Physical activity and stroke

A meta-analysis of observational data

G C W Wendel-Vos, A.J. Schuit, E J M Feskens, H C Boshuizen, W M M Verschuren, W H M Saris, D Kromhout

Research output: Contribution to journalReview articleScientificpeer-review

Abstract

Background:

Based on studies published so far, the protective effect of physical activity on stroke remains controversial. Specifically, there is a lack of insight into the sources of heterogeneity between studies.

Methods:

Meta-analysis of observational studies was used to quantify the relationship between physical activity and stroke and to explore sources of heterogeneity. In total, 31 relevant publications were included. Risk estimates and study characteristics were extracted from original studies and converted to a standard format for use in a central database.

Results:

Moderately intense physical activity compared with inactivity, showed a protective effect on total stroke for both occupational (RR = 0.64, 95% CI: 0.48-0.87) and leisure time physical activity (RR = 0.85, 95% CI: 0.78-0.93). High level occupational physical activity protected against ischaemic stroke compared with both moderate (RR = 0.77, 95% CI: 0.60-0.98) and inactive occupational levels (RR = 0.57, 95% CI: 0.43-0.77). High level compared with low level leisure time physical activity protected against total stroke (RR = 0.78, 95% CI: 0.71-0.85), haemorrhagic stroke (RR = 0.74, 95% CI: 0.57-0.96) as well as ischaemic stroke (RR = 0.79, 95% CI: 0.69-0.91). Studies conducted in Europe showed a stronger protective effect (RR = 0.47, 95% CI: 0.33-0.66) than studies conducted in the US (RR = 0.82, 95% CI: 0.75-0.90).

Conclusions:

Lack of physical activity is a modifiable risk factor for both total stroke and stroke subtypes. Moderately intense physical activity is sufficient to achieve risk reduction.

Original languageEnglish
Pages (from-to)787-798
JournalInternational Journal of Epidemiology
Volume33
Issue number4
DOIs
Publication statusPublished - Aug 2004
Externally publishedYes

Fingerprint

Leisure Activities
Risk Reduction Behavior
Databases

Keywords

  • Aged
  • Brain Ischemia
  • Exercise
  • Female
  • Humans
  • Intracranial Hemorrhages
  • Leisure Activities
  • Male
  • Middle Aged
  • Occupational Diseases
  • Stroke
  • Journal Article
  • Meta-Analysis
  • Review

Cite this

Wendel-Vos, G. C. W., Schuit, A. J., Feskens, E. J. M., Boshuizen, H. C., Verschuren, W. M. M., Saris, W. H. M., & Kromhout, D. (2004). Physical activity and stroke: A meta-analysis of observational data. International Journal of Epidemiology, 33(4), 787-798. https://doi.org/10.1093/ije/dyh168
Wendel-Vos, G C W ; Schuit, A.J. ; Feskens, E J M ; Boshuizen, H C ; Verschuren, W M M ; Saris, W H M ; Kromhout, D. / Physical activity and stroke : A meta-analysis of observational data. In: International Journal of Epidemiology. 2004 ; Vol. 33, No. 4. pp. 787-798.
@article{4561251f53dd48c998405cefb7d64cd1,
title = "Physical activity and stroke: A meta-analysis of observational data",
abstract = "Background: Based on studies published so far, the protective effect of physical activity on stroke remains controversial. Specifically, there is a lack of insight into the sources of heterogeneity between studies.Methods: Meta-analysis of observational studies was used to quantify the relationship between physical activity and stroke and to explore sources of heterogeneity. In total, 31 relevant publications were included. Risk estimates and study characteristics were extracted from original studies and converted to a standard format for use in a central database.Results: Moderately intense physical activity compared with inactivity, showed a protective effect on total stroke for both occupational (RR = 0.64, 95{\%} CI: 0.48-0.87) and leisure time physical activity (RR = 0.85, 95{\%} CI: 0.78-0.93). High level occupational physical activity protected against ischaemic stroke compared with both moderate (RR = 0.77, 95{\%} CI: 0.60-0.98) and inactive occupational levels (RR = 0.57, 95{\%} CI: 0.43-0.77). High level compared with low level leisure time physical activity protected against total stroke (RR = 0.78, 95{\%} CI: 0.71-0.85), haemorrhagic stroke (RR = 0.74, 95{\%} CI: 0.57-0.96) as well as ischaemic stroke (RR = 0.79, 95{\%} CI: 0.69-0.91). Studies conducted in Europe showed a stronger protective effect (RR = 0.47, 95{\%} CI: 0.33-0.66) than studies conducted in the US (RR = 0.82, 95{\%} CI: 0.75-0.90).Conclusions: Lack of physical activity is a modifiable risk factor for both total stroke and stroke subtypes. Moderately intense physical activity is sufficient to achieve risk reduction.",
keywords = "Aged, Brain Ischemia, Exercise, Female, Humans, Intracranial Hemorrhages, Leisure Activities, Male, Middle Aged, Occupational Diseases, Stroke, Journal Article, Meta-Analysis, Review",
author = "Wendel-Vos, {G C W} and A.J. Schuit and Feskens, {E J M} and Boshuizen, {H C} and Verschuren, {W M M} and Saris, {W H M} and D Kromhout",
year = "2004",
month = "8",
doi = "10.1093/ije/dyh168",
language = "English",
volume = "33",
pages = "787--798",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "OXFORD UNIV PRESS INC",
number = "4",

