Neurocognitive dysfunctioning and the impact of comorbid depression and anxiety in patients with somatic symptom and related disorders

A cross-sectional clinical study

L. De Vroege, Anique Timmermans, W.J. Kop, C.M. van der Feltz-Cornelis

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background
The prevalence and severity of neurocognitive dysfunctioning of patients with somatic symptom and related disorders (SSRD) is unknown. Furthermore, the influence of comorbid depression and anxiety has not been evaluated. This study examines neurocognitive dysfunctioning of patients with SSRD and explores if comorbid depression and anxiety is associated with specific neurocognitive dysfunctioning.
Methods
Cross-sectional study with consecutive patients suffering from SSRD visiting an outpatient specialty mental health care Centre of Excellence for SSRD. Extensive neuropsychological assessment and assessment of depression and anxiety symptom levels using the Patient-Health-Questionnaire-9 and General Anxiety Disorder questionnaire-7 were performed at intake. Multivariate analysis was performed.
Results
The study sample consisted of 201 SSRD patients, with a mean age of 43 years (Standard deviation = 13) years; 37.8% were male. Neurocognitive dysfunction in the domains information processing speed, sustained and divided attention, working memory, verbal and visual memory were reported, compared with normative data. Comorbid depression and anxiety occurred frequently within the sample (75.1% and 65.7%, respectively). Neurocognitive dysfunctioning was worse in patients suffering from comorbid depression [multivariate F (7,161) = 2.839, p = 0.008] but not in patients with comorbid anxiety.
Conclusions
Poor neurocognitive performance of patients with SSRD is common and worsens in case of comorbid depression. This may explain treatment dropout of patients with SSRD from neurocognitive behavioral therapy. Research on novel interventions is needed targeting neurocognitive functioning of patients with SSRD, particularly those with comorbid depression.
Original languageEnglish
Pages (from-to)1803-1813
JournalPsychological Medicine
Volume48
Issue number11
DOIs
Publication statusPublished - 2018

Fingerprint

Cross-Sectional Studies
Depression
Medically Unexplained Symptoms
Patient Dropouts
Short-Term Memory
Mental Health
Outpatients
Multivariate Analysis
Delivery of Health Care

Keywords

  • ADULTS
  • ATTENTION
  • COGNITIVE DYSFUNCTION
  • CONVERSION DISORDER
  • EXECUTIVE FUNCTION
  • METAANALYSIS
  • POSTTRAUMATIC-STRESS-DISORDER
  • SEVERITY
  • SOMATOFORM DISORDERS
  • WORKING-MEMORY
  • anxiety
  • depression
  • neurocognitive functioning
  • neuropsychology
  • somatic symptom and related disorders

Cite this

@article{c06ed4ae6ab44a3ea6fcd8a45af2ea94,
title = "Neurocognitive dysfunctioning and the impact of comorbid depression and anxiety in patients with somatic symptom and related disorders: A cross-sectional clinical study",
abstract = "BackgroundThe prevalence and severity of neurocognitive dysfunctioning of patients with somatic symptom and related disorders (SSRD) is unknown. Furthermore, the influence of comorbid depression and anxiety has not been evaluated. This study examines neurocognitive dysfunctioning of patients with SSRD and explores if comorbid depression and anxiety is associated with specific neurocognitive dysfunctioning.MethodsCross-sectional study with consecutive patients suffering from SSRD visiting an outpatient specialty mental health care Centre of Excellence for SSRD. Extensive neuropsychological assessment and assessment of depression and anxiety symptom levels using the Patient-Health-Questionnaire-9 and General Anxiety Disorder questionnaire-7 were performed at intake. Multivariate analysis was performed.ResultsThe study sample consisted of 201 SSRD patients, with a mean age of 43 years (Standard deviation = 13) years; 37.8{\%} were male. Neurocognitive dysfunction in the domains information processing speed, sustained and divided attention, working memory, verbal and visual memory were reported, compared with normative data. Comorbid depression and anxiety occurred frequently within the sample (75.1{\%} and 65.7{\%}, respectively). Neurocognitive dysfunctioning was worse in patients suffering from comorbid depression [multivariate F (7,161) = 2.839, p = 0.008] but not in patients with comorbid anxiety.ConclusionsPoor neurocognitive performance of patients with SSRD is common and worsens in case of comorbid depression. This may explain treatment dropout of patients with SSRD from neurocognitive behavioral therapy. Research on novel interventions is needed targeting neurocognitive functioning of patients with SSRD, particularly those with comorbid depression.",
keywords = "ADULTS, ATTENTION, COGNITIVE DYSFUNCTION, CONVERSION DISORDER, EXECUTIVE FUNCTION, METAANALYSIS, POSTTRAUMATIC-STRESS-DISORDER, SEVERITY, SOMATOFORM DISORDERS, WORKING-MEMORY, anxiety, depression, neurocognitive functioning, neuropsychology, somatic symptom and related disorders",
author = "{De Vroege}, L. and Anique Timmermans and W.J. Kop and {van der Feltz-Cornelis}, C.M.",
year = "2018",
doi = "10.1017/S0033291717003300",
language = "English",
volume = "48",
pages = "1803--1813",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "CAMBRIDGE UNIV PRESS",
number = "11",

}

Neurocognitive dysfunctioning and the impact of comorbid depression and anxiety in patients with somatic symptom and related disorders : A cross-sectional clinical study. / De Vroege, L.; Timmermans, Anique; Kop, W.J.; van der Feltz-Cornelis, C.M.

