Optimistic, realistic, and pessimistic illness perceptions; quality of life; and survival among 2457 cancer survivors

The population‐based PROFILES registry

B.H. de Rooij, M.S.Y. Thong, J. van Roij, C.S. Bonhof, O. Husson, N.P.M. Ezendam

Research output: Contribution to journalArticleScientificpeer-review

3 Downloads (Pure)

Abstract

Background 
Threatening illness perceptions (IPs) have been associated with poorer health outcomes. However, to the authors' knowledge, it remains unclear whether threatening IPs that are consistent with disease severity are equally harmful. The aim of the current study was to: 1) identify subgroups of cancer survivors based on IP and prognosis; and 2) assess the health‐related quality of life (HRQOL) and survival associated with these subgroups. 

Methods 
The authors used survey data from the population‐based Patient Reported Outcomes Following Initial treatment and Long term Evaluation of Survivorship (PROFILES) registry, which were collected between 2008 and 2015 and included 2457 cancer survivors who were <5 years after their cancer diagnosis (colon, rectal, prostate, endometrial, or ovarian cancer or non‐Hodgkin lymphoma). Clinical and survival data were collected through the Netherlands Cancer Registry. Subgroups were defined by IP (Brief Illness Perception Questionnaire) and prognosis (conditional 5‐year relative survival) into survivors with 1) an IP consistent with prognosis (“realistic”); 2) a less threatening IP than expected based on prognosis (“optimistic”); and 3) a more threatening IP than expected based on prognosis (“pessimistic”). 

Results 
Compared with survivors with a realistic IP (1230 survivors), those with an optimistic IP (582 survivors) were found to have a higher HRQOL (P < .01 on all European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 [EORTC QLQ‐C30] scales) and a lower all‐cause mortality (hazard ratio, 0.72; P < .01), whereas those with a pessimistic IP (645 survivors) had a lower HRQOL (P < .01 on all scales) and a higher all‐cause mortality (hazard ratio, 1.52; P < .01). 

Conclusions 
An optimistic IP is associated with better HRQOL and survival, even if it may appear to be unrealistic with respect to cancer survivors' prognosis. Survivors with a pessimistic IP appear to have the worst outcomes. Therefore, efforts are needed to provide better support to patients with pessimistic IPs to improve their outcomes. Cancer 2018;000:000‐000
Original languageEnglish
Pages (from-to)3609-3617
JournalCancer: A journal of the American Cancer Society
Volume124
Issue number17
DOIs
Publication statusPublished - 2018

Fingerprint

Survivors
Survival Rate
Neoplasms
Endometrial Neoplasms
Netherlands
Ovarian Neoplasms
Non-Hodgkin's Lymphoma
Organizations
Surveys and Questionnaires

Keywords

  • BREAST-CANCER
  • COLORECTAL-CANCER
  • FOLLOW-UP
  • MORTALITY
  • PATIENT-REPORTED OUTCOMES
  • PROSTATE-CANCER
  • QUESTIONNAIRE
  • RADIOTHERAPY
  • REPRESENTATIONS
  • SELF-RATED HEALTH
  • cancer survivors
  • health-related quality of life (HRQOL)
  • illness perceptions (IPs)
  • prognosis
  • survival

