Patient-reported outcomes for patients undergoing radical cystectomy: A prospective case-control study

C.A. Goossens-Laan, P.J.M. Kil, J.L. Bosch, J. de Vries

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Purpose
The purpose of this study was to measure patient-reported outcomes (PROs) for patients with muscle-invasive bladder cancer (BC) before the diagnosis of BC was known, thus before cystectomy, and until 1 year postcystectomy. The differences in outcomes between a health status (HS) and quality of life (QoL) questionnaires were examined.
Methods
From July 2007 to July 2010, 598 patients with primary hematuria were enrolled in this prospective, multi-centre case–control (CC) study. Patients undergoing radical cystectomy (RC; N = 18) were compared with patients with other causes of hematuria (CC, N = 20). Measurement points were before diagnosis as well as 3, 6 and 12 months postcystectomy. Questionnaires used were the WHOQOL-BREF, SF-12, International Index of Erectile Function, and 10-item STAI-Trait scale.
Results
Prediagnosis patients who later appeared to have BC had the same QoL compared to CC patients. The prediagnosis physical component scale of HS and sexual function were significantly lower for RC vs. CC patients. RC patients had a better prediagnostic QoL and HS than postcystectomy at all time points.
Conclusions
This is the first case–control study with a baseline measurement of PROs before the diagnosis of BC was known. It shows lower physical health and sexual function for RC vs. CC before diagnosis is known. Until 1 year postcystectomy, QoL does not return to baseline level. Future studies including comorbidity and smoking history are needed to examine the generalizability of our results.
Keywords: Muscle-invasive bladder cancer, WHOQOL-BREF, Quality of life, Cystectomy
Original languageEnglish
Pages (from-to)189-200
JournalSupportive Care in Cancer
Volume22
DOIs
Publication statusPublished - 2014

Fingerprint

Cystectomy
Hematuria
Muscles
Reproductive Health
Comorbidity
History

Cite this

@article{708c1077612e48fba9a6bd0a090cacec,
title = "Patient-reported outcomes for patients undergoing radical cystectomy: A prospective case-control study",
abstract = "PurposeThe purpose of this study was to measure patient-reported outcomes (PROs) for patients with muscle-invasive bladder cancer (BC) before the diagnosis of BC was known, thus before cystectomy, and until 1 year postcystectomy. The differences in outcomes between a health status (HS) and quality of life (QoL) questionnaires were examined.MethodsFrom July 2007 to July 2010, 598 patients with primary hematuria were enrolled in this prospective, multi-centre case–control (CC) study. Patients undergoing radical cystectomy (RC; N = 18) were compared with patients with other causes of hematuria (CC, N = 20). Measurement points were before diagnosis as well as 3, 6 and 12 months postcystectomy. Questionnaires used were the WHOQOL-BREF, SF-12, International Index of Erectile Function, and 10-item STAI-Trait scale.ResultsPrediagnosis patients who later appeared to have BC had the same QoL compared to CC patients. The prediagnosis physical component scale of HS and sexual function were significantly lower for RC vs. CC patients. RC patients had a better prediagnostic QoL and HS than postcystectomy at all time points.ConclusionsThis is the first case–control study with a baseline measurement of PROs before the diagnosis of BC was known. It shows lower physical health and sexual function for RC vs. CC before diagnosis is known. Until 1 year postcystectomy, QoL does not return to baseline level. Future studies including comorbidity and smoking history are needed to examine the generalizability of our results.Keywords: Muscle-invasive bladder cancer, WHOQOL-BREF, Quality of life, Cystectomy",
author = "C.A. Goossens-Laan and P.J.M. Kil and J.L. Bosch and {de Vries}, J.",
year = "2014",
doi = "10.1007/s00520-013-1946-9",
language = "English",
volume = "22",
pages = "189--200",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer",

}

Patient-reported outcomes for patients undergoing radical cystectomy : A prospective case-control study. / Goossens-Laan, C.A.; Kil, P.J.M.; Bosch, J.L.; de Vries, J.

In: Supportive Care in Cancer, Vol. 22, 2014, p. 189-200.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Patient-reported outcomes for patients undergoing radical cystectomy

T2 - A prospective case-control study

AU - Goossens-Laan, C.A.

AU - Kil, P.J.M.

AU - Bosch, J.L.

AU - de Vries, J.

PY - 2014

Y1 - 2014

N2 - PurposeThe purpose of this study was to measure patient-reported outcomes (PROs) for patients with muscle-invasive bladder cancer (BC) before the diagnosis of BC was known, thus before cystectomy, and until 1 year postcystectomy. The differences in outcomes between a health status (HS) and quality of life (QoL) questionnaires were examined.MethodsFrom July 2007 to July 2010, 598 patients with primary hematuria were enrolled in this prospective, multi-centre case–control (CC) study. Patients undergoing radical cystectomy (RC; N = 18) were compared with patients with other causes of hematuria (CC, N = 20). Measurement points were before diagnosis as well as 3, 6 and 12 months postcystectomy. Questionnaires used were the WHOQOL-BREF, SF-12, International Index of Erectile Function, and 10-item STAI-Trait scale.ResultsPrediagnosis patients who later appeared to have BC had the same QoL compared to CC patients. The prediagnosis physical component scale of HS and sexual function were significantly lower for RC vs. CC patients. RC patients had a better prediagnostic QoL and HS than postcystectomy at all time points.ConclusionsThis is the first case–control study with a baseline measurement of PROs before the diagnosis of BC was known. It shows lower physical health and sexual function for RC vs. CC before diagnosis is known. Until 1 year postcystectomy, QoL does not return to baseline level. Future studies including comorbidity and smoking history are needed to examine the generalizability of our results.Keywords: Muscle-invasive bladder cancer, WHOQOL-BREF, Quality of life, Cystectomy

AB - PurposeThe purpose of this study was to measure patient-reported outcomes (PROs) for patients with muscle-invasive bladder cancer (BC) before the diagnosis of BC was known, thus before cystectomy, and until 1 year postcystectomy. The differences in outcomes between a health status (HS) and quality of life (QoL) questionnaires were examined.MethodsFrom July 2007 to July 2010, 598 patients with primary hematuria were enrolled in this prospective, multi-centre case–control (CC) study. Patients undergoing radical cystectomy (RC; N = 18) were compared with patients with other causes of hematuria (CC, N = 20). Measurement points were before diagnosis as well as 3, 6 and 12 months postcystectomy. Questionnaires used were the WHOQOL-BREF, SF-12, International Index of Erectile Function, and 10-item STAI-Trait scale.ResultsPrediagnosis patients who later appeared to have BC had the same QoL compared to CC patients. The prediagnosis physical component scale of HS and sexual function were significantly lower for RC vs. CC patients. RC patients had a better prediagnostic QoL and HS than postcystectomy at all time points.ConclusionsThis is the first case–control study with a baseline measurement of PROs before the diagnosis of BC was known. It shows lower physical health and sexual function for RC vs. CC before diagnosis is known. Until 1 year postcystectomy, QoL does not return to baseline level. Future studies including comorbidity and smoking history are needed to examine the generalizability of our results.Keywords: Muscle-invasive bladder cancer, WHOQOL-BREF, Quality of life, Cystectomy

U2 - 10.1007/s00520-013-1946-9

DO - 10.1007/s00520-013-1946-9

M3 - Article

VL - 22

SP - 189

EP - 200

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

ER -