Patients with diffuse axonal injury can recover to a favourable long term functional and quality of life outcome

M.M. van Eijck, J. van der Naalt, M. de Jongh, G.G. Schoonman, A.W. Oldenbeuving, J. Peluso, J. de Vries, G. Roks

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Functional outcome and quality of life are difficult to predict in patients with diffuse axonal injury (DAI) after traumatic brain injury (TBI). The primary aim of this cross-sectional cohort study was to assess the long-term functional outcome in patients with DAI and to identify prognostic factors. Secondly, health-related quality of life (HRQL) at long-term follow-up was assessed. Patients aged ≥16 with TBI and DAI (admitted 2008-2014) were included. Clinical and imaging data were collected. The primary outcome parameter was the Glasgow Coma Scale Extended (GOSE) at long-term follow-up. Secondly, the HRQL was assessed with the Quality Of Life after Brain Injury (Qolibri) questionnaire. DAI was diagnosed in 185 patients. Long-term functional outcome was obtained in 134 patients (72%), median follow-up 54 months (range 14-100). 51% had a favourable outcome (GOSE 6-8). Independent prognostic factors were age, pupillary reaction, Hb, DAI grading, and return of consciousness ≤7 days. Sixty-two percent had a good HRQL, after a median follow-up of 57 months (range 14-100) with age as an independent prognostic factor. More than half of patients with DAI had a favourable functional outcome and a good HRQL at long-term follow-up. Also in patients with a DAI grade 3 a favourable outcome was seen. HRQL is a clinically relevant outcome measure since it reflects perceived outcome by patients. Independent prognostic variables for the functional outcome were factors obtained in the acute phase after injury, whereas age was an independent prognostic factor for HRQL.
Original languageEnglish
Pages (from-to)2357–2364
JournalJournal of Neurotrauma
Volume35
Issue number20
DOIs
Publication statusPublished - 2018

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Diffuse Axonal Injury
Glasgow Coma Scale
Consciousness
Cross-Sectional Studies

Keywords

  • CLOSED-HEAD INJURY
  • CORPUS-CALLOSUM
  • DAI
  • GOSE
  • HRQL
  • IMPACT
  • LESIONS
  • LONGITUDINAL MRI
  • MODERATE
  • PREDICTION
  • PROGNOSIS
  • QOLIBRI
  • SCALE
  • TBI
  • TRAUMATIC BRAIN-INJURY

Cite this

van Eijck, M.M. ; van der Naalt, J. ; de Jongh, M. ; Schoonman, G.G. ; Oldenbeuving, A.W. ; Peluso, J. ; de Vries, J. ; Roks, G. / Patients with diffuse axonal injury can recover to a favourable long term functional and quality of life outcome. In: Journal of Neurotrauma. 2018 ; Vol. 35, No. 20. pp. 2357–2364.
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title = "Patients with diffuse axonal injury can recover to a favourable long term functional and quality of life outcome",
abstract = "Functional outcome and quality of life are difficult to predict in patients with diffuse axonal injury (DAI) after traumatic brain injury (TBI). The primary aim of this cross-sectional cohort study was to assess the long-term functional outcome in patients with DAI and to identify prognostic factors. Secondly, health-related quality of life (HRQL) at long-term follow-up was assessed. Patients aged ≥16 with TBI and DAI (admitted 2008-2014) were included. Clinical and imaging data were collected. The primary outcome parameter was the Glasgow Coma Scale Extended (GOSE) at long-term follow-up. Secondly, the HRQL was assessed with the Quality Of Life after Brain Injury (Qolibri) questionnaire. DAI was diagnosed in 185 patients. Long-term functional outcome was obtained in 134 patients (72{\%}), median follow-up 54 months (range 14-100). 51{\%} had a favourable outcome (GOSE 6-8). Independent prognostic factors were age, pupillary reaction, Hb, DAI grading, and return of consciousness ≤7 days. Sixty-two percent had a good HRQL, after a median follow-up of 57 months (range 14-100) with age as an independent prognostic factor. More than half of patients with DAI had a favourable functional outcome and a good HRQL at long-term follow-up. Also in patients with a DAI grade 3 a favourable outcome was seen. HRQL is a clinically relevant outcome measure since it reflects perceived outcome by patients. Independent prognostic variables for the functional outcome were factors obtained in the acute phase after injury, whereas age was an independent prognostic factor for HRQL.",
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Patients with diffuse axonal injury can recover to a favourable long term functional and quality of life outcome. / van Eijck, M.M.; van der Naalt, J.; de Jongh, M.; Schoonman, G.G.; Oldenbeuving, A.W.; Peluso, J.; de Vries, J.; Roks, G.

In: Journal of Neurotrauma, Vol. 35, No. 20, 2018, p. 2357–2364.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Patients with diffuse axonal injury can recover to a favourable long term functional and quality of life outcome

AU - van Eijck, M.M.

AU - van der Naalt, J.

AU - de Jongh, M.

AU - Schoonman, G.G.

AU - Oldenbeuving, A.W.

AU - Peluso, J.

AU - de Vries, J.

AU - Roks, G.

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AB - Functional outcome and quality of life are difficult to predict in patients with diffuse axonal injury (DAI) after traumatic brain injury (TBI). The primary aim of this cross-sectional cohort study was to assess the long-term functional outcome in patients with DAI and to identify prognostic factors. Secondly, health-related quality of life (HRQL) at long-term follow-up was assessed. Patients aged ≥16 with TBI and DAI (admitted 2008-2014) were included. Clinical and imaging data were collected. The primary outcome parameter was the Glasgow Coma Scale Extended (GOSE) at long-term follow-up. Secondly, the HRQL was assessed with the Quality Of Life after Brain Injury (Qolibri) questionnaire. DAI was diagnosed in 185 patients. Long-term functional outcome was obtained in 134 patients (72%), median follow-up 54 months (range 14-100). 51% had a favourable outcome (GOSE 6-8). Independent prognostic factors were age, pupillary reaction, Hb, DAI grading, and return of consciousness ≤7 days. Sixty-two percent had a good HRQL, after a median follow-up of 57 months (range 14-100) with age as an independent prognostic factor. More than half of patients with DAI had a favourable functional outcome and a good HRQL at long-term follow-up. Also in patients with a DAI grade 3 a favourable outcome was seen. HRQL is a clinically relevant outcome measure since it reflects perceived outcome by patients. Independent prognostic variables for the functional outcome were factors obtained in the acute phase after injury, whereas age was an independent prognostic factor for HRQL.

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KW - CORPUS-CALLOSUM

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KW - GOSE

KW - HRQL

KW - IMPACT

KW - LESIONS

KW - LONGITUDINAL MRI

KW - MODERATE

KW - PREDICTION

KW - PROGNOSIS

KW - QOLIBRI

KW - SCALE

KW - TBI

KW - TRAUMATIC BRAIN-INJURY

U2 - 10.1089/neu.2018.5650

DO - 10.1089/neu.2018.5650

M3 - Article

VL - 35

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EP - 2364

JO - Journal of Neurotrauma

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SN - 0897-7151

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