Physical activity and breast cancer risk

The European Prospective Investigation into Cancer and Nutrition

Petra H Lahmann, Christine Friedenreich, A.J. Schuit, Simonetta Salvini, Naomi E Allen, Tim J Key, Kay-Tee Khaw, Sheila Bingham, Petra H M Peeters, Evelyn Monninkhof, H Bas Bueno-de-Mesquita, Elisabet Wirfält, Jonas Manjer, Carlos A Gonzales, Eva Ardanaz, Pilar Amiano, José R Quirós, Carmen Navarro, Carmen Martinez, Franco Berrino & 19 others Domenico Palli, Rosario Tumino, Salvatore Panico, Paolo Vineis, Antonia Trichopoulou, Christina Bamia, Dimitrios Trichopoulos, Heiner Boeing, Mandy Schulz, Jakob Linseisen, Jenny Chang-Claude, Francoise Clavel Chapelon, Agnès Fournier, Marie-Christine Boutron-Ruault, Anne Tjønneland, Nina Føns Johnson, Kim Overvad, Rudolf Kaaks, Elio Riboli

Research output: Contribution to journalArticleScientificpeer-review

Abstract

There is convincing evidence for a decreased risk of breast cancer with increased physical activity. Uncertainties remain, however, about the role of different types of physical activity on breast cancer risk and the potential effect modification for these associations. We used data from 218,169 premenopausal and postmenopausal women from nine European countries, ages 20 to 80 years at study entry into the European Prospective Investigation into Cancer and Nutrition. Hazard ratios (HR) from multivariate Cox regression models were calculated using metabolic equivalent value-based physical activity variables categorized in quartiles, adjusted for age, study center, education, body mass index, smoking, alcohol use, age at menarche, age at first pregnancy, parity, current oral contraceptive use, and hormone replacement therapy use. The physical activity assessment included recreational, household, and occupational activities. A total physical activity index was estimated based on cross-tabulation of these separate types of activity. During 6.4 years of follow-up, 3,423 incident invasive breast cancers were identified. Overall, increasing total physical activity was associated with a reduction in breast cancer risk among postmenopausal women (P(trend) = 0.06). Specifically, household activity was associated with a significantly reduced risk in postmenopausal (HR, 0.81; 95% confidence interval, 0.70-0.93, highest versus the lowest quartile; P(trend) = 0.001) and premenopausal (HR, 0.71; 95% confidence interval, 0.55-0.90, highest versus lowest quartile; P(trend) = 0.003) women. Occupational activity and recreational activity were not significantly related to breast cancer risk in both premenopausal and postmenopausal women. This study provides additional evidence for a protective effect of physical activity on breast cancer risk.

Original languageEnglish
Pages (from-to)36-42
JournalCancer Epidemiology, Biomarkers & Prevention
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

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Exercise
Neoplasms
Confidence Intervals
Menarche
Parity
Proportional Hazards Models
Body Mass Index
Alcohols
Education

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms
  • Europe
  • Female
  • Humans
  • Middle Aged
  • Motor Activity
  • Nutritional Status
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Journal Article
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

