Physical activity and health-related quality of life in multiple myeloma survivors: The PROFILES registry

Michela Servadio*, Francesco Cottone, Kathrin Sommer, Simone Oerlemans, Lonneke van de Poll-Franse, Fabio Efficace

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review


To investigate whether physical activity (PA) is associated with health-related quality of life (HRQOL) outcomes in multiple myeloma (MM) survivors up to 11 years after diagnosis.

We used data from the Patient Reported Outcomes Following Initial treatment and Long term Evaluation of Survivorship registry. We included 175 MM survivors diagnosed between 1999 and 2009 as registered by the Netherlands Cancer Registry. Sixty-four per cent (n=112/175) of patients who received the questionnaires, completed the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and the EORTC QLQ-MY20. Patients were classified into two groups: physically active and not physically active patients. Univariable and multivariable linear regression models were used to evaluate associations between PA and HRQOL outcomes.

Physically active patients reported a statistically significant higher global health status/HRQOL (p=0.001), lower fatigue (p=0.002) and fewer side effects of treatments (p=0.001), than not physically active patients. PA was not associated with psychological symptoms (ie, anxiety and depressive symptoms) (anxiety: p=0.139; depressive symptoms: p=0.073). Exploratory analyses performed on the other scales of the EORTC QLQ-C30 indicated statistically significant better outcomes in several functional and symptom subscales for physically active patients.

These findings might contribute to a better understanding of the relationship between PA and disease specific HRQOL aspects in MM survivors. Prospective studies are warranted to further elucidate on the beneficial effects of PA on HRQOL outcomes of MM survivors.
Original languageEnglish
Article numbere35
JournalBMJ Supportive & Palliative Care
Issue number4
Publication statusPublished - 2020


Dive into the research topics of 'Physical activity and health-related quality of life in multiple myeloma survivors: The PROFILES registry'. Together they form a unique fingerprint.

Cite this