Parental depressive and anxiety symptoms during pregnancy and attention problems in children

A cross-cohort consistency study

T. van Batenburg-Eddes, M.J. Brion, J. Henrichs, V.W. Jaddoe, A. Hofman, F.C. Verhulst, D.A. Lawlor, G. Davey Smith, H.W. Tiemeier

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background: 
Maternal depression and anxiety during pregnancy have been associated with offspring-attention deficit problems.
Aim: 
We explored possible intrauterine effects by comparing maternal and paternal symptoms during pregnancy, by investigating cross-cohort consistency, and by investigating whether parental symptoms in early childhood may explain any observed intrauterine effect.
Methods: 
This study was conducted in two cohorts (Generation R, n = 2,280 and ALSPAC, n = 3,442). Pregnant women and their partners completed questionnaires to assess symptoms of depression and anxiety. Child attention problems were measured in Generation R at age 3 with the Child Behavior Checklist, and in ALSPAC at age 4 with the Strengths and Difficulties Questionnaire.
Results: 
In both cohorts, antenatal maternal symptoms of depression (Generation R: OR 1.23, 95% CI 1.05–1.43; ALSPAC: OR 1.33, 95% CI 1.19–1.48) and anxiety (Generation R: OR 1.24, 95% CI 1.06–1.46; ALSPAC: OR 1.32, 95% CI 1.19–1.47) were associated with a higher risk of child attention problems. In ALSPAC, paternal depression was also associated with a higher risk of child attention problems (OR 1.11, 95% CI 1.00–1.24). After adjusting for maternal symptoms after giving birth, antenatal maternal depression and anxiety were no longer associated with child attention problems in Generation R. Moreover, there was little statistical evidence that antenatal maternal and paternal depression and anxiety had a substantially different effect on attention problems of the child.
Conclusions: 
The apparent intrauterine effect of maternal depression and anxiety on offspring-behavioural problems may be partly explained by residual confounding. There was little evidence of a difference between the strength of associations of maternal and paternal symptoms during pregnancy with offspring-attention problems. That maternal symptoms after childbirth were also associated with offspring-behavioural problems may indicate a contribution of genetic influences to the association.
Original languageEnglish
Pages (from-to)591-600
JournalJournal of Child Psychology and Psychiatry
Volume54
Issue number5
DOIs
Publication statusPublished - 2013

Fingerprint

Mothers
Depression
Child Behavior
Checklist

Cite this

van Batenburg-Eddes, T., Brion, M. J., Henrichs, J., Jaddoe, V. W., Hofman, A., Verhulst, F. C., ... Tiemeier, H. W. (2013). Parental depressive and anxiety symptoms during pregnancy and attention problems in children: A cross-cohort consistency study. Journal of Child Psychology and Psychiatry, 54(5), 591-600. https://doi.org/10.1111/jcpp.12023
van Batenburg-Eddes, T. ; Brion, M.J. ; Henrichs, J. ; Jaddoe, V.W. ; Hofman, A. ; Verhulst, F.C. ; Lawlor, D.A. ; Davey Smith, G. ; Tiemeier, H.W. / Parental depressive and anxiety symptoms during pregnancy and attention problems in children : A cross-cohort consistency study. In: Journal of Child Psychology and Psychiatry. 2013 ; Vol. 54, No. 5. pp. 591-600.
@article{eddd80d83bee47a7883a054b2e2166a5,
title = "Parental depressive and anxiety symptoms during pregnancy and attention problems in children: A cross-cohort consistency study",
abstract = "Background:  Maternal depression and anxiety during pregnancy have been associated with offspring-attention deficit problems.Aim:  We explored possible intrauterine effects by comparing maternal and paternal symptoms during pregnancy, by investigating cross-cohort consistency, and by investigating whether parental symptoms in early childhood may explain any observed intrauterine effect.Methods:  This study was conducted in two cohorts (Generation R, n = 2,280 and ALSPAC, n = 3,442). Pregnant women and their partners completed questionnaires to assess symptoms of depression and anxiety. Child attention problems were measured in Generation R at age 3 with the Child Behavior Checklist, and in ALSPAC at age 4 with the Strengths and Difficulties Questionnaire.Results:  In both cohorts, antenatal maternal symptoms of depression (Generation R: OR 1.23, 95{\%} CI 1.05–1.43; ALSPAC: OR 1.33, 95{\%} CI 1.19–1.48) and anxiety (Generation R: OR 1.24, 95{\%} CI 1.06–1.46; ALSPAC: OR 1.32, 95{\%} CI 1.19–1.47) were associated with a higher risk of child attention problems. In ALSPAC, paternal depression was also associated with a higher risk of child attention problems (OR 1.11, 95{\%} CI 1.00–1.24). After adjusting for maternal symptoms after giving birth, antenatal maternal depression and anxiety were no longer associated with child attention problems in Generation R. Moreover, there was little statistical evidence that antenatal maternal and paternal depression and anxiety had a substantially different effect on attention problems of the child.Conclusions:  The apparent intrauterine effect of maternal depression and anxiety on offspring-behavioural problems may be partly explained by residual confounding. There was little evidence of a difference between the strength of associations of maternal and paternal symptoms during pregnancy with offspring-attention problems. That maternal symptoms after childbirth were also associated with offspring-behavioural problems may indicate a contribution of genetic influences to the association.",
author = "{van Batenburg-Eddes}, T. and M.J. Brion and J. Henrichs and V.W. Jaddoe and A. Hofman and F.C. Verhulst and D.A. Lawlor and {Davey Smith}, G. and H.W. Tiemeier",
year = "2013",
doi = "10.1111/jcpp.12023",
language = "English",
volume = "54",
pages = "591--600",
journal = "Journal of Child Psychology and Psychiatry",
issn = "0021-9630",
publisher = "Wiley",
number = "5",