Cite this

Lahmann, Petra H ; Friedenreich, Christine ; Schuit, A.J. ; Salvini, Simonetta ; Allen, Naomi E ; Key, Tim J ; Khaw, Kay-Tee ; Bingham, Sheila ; Peeters, Petra H M ; Monninkhof, Evelyn ; Bueno-de-Mesquita, H Bas ; Wirfält, Elisabet ; Manjer, Jonas ; Gonzales, Carlos A ; Ardanaz, Eva ; Amiano, Pilar ; Quirós, José R ; Navarro, Carmen ; Martinez, Carmen ; Berrino, Franco ; Palli, Domenico ; Tumino, Rosario ; Panico, Salvatore ; Vineis, Paolo ; Trichopoulou, Antonia ; Bamia, Christina ; Trichopoulos, Dimitrios ; Boeing, Heiner ; Schulz, Mandy ; Linseisen, Jakob ; Chang-Claude, Jenny ; Chapelon, Francoise Clavel ; Fournier, Agnès ; Boutron-Ruault, Marie-Christine ; Tjønneland, Anne ; Føns Johnson, Nina ; Overvad, Kim ; Kaaks, Rudolf ; Riboli, Elio. / Physical activity and breast cancer risk : The European Prospective Investigation into Cancer and Nutrition. In: Cancer Epidemiology, Biomarkers & Prevention . 2007 ; Vol. 16, No. 1. pp. 36-42.
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abstract = "There is convincing evidence for a decreased risk of breast cancer with increased physical activity. Uncertainties remain, however, about the role of different types of physical activity on breast cancer risk and the potential effect modification for these associations. We used data from 218,169 premenopausal and postmenopausal women from nine European countries, ages 20 to 80 years at study entry into the European Prospective Investigation into Cancer and Nutrition. Hazard ratios (HR) from multivariate Cox regression models were calculated using metabolic equivalent value-based physical activity variables categorized in quartiles, adjusted for age, study center, education, body mass index, smoking, alcohol use, age at menarche, age at first pregnancy, parity, current oral contraceptive use, and hormone replacement therapy use. The physical activity assessment included recreational, household, and occupational activities. A total physical activity index was estimated based on cross-tabulation of these separate types of activity. During 6.4 years of follow-up, 3,423 incident invasive breast cancers were identified. Overall, increasing total physical activity was associated with a reduction in breast cancer risk among postmenopausal women (P(trend) = 0.06). Specifically, household activity was associated with a significantly reduced risk in postmenopausal (HR, 0.81; 95{\%} confidence interval, 0.70-0.93, highest versus the lowest quartile; P(trend) = 0.001) and premenopausal (HR, 0.71; 95{\%} confidence interval, 0.55-0.90, highest versus lowest quartile; P(trend) = 0.003) women. Occupational activity and recreational activity were not significantly related to breast cancer risk in both premenopausal and postmenopausal women. This study provides additional evidence for a protective effect of physical activity on breast cancer risk.",
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Lahmann, PH, Friedenreich, C, Schuit, AJ, Salvini, S, Allen, NE, Key, TJ, Khaw, K-T, Bingham, S, Peeters, PHM, Monninkhof, E, Bueno-de-Mesquita, HB, Wirfält, E, Manjer, J, Gonzales, CA, Ardanaz, E, Amiano, P, Quirós, JR, Navarro, C, Martinez, C, Berrino, F, Palli, D, Tumino, R, Panico, S, Vineis, P, Trichopoulou, A, Bamia, C, Trichopoulos, D, Boeing, H, Schulz, M, Linseisen, J, Chang-Claude, J, Chapelon, FC, Fournier, A, Boutron-Ruault, M-C, Tjønneland, A, Føns Johnson, N, Overvad, K, Kaaks, R & Riboli, E 2007, 'Physical activity and breast cancer risk: The European Prospective Investigation into Cancer and Nutrition', Cancer Epidemiology, Biomarkers & Prevention , vol. 16, no. 1, pp. 36-42. https://doi.org/10.1158/1055-9965.EPI-06-0582

Physical activity and breast cancer risk : The European Prospective Investigation into Cancer and Nutrition. / Lahmann, Petra H; Friedenreich, Christine; Schuit, A.J.; Salvini, Simonetta; Allen, Naomi E; Key, Tim J; Khaw, Kay-Tee; Bingham, Sheila; Peeters, Petra H M; Monninkhof, Evelyn; Bueno-de-Mesquita, H Bas; Wirfält, Elisabet; Manjer, Jonas; Gonzales, Carlos A; Ardanaz, Eva; Amiano, Pilar; Quirós, José R; Navarro, Carmen; Martinez, Carmen; Berrino, Franco; Palli, Domenico; Tumino, Rosario; Panico, Salvatore; Vineis, Paolo; Trichopoulou, Antonia; Bamia, Christina; Trichopoulos, Dimitrios; Boeing, Heiner; Schulz, Mandy; Linseisen, Jakob; Chang-Claude, Jenny; Chapelon, Francoise Clavel; Fournier, Agnès; Boutron-Ruault, Marie-Christine; Tjønneland, Anne; Føns Johnson, Nina; Overvad, Kim; Kaaks, Rudolf; Riboli, Elio.

In: Cancer Epidemiology, Biomarkers & Prevention , Vol. 16, No. 1, 01.2007, p. 36-42.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Physical activity and breast cancer risk

T2 - The European Prospective Investigation into Cancer and Nutrition

AU - Lahmann, Petra H

AU - Friedenreich, Christine

AU - Schuit, A.J.