Cite this

@article{c33ca7c9a77f47f3a8fd9d597f30d163,
title = "Optimistic, realistic, and pessimistic illness perceptions; quality of life; and survival among 2457 cancer survivors: The population‐based PROFILES registry",
abstract = "Background Threatening illness perceptions (IPs) have been associated with poorer health outcomes. However, to the authors' knowledge, it remains unclear whether threatening IPs that are consistent with disease severity are equally harmful. The aim of the current study was to: 1) identify subgroups of cancer survivors based on IP and prognosis; and 2) assess the health‐related quality of life (HRQOL) and survival associated with these subgroups. Methods The authors used survey data from the population‐based Patient Reported Outcomes Following Initial treatment and Long term Evaluation of Survivorship (PROFILES) registry, which were collected between 2008 and 2015 and included 2457 cancer survivors who were <5 years after their cancer diagnosis (colon, rectal, prostate, endometrial, or ovarian cancer or non‐Hodgkin lymphoma). Clinical and survival data were collected through the Netherlands Cancer Registry. Subgroups were defined by IP (Brief Illness Perception Questionnaire) and prognosis (conditional 5‐year relative survival) into survivors with 1) an IP consistent with prognosis (“realistic”); 2) a less threatening IP than expected based on prognosis (“optimistic”); and 3) a more threatening IP than expected based on prognosis (“pessimistic”). Results Compared with survivors with a realistic IP (1230 survivors), those with an optimistic IP (582 survivors) were found to have a higher HRQOL (P < .01 on all European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 [EORTC QLQ‐C30] scales) and a lower all‐cause mortality (hazard ratio, 0.72; P < .01), whereas those with a pessimistic IP (645 survivors) had a lower HRQOL (P < .01 on all scales) and a higher all‐cause mortality (hazard ratio, 1.52; P < .01). Conclusions An optimistic IP is associated with better HRQOL and survival, even if it may appear to be unrealistic with respect to cancer survivors' prognosis. Survivors with a pessimistic IP appear to have the worst outcomes. Therefore, efforts are needed to provide better support to patients with pessimistic IPs to improve their outcomes. Cancer 2018;000:000‐000",
keywords = "BREAST-CANCER, COLORECTAL-CANCER, FOLLOW-UP, MORTALITY, PATIENT-REPORTED OUTCOMES, PROSTATE-CANCER, QUESTIONNAIRE, RADIOTHERAPY, REPRESENTATIONS, SELF-RATED HEALTH, cancer survivors, health-related quality of life (HRQOL), illness perceptions (IPs), prognosis, survival",
author = "{de Rooij}, B.H. and M.S.Y. Thong and {van Roij}, J. and C.S. Bonhof and O. Husson and N.P.M. Ezendam",
year = "2018",
doi = "10.1002/cncr.31634",
language = "English",
volume = "124",
pages = "3609--3617",
journal = "Cancer: A journal of the American Cancer Society",
issn = "0008-543X",
publisher = "Wiley",
number = "17",

}

Optimistic, realistic, and pessimistic illness perceptions; quality of life; and survival among 2457 cancer survivors : The population‐based PROFILES registry. / de Rooij, B.H.; Thong, M.S.Y.; van Roij, J.; Bonhof, C.S.; Husson, O.; Ezendam, N.P.M.

In: Cancer: A journal of the American Cancer Society, Vol. 124, No. 17, 2018, p. 3609-3617.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Optimistic, realistic, and pessimistic illness perceptions; quality of life; and survival among 2457 cancer survivors

T2 - The population‐based PROFILES registry

AU - de Rooij, B.H.

AU - Thong, M.S.Y.

AU - van Roij, J.

AU - Bonhof, C.S.

AU - Husson, O.

AU - Ezendam, N.P.M.

