Persistent heightened cortisol awakening response and adolescent internalizing symptoms

A 3-year longitudinal community study

S.A. Nelemans, W.W. Hale III, S.T.J. Branje, P.A.C. van Lier, L.M.C. Jansen, E. Platje, T. Frijns, H.M. Koot, W.H.J. Meeus

Research output: Contribution to journalArticleScientificpeer-review

Abstract

An atypical Cortisol Awakening Response (CAR) has been related to adult anxiety and depression, but little is known about the association between long-term atypical CAR and adolescent anxiety and depression. This study aimed to longitudinally identify subgroups of adolescents with distinct levels of CAR (i.e., adolescents with and without persistent atypical CAR) and to examine their development of anxiety and depressive symptoms over 3 successive years. A community sample of 184 Dutch adolescents (Mage = 14.99 at T1, 57 % boys) completed annual salivary cortisol assessments at home at time of awakening, and 30 and 60 min post-awakening (i.e., CAR) for 3 successive years. Adolescents also reported annually on their anxiety and depressive disorder symptoms. Latent Class Growth Analysis suggested two subgroups of adolescents with respect to CAR: a “low” group with stable low levels of AUCg (Area Under the Curve with respect to the ground) over time and a “high” group with high and increasing levels of AUCg over time. Controlling for sex, the high and low CAR groups significantly differed in depressive symptoms only, but none of the anxiety disorder symptoms. More specifically, adolescents in the high CAR group showed significantly higher mean levels of depressive symptoms over time compared to adolescents in the low CAR group. These results suggest that persistent heightened CAR is a more consistent, yet modest, correlate of adolescent depressive symptoms than anxiety disorder symptoms.
Keywords: Cortisol Awakening Response (CAR), Area under the curve with respect to the ground (AUCg), Anxiety, Depression, Longitudinal, Adolescence
Original languageEnglish
Pages (from-to)767-777
JournalJournal of Abnormal Child Psychology
Volume42
Issue number5
DOIs
Publication statusPublished - 2014

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Nelemans, S. A., Hale III, W. W., Branje, S. T. J., van Lier, P. A. C., Jansen, L. M. C., Platje, E., ... Meeus, W. H. J. (2014). Persistent heightened cortisol awakening response and adolescent internalizing symptoms: A 3-year longitudinal community study. Journal of Abnormal Child Psychology, 42(5), 767-777 . https://doi.org/10.1007/s10802-013-9820-2
Nelemans, S.A. ; Hale III, W.W. ; Branje, S.T.J. ; van Lier, P.A.C. ; Jansen, L.M.C. ; Platje, E. ; Frijns, T. ; Koot, H.M. ; Meeus, W.H.J. / Persistent heightened cortisol awakening response and adolescent internalizing symptoms : A 3-year longitudinal community study. In: Journal of Abnormal Child Psychology. 2014 ; Vol. 42, No. 5. pp. 767-777 .
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title = "Persistent heightened cortisol awakening response and adolescent internalizing symptoms: A 3-year longitudinal community study",
abstract = "An atypical Cortisol Awakening Response (CAR) has been related to adult anxiety and depression, but little is known about the association between long-term atypical CAR and adolescent anxiety and depression. This study aimed to longitudinally identify subgroups of adolescents with distinct levels of CAR (i.e., adolescents with and without persistent atypical CAR) and to examine their development of anxiety and depressive symptoms over 3 successive years. A community sample of 184 Dutch adolescents (Mage = 14.99 at T1, 57 {\%} boys) completed annual salivary cortisol assessments at home at time of awakening, and 30 and 60 min post-awakening (i.e., CAR) for 3 successive years. Adolescents also reported annually on their anxiety and depressive disorder symptoms. Latent Class Growth Analysis suggested two subgroups of adolescents with respect to CAR: a “low” group with stable low levels of AUCg (Area Under the Curve with respect to the ground) over time and a “high” group with high and increasing levels of AUCg over time. Controlling for sex, the high and low CAR groups significantly differed in depressive symptoms only, but none of the anxiety disorder symptoms. More specifically, adolescents in the high CAR group showed significantly higher mean levels of depressive symptoms over time compared to adolescents in the low CAR group. These results suggest that persistent heightened CAR is a more consistent, yet modest, correlate of adolescent depressive symptoms than anxiety disorder symptoms.Keywords: Cortisol Awakening Response (CAR), Area under the curve with respect to the ground (AUCg), Anxiety, Depression, Longitudinal, Adolescence",
author = "S.A. Nelemans and {Hale III}, W.W. and S.T.J. Branje and {van Lier}, P.A.C. and L.M.C. Jansen and E. Platje and T. Frijns and H.M. Koot and W.H.J. Meeus",
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Nelemans, SA, Hale III, WW, Branje, STJ, van Lier, PAC, Jansen, LMC, Platje, E, Frijns, T, Koot, HM & Meeus, WHJ 2014, 'Persistent heightened cortisol awakening response and adolescent internalizing symptoms: A 3-year longitudinal community study', Journal of Abnormal Child Psychology, vol. 42, no. 5, pp. 767-777 . https://doi.org/10.1007/s10802-013-9820-2

