Oxytocin receptor gene (OXTR) in relation to loneliness in adolescence

Eeske van Roekel, Maaike Verhagen, Rutger C. M. E. Engels, Luc Goossens, Ron H. J. Scholte

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background Recent research has shown that loneliness, a common problem in adolescence, may have a genetic basis. The evidence, though, was limited mostly to serotonin-related and dopamine-related genes. In the present study, we focused on the oxytocin receptor gene (OXTR).Methods Associations were examined in a longitudinal study spanning five annual waves (N=307). The relations between OXTR and loneliness were examined, as well as interactions between OXTR and sex, parental support, 5-HTTLPR genotype, and DRD2 genotype.Results Using Latent Growth Curve Modeling, the OXTR genotype was not directly related to loneliness. An OXTRxsex interaction was found. Girls showed a steeper decline in loneliness when they had an A allele compared with girls who were homozygous for the G allele. In addition, a gene-gene interaction or epistasis was observed. Both boys and girls who had at least one A1 allele for the DRD2 gene and also had the GG genotype for the OXTR gene showed stable levels of loneliness over time.Conclusion The present study is the first to show that the GG genotype for the OXTR gene is linked to the development of loneliness in adolescence and that this association is moderated by participants' sex and their genotype for a dopamine-related gene. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

Original languageEnglish
Pages (from-to)204-213
Number of pages10
JournalPSYCHIATRIC GENETICS
Volume23
Issue number5
DOIs
Publication statusPublished - Oct 2013
Externally publishedYes

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Oxytocin Receptors
Loneliness
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Keywords

  • adolescence
  • DRD2
  • gene-gene interactions
  • 5-HTTLPR
  • loneliness
  • OXTR
  • sex differences
  • SEROTONIN TRANSPORTER GENE
  • ENVIRONMENT INTERACTIONS
  • POLYMORPHISM
  • ASSOCIATION
  • HUMANS
  • ANKK1
  • NEUROBIOLOGY
  • EXPRESSION
  • ADJUSTMENT
  • DEPRESSION

Cite this

van Roekel, E., Verhagen, M., Engels, R. C. M. E., Goossens, L., & Scholte, R. H. J. (2013). Oxytocin receptor gene (OXTR) in relation to loneliness in adolescence. PSYCHIATRIC GENETICS, 23(5), 204-213. https://doi.org/10.1097/YPG.0b013e328363f631
van Roekel, Eeske ; Verhagen, Maaike ; Engels, Rutger C. M. E. ; Goossens, Luc ; Scholte, Ron H. J. / Oxytocin receptor gene (OXTR) in relation to loneliness in adolescence. In: PSYCHIATRIC GENETICS. 2013 ; Vol. 23, No. 5. pp. 204-213.
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abstract = "Background Recent research has shown that loneliness, a common problem in adolescence, may have a genetic basis. The evidence, though, was limited mostly to serotonin-related and dopamine-related genes. In the present study, we focused on the oxytocin receptor gene (OXTR).Methods Associations were examined in a longitudinal study spanning five annual waves (N=307). The relations between OXTR and loneliness were examined, as well as interactions between OXTR and sex, parental support, 5-HTTLPR genotype, and DRD2 genotype.Results Using Latent Growth Curve Modeling, the OXTR genotype was not directly related to loneliness. An OXTRxsex interaction was found. Girls showed a steeper decline in loneliness when they had an A allele compared with girls who were homozygous for the G allele. In addition, a gene-gene interaction or epistasis was observed. Both boys and girls who had at least one A1 allele for the DRD2 gene and also had the GG genotype for the OXTR gene showed stable levels of loneliness over time.Conclusion The present study is the first to show that the GG genotype for the OXTR gene is linked to the development of loneliness in adolescence and that this association is moderated by participants' sex and their genotype for a dopamine-related gene. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.",
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Oxytocin receptor gene (OXTR) in relation to loneliness in adolescence. / van Roekel, Eeske; Verhagen, Maaike; Engels, Rutger C. M. E.; Goossens, Luc; Scholte, Ron H. J.

In: PSYCHIATRIC GENETICS, Vol. 23, No. 5, 10.2013, p. 204-213.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Oxytocin receptor gene (OXTR) in relation to loneliness in adolescence

AU - van Roekel, Eeske

AU - Verhagen, Maaike

AU - Engels, Rutger C. M. E.

AU - Goossens, Luc

AU - Scholte, Ron H. J.

PY - 2013/10

Y1 - 2013/10

N2 - Background Recent research has shown that loneliness, a common problem in adolescence, may have a genetic basis. The evidence, though, was limited mostly to serotonin-related and dopamine-related genes. In the present study, we focused on the oxytocin receptor gene (OXTR).Methods Associations were examined in a longitudinal study spanning five annual waves (N=307). The relations between OXTR and loneliness were examined, as well as interactions between OXTR and sex, parental support, 5-HTTLPR genotype, and DRD2 genotype.Results Using Latent Growth Curve Modeling, the OXTR genotype was not directly related to loneliness. An OXTRxsex interaction was found. Girls showed a steeper decline in loneliness when they had an A allele compared with girls who were homozygous for the G allele. In addition, a gene-gene interaction or epistasis was observed. Both boys and girls who had at least one A1 allele for the DRD2 gene and also had the GG genotype for the OXTR gene showed stable levels of loneliness over time.Conclusion The present study is the first to show that the GG genotype for the OXTR gene is linked to the development of loneliness in adolescence and that this association is moderated by participants' sex and their genotype for a dopamine-related gene. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

AB - Background Recent research has shown that loneliness, a common problem in adolescence, may have a genetic basis. The evidence, though, was limited mostly to serotonin-related and dopamine-related genes. In the present study, we focused on the oxytocin receptor gene (OXTR).Methods Associations were examined in a longitudinal study spanning five annual waves (N=307). The relations between OXTR and loneliness were examined, as well as interactions between OXTR and sex, parental support, 5-HTTLPR genotype, and DRD2 genotype.Results Using Latent Growth Curve Modeling, the OXTR genotype was not directly related to loneliness. An OXTRxsex interaction was found. Girls showed a steeper decline in loneliness when they had an A allele compared with girls who were homozygous for the G allele. In addition, a gene-gene interaction or epistasis was observed. Both boys and girls who had at least one A1 allele for the DRD2 gene and also had the GG genotype for the OXTR gene showed stable levels of loneliness over time.Conclusion The present study is the first to show that the GG genotype for the OXTR gene is linked to the development of loneliness in adolescence and that this association is moderated by participants' sex and their genotype for a dopamine-related gene. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

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KW - ENVIRONMENT INTERACTIONS

KW - POLYMORPHISM

KW - ASSOCIATION

KW - HUMANS

KW - ANKK1

KW - NEUROBIOLOGY

KW - EXPRESSION

KW - ADJUSTMENT

KW - DEPRESSION

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M3 - Article

VL - 23

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EP - 213

JO - PSYCHIATRIC GENETICS

JF - PSYCHIATRIC GENETICS

SN - 0955-8829

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