AU - Salvini, Simonetta

AU - Allen, Naomi E

AU - Key, Tim J

AU - Khaw, Kay-Tee

AU - Bingham, Sheila

AU - Peeters, Petra H M

AU - Monninkhof, Evelyn

AU - Bueno-de-Mesquita, H Bas

AU - Wirfält, Elisabet

AU - Manjer, Jonas

AU - Gonzales, Carlos A

AU - Ardanaz, Eva

AU - Amiano, Pilar

AU - Quirós, José R

AU - Navarro, Carmen

AU - Martinez, Carmen

AU - Berrino, Franco

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Vineis, Paolo

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Trichopoulos, Dimitrios

AU - Boeing, Heiner

AU - Schulz, Mandy

AU - Linseisen, Jakob

AU - Chang-Claude, Jenny

AU - Chapelon, Francoise Clavel

AU - Fournier, Agnès

AU - Boutron-Ruault, Marie-Christine

AU - Tjønneland, Anne

AU - Føns Johnson, Nina

AU - Overvad, Kim

AU - Kaaks, Rudolf

AU - Riboli, Elio

PY - 2007/1

Y1 - 2007/1

N2 - There is convincing evidence for a decreased risk of breast cancer with increased physical activity. Uncertainties remain, however, about the role of different types of physical activity on breast cancer risk and the potential effect modification for these associations. We used data from 218,169 premenopausal and postmenopausal women from nine European countries, ages 20 to 80 years at study entry into the European Prospective Investigation into Cancer and Nutrition. Hazard ratios (HR) from multivariate Cox regression models were calculated using metabolic equivalent value-based physical activity variables categorized in quartiles, adjusted for age, study center, education, body mass index, smoking, alcohol use, age at menarche, age at first pregnancy, parity, current oral contraceptive use, and hormone replacement therapy use. The physical activity assessment included recreational, household, and occupational activities. A total physical activity index was estimated based on cross-tabulation of these separate types of activity. During 6.4 years of follow-up, 3,423 incident invasive breast cancers were identified. Overall, increasing total physical activity was associated with a reduction in breast cancer risk among postmenopausal women (P(trend) = 0.06). Specifically, household activity was associated with a significantly reduced risk in postmenopausal (HR, 0.81; 95% confidence interval, 0.70-0.93, highest versus the lowest quartile; P(trend) = 0.001) and premenopausal (HR, 0.71; 95% confidence interval, 0.55-0.90, highest versus lowest quartile; P(trend) = 0.003) women. Occupational activity and recreational activity were not significantly related to breast cancer risk in both premenopausal and postmenopausal women. This study provides additional evidence for a protective effect of physical activity on breast cancer risk.

AB - There is convincing evidence for a decreased risk of breast cancer with increased physical activity. Uncertainties remain, however, about the role of different types of physical activity on breast cancer risk and the potential effect modification for these associations. We used data from 218,169 premenopausal and postmenopausal women from nine European countries, ages 20 to 80 years at study entry into the European Prospective Investigation into Cancer and Nutrition. Hazard ratios (HR) from multivariate Cox regression models were calculated using metabolic equivalent value-based physical activity variables categorized in quartiles, adjusted for age, study center, education, body mass index, smoking, alcohol use, age at menarche, age at first pregnancy, parity, current oral contraceptive use, and hormone replacement therapy use. The physical activity assessment included recreational, household, and occupational activities. A total physical activity index was estimated based on cross-tabulation of these separate types of activity. During 6.4 years of follow-up, 3,423 incident invasive breast cancers were identified. Overall, increasing total physical activity was associated with a reduction in breast cancer risk among postmenopausal women (P(trend) = 0.06). Specifically, household activity was associated with a significantly reduced risk in postmenopausal (HR, 0.81; 95% confidence interval, 0.70-0.93, highest versus the lowest quartile; P(trend) = 0.001) and premenopausal (HR, 0.71; 95% confidence interval, 0.55-0.90, highest versus lowest quartile; P(trend) = 0.003) women. Occupational activity and recreational activity were not significantly related to breast cancer risk in both premenopausal and postmenopausal women. This study provides additional evidence for a protective effect of physical activity on breast cancer risk.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Breast Neoplasms

KW - Europe

KW - Female

KW - Humans

KW - Middle Aged

KW - Motor Activity

KW - Nutritional Status

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Factors

KW - Journal Article

KW - Multicenter Study

KW - Research Support, Non-U.S. Gov't

U2 - 10.1158/1055-9965.EPI-06-0582

DO - 10.1158/1055-9965.EPI-06-0582

M3 - Article

VL - 16

SP - 36

EP - 42

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

SN - 1055-9965

IS - 1

ER -