega-3 fatty acids to total fatty acids (FAw3.FA%) ratio, and a lower free cholesterol to total lipids ratio in very small VLDL (XS.VLDL.FC%). FAw3.FA% was also associated to NA (no study-wise significance though). NA showed a suggestive replication (p-value<.05) of the previous reported associations with depression for 5 out of 18 metabolites from the same metabolomics platform: triglycerides in HDL, serum total triglycerides, VLDL cholesterol, mean diameter for VLDL particles and VLDL triglycerides.CONCLUSIONS: In this large meta-analysis, SI was associated with omega-3 fatty acids to total fatty acids ratio, which is suggestive of lower omega-3 fatty acid intake. Only some metabolite biomarkers showed tentative links to Type D and NA. In sum, it seems that there are no major alterations in lipid metabolism associated with Type D traits.

U2 - 10.1016/j.jpsychores.2024.111994

DO - 10.1016/j.jpsychores.2024.111994

M3 - Article

C2 - 39577138

SN - 0022-3999

VL - 188

SP - 111994

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

ER -

Metabolomics profiling of Type D personality traits

Abstract

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