}

van Batenburg-Eddes, T, Brion, MJ, Henrichs, J, Jaddoe, VW, Hofman, A, Verhulst, FC, Lawlor, DA, Davey Smith, G & Tiemeier, HW 2013, 'Parental depressive and anxiety symptoms during pregnancy and attention problems in children: A cross-cohort consistency study', Journal of Child Psychology and Psychiatry, vol. 54, no. 5, pp. 591-600. https://doi.org/10.1111/jcpp.12023

Parental depressive and anxiety symptoms during pregnancy and attention problems in children : A cross-cohort consistency study. / van Batenburg-Eddes, T.; Brion, M.J.; Henrichs, J.; Jaddoe, V.W.; Hofman, A.; Verhulst, F.C.; Lawlor, D.A.; Davey Smith, G.; Tiemeier, H.W.

In: Journal of Child Psychology and Psychiatry, Vol. 54, No. 5, 2013, p. 591-600.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Parental depressive and anxiety symptoms during pregnancy and attention problems in children

T2 - A cross-cohort consistency study

AU - van Batenburg-Eddes, T.

AU - Brion, M.J.

AU - Henrichs, J.

AU - Jaddoe, V.W.

AU - Hofman, A.

AU - Verhulst, F.C.

AU - Lawlor, D.A.

AU - Davey Smith, G.

AU - Tiemeier, H.W.

PY - 2013

Y1 - 2013

N2 - Background:  Maternal depression and anxiety during pregnancy have been associated with offspring-attention deficit problems.Aim:  We explored possible intrauterine effects by comparing maternal and paternal symptoms during pregnancy, by investigating cross-cohort consistency, and by investigating whether parental symptoms in early childhood may explain any observed intrauterine effect.Methods:  This study was conducted in two cohorts (Generation R, n = 2,280 and ALSPAC, n = 3,442). Pregnant women and their partners completed questionnaires to assess symptoms of depression and anxiety. Child attention problems were measured in Generation R at age 3 with the Child Behavior Checklist, and in ALSPAC at age 4 with the Strengths and Difficulties Questionnaire.Results:  In both cohorts, antenatal maternal symptoms of depression (Generation R: OR 1.23, 95% CI 1.05–1.43; ALSPAC: OR 1.33, 95% CI 1.19–1.48) and anxiety (Generation R: OR 1.24, 95% CI 1.06–1.46; ALSPAC: OR 1.32, 95% CI 1.19–1.47) were associated with a higher risk of child attention problems. In ALSPAC, paternal depression was also associated with a higher risk of child attention problems (OR 1.11, 95% CI 1.00–1.24). After adjusting for maternal symptoms after giving birth, antenatal maternal depression and anxiety were no longer associated with child attention problems in Generation R. Moreover, there was little statistical evidence that antenatal maternal and paternal depression and anxiety had a substantially different effect on attention problems of the child.Conclusions:  The apparent intrauterine effect of maternal depression and anxiety on offspring-behavioural problems may be partly explained by residual confounding. There was little evidence of a difference between the strength of associations of maternal and paternal symptoms during pregnancy with offspring-attention problems. That maternal symptoms after childbirth were also associated with offspring-behavioural problems may indicate a contribution of genetic influences to the association.

AB - Background:  Maternal depression and anxiety during pregnancy have been associated with offspring-attention deficit problems.Aim:  We explored possible intrauterine effects by comparing maternal and paternal symptoms during pregnancy, by investigating cross-cohort consistency, and by investigating whether parental symptoms in early childhood may explain any observed intrauterine effect.Methods:  This study was conducted in two cohorts (Generation R, n = 2,280 and ALSPAC, n = 3,442). Pregnant women and their partners completed questionnaires to assess symptoms of depression and anxiety. Child attention problems were measured in Generation R at age 3 with the Child Behavior Checklist, and in ALSPAC at age 4 with the Strengths and Difficulties Questionnaire.Results:  In both cohorts, antenatal maternal symptoms of depression (Generation R: OR 1.23, 95% CI 1.05–1.43; ALSPAC: OR 1.33, 95% CI 1.19–1.48) and anxiety (Generation R: OR 1.24, 95% CI 1.06–1.46; ALSPAC: OR 1.32, 95% CI 1.19–1.47) were associated with a higher risk of child attention problems. In ALSPAC, paternal depression was also associated with a higher risk of child attention problems (OR 1.11, 95% CI 1.00–1.24). After adjusting for maternal symptoms after giving birth, antenatal maternal depression and anxiety were no longer associated with child attention problems in Generation R. Moreover, there was little statistical evidence that antenatal maternal and paternal depression and anxiety had a substantially different effect on attention problems of the child.Conclusions:  The apparent intrauterine effect of maternal depression and anxiety on offspring-behavioural problems may be partly explained by residual confounding. There was little evidence of a difference between the strength of associations of maternal and paternal symptoms during pregnancy with offspring-attention problems. That maternal symptoms after childbirth were also associated with offspring-behavioural problems may indicate a contribution of genetic influences to the association.

U2 - 10.1111/jcpp.12023

DO - 10.1111/jcpp.12023

M3 - Article

VL - 54

SP - 591

EP - 600

JO - Journal of Child Psychology and Psychiatry

JF - Journal of Child Psychology and Psychiatry

SN - 0021-9630

IS - 5

ER -