PY - 2018

Y1 - 2018

N2 - Background Threatening illness perceptions (IPs) have been associated with poorer health outcomes. However, to the authors' knowledge, it remains unclear whether threatening IPs that are consistent with disease severity are equally harmful. The aim of the current study was to: 1) identify subgroups of cancer survivors based on IP and prognosis; and 2) assess the health‐related quality of life (HRQOL) and survival associated with these subgroups. Methods The authors used survey data from the population‐based Patient Reported Outcomes Following Initial treatment and Long term Evaluation of Survivorship (PROFILES) registry, which were collected between 2008 and 2015 and included 2457 cancer survivors who were <5 years after their cancer diagnosis (colon, rectal, prostate, endometrial, or ovarian cancer or non‐Hodgkin lymphoma). Clinical and survival data were collected through the Netherlands Cancer Registry. Subgroups were defined by IP (Brief Illness Perception Questionnaire) and prognosis (conditional 5‐year relative survival) into survivors with 1) an IP consistent with prognosis (“realistic”); 2) a less threatening IP than expected based on prognosis (“optimistic”); and 3) a more threatening IP than expected based on prognosis (“pessimistic”). Results Compared with survivors with a realistic IP (1230 survivors), those with an optimistic IP (582 survivors) were found to have a higher HRQOL (P < .01 on all European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 [EORTC QLQ‐C30] scales) and a lower all‐cause mortality (hazard ratio, 0.72; P < .01), whereas those with a pessimistic IP (645 survivors) had a lower HRQOL (P < .01 on all scales) and a higher all‐cause mortality (hazard ratio, 1.52; P < .01). Conclusions An optimistic IP is associated with better HRQOL and survival, even if it may appear to be unrealistic with respect to cancer survivors' prognosis. Survivors with a pessimistic IP appear to have the worst outcomes. Therefore, efforts are needed to provide better support to patients with pessimistic IPs to improve their outcomes. Cancer 2018;000:000‐000

AB - Background Threatening illness perceptions (IPs) have been associated with poorer health outcomes. However, to the authors' knowledge, it remains unclear whether threatening IPs that are consistent with disease severity are equally harmful. The aim of the current study was to: 1) identify subgroups of cancer survivors based on IP and prognosis; and 2) assess the health‐related quality of life (HRQOL) and survival associated with these subgroups. Methods The authors used survey data from the population‐based Patient Reported Outcomes Following Initial treatment and Long term Evaluation of Survivorship (PROFILES) registry, which were collected between 2008 and 2015 and included 2457 cancer survivors who were <5 years after their cancer diagnosis (colon, rectal, prostate, endometrial, or ovarian cancer or non‐Hodgkin lymphoma). Clinical and survival data were collected through the Netherlands Cancer Registry. Subgroups were defined by IP (Brief Illness Perception Questionnaire) and prognosis (conditional 5‐year relative survival) into survivors with 1) an IP consistent with prognosis (“realistic”); 2) a less threatening IP than expected based on prognosis (“optimistic”); and 3) a more threatening IP than expected based on prognosis (“pessimistic”). Results Compared with survivors with a realistic IP (1230 survivors), those with an optimistic IP (582 survivors) were found to have a higher HRQOL (P < .01 on all European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 [EORTC QLQ‐C30] scales) and a lower all‐cause mortality (hazard ratio, 0.72; P < .01), whereas those with a pessimistic IP (645 survivors) had a lower HRQOL (P < .01 on all scales) and a higher all‐cause mortality (hazard ratio, 1.52; P < .01). Conclusions An optimistic IP is associated with better HRQOL and survival, even if it may appear to be unrealistic with respect to cancer survivors' prognosis. Survivors with a pessimistic IP appear to have the worst outcomes. Therefore, efforts are needed to provide better support to patients with pessimistic IPs to improve their outcomes. Cancer 2018;000:000‐000

KW - BREAST-CANCER

KW - COLORECTAL-CANCER

KW - FOLLOW-UP

KW - MORTALITY

KW - PATIENT-REPORTED OUTCOMES

KW - PROSTATE-CANCER

KW - QUESTIONNAIRE

KW - RADIOTHERAPY

KW - REPRESENTATIONS

KW - SELF-RATED HEALTH

KW - cancer survivors

KW - health-related quality of life (HRQOL)

KW - illness perceptions (IPs)

KW - prognosis

KW - survival

U2 - 10.1002/cncr.31634

DO - 10.1002/cncr.31634

M3 - Article

VL - 124

SP - 3609

EP - 3617

JO - Cancer: A journal of the American Cancer Society

JF - Cancer: A journal of the American Cancer Society

SN - 0008-543X

IS - 17

ER -