}

Wendel-Vos, GCW, Schuit, AJ, Feskens, EJM, Boshuizen, HC, Verschuren, WMM, Saris, WHM & Kromhout, D 2004, 'Physical activity and stroke: A meta-analysis of observational data', International Journal of Epidemiology, vol. 33, no. 4, pp. 787-798. https://doi.org/10.1093/ije/dyh168

Physical activity and stroke : A meta-analysis of observational data. / Wendel-Vos, G C W; Schuit, A.J.; Feskens, E J M; Boshuizen, H C; Verschuren, W M M; Saris, W H M; Kromhout, D.

In: International Journal of Epidemiology, Vol. 33, No. 4, 08.2004, p. 787-798.

Research output: Contribution to journalReview articleScientificpeer-review

TY - JOUR

T1 - Physical activity and stroke

T2 - A meta-analysis of observational data

AU - Wendel-Vos, G C W

AU - Schuit, A.J.

AU - Feskens, E J M

AU - Boshuizen, H C

AU - Verschuren, W M M

AU - Saris, W H M

AU - Kromhout, D

PY - 2004/8

Y1 - 2004/8

N2 - Background: Based on studies published so far, the protective effect of physical activity on stroke remains controversial. Specifically, there is a lack of insight into the sources of heterogeneity between studies.Methods: Meta-analysis of observational studies was used to quantify the relationship between physical activity and stroke and to explore sources of heterogeneity. In total, 31 relevant publications were included. Risk estimates and study characteristics were extracted from original studies and converted to a standard format for use in a central database.Results: Moderately intense physical activity compared with inactivity, showed a protective effect on total stroke for both occupational (RR = 0.64, 95% CI: 0.48-0.87) and leisure time physical activity (RR = 0.85, 95% CI: 0.78-0.93). High level occupational physical activity protected against ischaemic stroke compared with both moderate (RR = 0.77, 95% CI: 0.60-0.98) and inactive occupational levels (RR = 0.57, 95% CI: 0.43-0.77). High level compared with low level leisure time physical activity protected against total stroke (RR = 0.78, 95% CI: 0.71-0.85), haemorrhagic stroke (RR = 0.74, 95% CI: 0.57-0.96) as well as ischaemic stroke (RR = 0.79, 95% CI: 0.69-0.91). Studies conducted in Europe showed a stronger protective effect (RR = 0.47, 95% CI: 0.33-0.66) than studies conducted in the US (RR = 0.82, 95% CI: 0.75-0.90).Conclusions: Lack of physical activity is a modifiable risk factor for both total stroke and stroke subtypes. Moderately intense physical activity is sufficient to achieve risk reduction.

AB - Background: Based on studies published so far, the protective effect of physical activity on stroke remains controversial. Specifically, there is a lack of insight into the sources of heterogeneity between studies.Methods: Meta-analysis of observational studies was used to quantify the relationship between physical activity and stroke and to explore sources of heterogeneity. In total, 31 relevant publications were included. Risk estimates and study characteristics were extracted from original studies and converted to a standard format for use in a central database.Results: Moderately intense physical activity compared with inactivity, showed a protective effect on total stroke for both occupational (RR = 0.64, 95% CI: 0.48-0.87) and leisure time physical activity (RR = 0.85, 95% CI: 0.78-0.93). High level occupational physical activity protected against ischaemic stroke compared with both moderate (RR = 0.77, 95% CI: 0.60-0.98) and inactive occupational levels (RR = 0.57, 95% CI: 0.43-0.77). High level compared with low level leisure time physical activity protected against total stroke (RR = 0.78, 95% CI: 0.71-0.85), haemorrhagic stroke (RR = 0.74, 95% CI: 0.57-0.96) as well as ischaemic stroke (RR = 0.79, 95% CI: 0.69-0.91). Studies conducted in Europe showed a stronger protective effect (RR = 0.47, 95% CI: 0.33-0.66) than studies conducted in the US (RR = 0.82, 95% CI: 0.75-0.90).Conclusions: Lack of physical activity is a modifiable risk factor for both total stroke and stroke subtypes. Moderately intense physical activity is sufficient to achieve risk reduction.

KW - Aged

KW - Brain Ischemia

KW - Exercise

KW - Female

KW - Humans

KW - Intracranial Hemorrhages

KW - Leisure Activities

KW - Male

KW - Middle Aged

KW - Occupational Diseases

KW - Stroke

KW - Journal Article

KW - Meta-Analysis

KW - Review

U2 - 10.1093/ije/dyh168

DO - 10.1093/ije/dyh168

M3 - Review article

VL - 33

SP - 787

EP - 798

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 4

ER -

Wendel-Vos GCW, Schuit AJ, Feskens EJM, Boshuizen HC, Verschuren WMM, Saris WHM et al. Physical activity and stroke: A meta-analysis of observational data. International Journal of Epidemiology. 2004 Aug;33(4):787-798. https://doi.org/10.1093/ije/dyh168