Persistent heightened cortisol awakening response and adolescent internalizing symptoms : A 3-year longitudinal community study. / Nelemans, S.A.; Hale III, W.W.; Branje, S.T.J.; van Lier, P.A.C.; Jansen, L.M.C.; Platje, E.; Frijns, T.; Koot, H.M.; Meeus, W.H.J.

In: Journal of Abnormal Child Psychology, Vol. 42, No. 5, 2014, p. 767-777 .

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Persistent heightened cortisol awakening response and adolescent internalizing symptoms

T2 - A 3-year longitudinal community study

AU - Nelemans, S.A.

AU - Hale III, W.W.

AU - Branje, S.T.J.

AU - van Lier, P.A.C.

AU - Jansen, L.M.C.

AU - Platje, E.

AU - Frijns, T.

AU - Koot, H.M.

AU - Meeus, W.H.J.

PY - 2014

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N2 - An atypical Cortisol Awakening Response (CAR) has been related to adult anxiety and depression, but little is known about the association between long-term atypical CAR and adolescent anxiety and depression. This study aimed to longitudinally identify subgroups of adolescents with distinct levels of CAR (i.e., adolescents with and without persistent atypical CAR) and to examine their development of anxiety and depressive symptoms over 3 successive years. A community sample of 184 Dutch adolescents (Mage = 14.99 at T1, 57 % boys) completed annual salivary cortisol assessments at home at time of awakening, and 30 and 60 min post-awakening (i.e., CAR) for 3 successive years. Adolescents also reported annually on their anxiety and depressive disorder symptoms. Latent Class Growth Analysis suggested two subgroups of adolescents with respect to CAR: a “low” group with stable low levels of AUCg (Area Under the Curve with respect to the ground) over time and a “high” group with high and increasing levels of AUCg over time. Controlling for sex, the high and low CAR groups significantly differed in depressive symptoms only, but none of the anxiety disorder symptoms. More specifically, adolescents in the high CAR group showed significantly higher mean levels of depressive symptoms over time compared to adolescents in the low CAR group. These results suggest that persistent heightened CAR is a more consistent, yet modest, correlate of adolescent depressive symptoms than anxiety disorder symptoms.Keywords: Cortisol Awakening Response (CAR), Area under the curve with respect to the ground (AUCg), Anxiety, Depression, Longitudinal, Adolescence

AB - An atypical Cortisol Awakening Response (CAR) has been related to adult anxiety and depression, but little is known about the association between long-term atypical CAR and adolescent anxiety and depression. This study aimed to longitudinally identify subgroups of adolescents with distinct levels of CAR (i.e., adolescents with and without persistent atypical CAR) and to examine their development of anxiety and depressive symptoms over 3 successive years. A community sample of 184 Dutch adolescents (Mage = 14.99 at T1, 57 % boys) completed annual salivary cortisol assessments at home at time of awakening, and 30 and 60 min post-awakening (i.e., CAR) for 3 successive years. Adolescents also reported annually on their anxiety and depressive disorder symptoms. Latent Class Growth Analysis suggested two subgroups of adolescents with respect to CAR: a “low” group with stable low levels of AUCg (Area Under the Curve with respect to the ground) over time and a “high” group with high and increasing levels of AUCg over time. Controlling for sex, the high and low CAR groups significantly differed in depressive symptoms only, but none of the anxiety disorder symptoms. More specifically, adolescents in the high CAR group showed significantly higher mean levels of depressive symptoms over time compared to adolescents in the low CAR group. These results suggest that persistent heightened CAR is a more consistent, yet modest, correlate of adolescent depressive symptoms than anxiety disorder symptoms.Keywords: Cortisol Awakening Response (CAR), Area under the curve with respect to the ground (AUCg), Anxiety, Depression, Longitudinal, Adolescence

U2 - 10.1007/s10802-013-9820-2

DO - 10.1007/s10802-013-9820-2

M3 - Article

VL - 42

SP - 767

EP - 777

JO - Journal of Abnormal Child Psychology

JF - Journal of Abnormal Child Psychology

SN - 0091-0627

IS - 5

ER -