In: Psychological Medicine, Vol. 48, No. 11, 2018, p. 1803-1813.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Neurocognitive dysfunctioning and the impact of comorbid depression and anxiety in patients with somatic symptom and related disorders

T2 - A cross-sectional clinical study

AU - De Vroege, L.

AU - Timmermans, Anique

AU - Kop, W.J.

AU - van der Feltz-Cornelis, C.M.

PY - 2018

Y1 - 2018

N2 - BackgroundThe prevalence and severity of neurocognitive dysfunctioning of patients with somatic symptom and related disorders (SSRD) is unknown. Furthermore, the influence of comorbid depression and anxiety has not been evaluated. This study examines neurocognitive dysfunctioning of patients with SSRD and explores if comorbid depression and anxiety is associated with specific neurocognitive dysfunctioning.MethodsCross-sectional study with consecutive patients suffering from SSRD visiting an outpatient specialty mental health care Centre of Excellence for SSRD. Extensive neuropsychological assessment and assessment of depression and anxiety symptom levels using the Patient-Health-Questionnaire-9 and General Anxiety Disorder questionnaire-7 were performed at intake. Multivariate analysis was performed.ResultsThe study sample consisted of 201 SSRD patients, with a mean age of 43 years (Standard deviation = 13) years; 37.8% were male. Neurocognitive dysfunction in the domains information processing speed, sustained and divided attention, working memory, verbal and visual memory were reported, compared with normative data. Comorbid depression and anxiety occurred frequently within the sample (75.1% and 65.7%, respectively). Neurocognitive dysfunctioning was worse in patients suffering from comorbid depression [multivariate F (7,161) = 2.839, p = 0.008] but not in patients with comorbid anxiety.ConclusionsPoor neurocognitive performance of patients with SSRD is common and worsens in case of comorbid depression. This may explain treatment dropout of patients with SSRD from neurocognitive behavioral therapy. Research on novel interventions is needed targeting neurocognitive functioning of patients with SSRD, particularly those with comorbid depression.

AB - BackgroundThe prevalence and severity of neurocognitive dysfunctioning of patients with somatic symptom and related disorders (SSRD) is unknown. Furthermore, the influence of comorbid depression and anxiety has not been evaluated. This study examines neurocognitive dysfunctioning of patients with SSRD and explores if comorbid depression and anxiety is associated with specific neurocognitive dysfunctioning.MethodsCross-sectional study with consecutive patients suffering from SSRD visiting an outpatient specialty mental health care Centre of Excellence for SSRD. Extensive neuropsychological assessment and assessment of depression and anxiety symptom levels using the Patient-Health-Questionnaire-9 and General Anxiety Disorder questionnaire-7 were performed at intake. Multivariate analysis was performed.ResultsThe study sample consisted of 201 SSRD patients, with a mean age of 43 years (Standard deviation = 13) years; 37.8% were male. Neurocognitive dysfunction in the domains information processing speed, sustained and divided attention, working memory, verbal and visual memory were reported, compared with normative data. Comorbid depression and anxiety occurred frequently within the sample (75.1% and 65.7%, respectively). Neurocognitive dysfunctioning was worse in patients suffering from comorbid depression [multivariate F (7,161) = 2.839, p = 0.008] but not in patients with comorbid anxiety.ConclusionsPoor neurocognitive performance of patients with SSRD is common and worsens in case of comorbid depression. This may explain treatment dropout of patients with SSRD from neurocognitive behavioral therapy. Research on novel interventions is needed targeting neurocognitive functioning of patients with SSRD, particularly those with comorbid depression.

KW - ADULTS

KW - ATTENTION

KW - COGNITIVE DYSFUNCTION

KW - CONVERSION DISORDER

KW - EXECUTIVE FUNCTION

KW - METAANALYSIS

KW - POSTTRAUMATIC-STRESS-DISORDER

KW - SEVERITY

KW - SOMATOFORM DISORDERS

KW - WORKING-MEMORY

KW - anxiety

KW - depression

KW - neurocognitive functioning

KW - neuropsychology

KW - somatic symptom and related disorders

U2 - 10.1017/S0033291717003300

DO - 10.1017/S0033291717003300

M3 - Article

VL - 48

SP - 1803

EP - 1813

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 11

ER -