TY - JOUR
T1 - Plasma and dietary linoleic acid and 3-year risk of type 2 diabetes after myocardial infarction
T2 - A prospective analysis in the alpha omega cohort
AU - Pertiwi, Kamalita
AU - Wanders, Anne J.
AU - Harbers, Marjolein C.
AU - Kuepers, Leanne K.
AU - Soedamah-Muthu, Sabita S.
AU - de Goede, Janette
AU - Zock, Peter L.
AU - Geleijnse, Johanna M.
PY - 2020
Y1 - 2020
N2 - Oblective To study plasma and dietary linoleic acid (LA) in relation to type 2 diabetes risk in post-myocardial infarction (MI) patients. Research design and methodsWe included 3,257 patients aged 60-80 years (80% male) with a median time since MI of 3.5 years from the Alpha Omega Cohort and who were initially free of type 2 diabetes. At baseline (2002-2006), plasma LA was measured in cholesteryl esters, and dietary LA was estimated with a 203-item food-frequency questionnaire. Incident type 2 diabetes was ascertained through self-reported physician diagnosis and medication use. Hazard ratios (with 95% CIs) were calculated by Cox regressions, in which dietary LA isocalorically replaced the sum of saturated (SFA) and trans fatty acids (TFA). ResultsMean +/- SD circulating and dietary LA was 50.1 +/- 4.9% and 5.9 +/- 2.1% energy, respectively. Plasma and dietary LA were weakly correlated (Spearman r = 0.13, P <0.001). During a median follow-up of 41 months, 171 patients developed type 2 diabetes. Plasma LA was inversely associated with type 2 diabetes risk (quintile [Q]5 vs. Q1: 0.44 [0.26, 0.75]; per 5%: 0.73 [0.62, 0.86]). Substitution of dietary LA for SFA+TFA showed no association with type 2 diabetes risk (Q5 vs. Q1: 0.78 [0.36, 1.72]; per 5% energy: 1.18 [0.59, 2.35]). Adjustment for markers of de novo lipogenesis attenuated plasma LA associations. Conclusions In our cohort of post-MI patients, plasma LA was inversely related to type 2 diabetes risk, whereas dietary LA was not related. Further research is needed to assess whether plasma LA indicates metabolic state rather than dietary LA in these patients.
AB - Oblective To study plasma and dietary linoleic acid (LA) in relation to type 2 diabetes risk in post-myocardial infarction (MI) patients. Research design and methodsWe included 3,257 patients aged 60-80 years (80% male) with a median time since MI of 3.5 years from the Alpha Omega Cohort and who were initially free of type 2 diabetes. At baseline (2002-2006), plasma LA was measured in cholesteryl esters, and dietary LA was estimated with a 203-item food-frequency questionnaire. Incident type 2 diabetes was ascertained through self-reported physician diagnosis and medication use. Hazard ratios (with 95% CIs) were calculated by Cox regressions, in which dietary LA isocalorically replaced the sum of saturated (SFA) and trans fatty acids (TFA). ResultsMean +/- SD circulating and dietary LA was 50.1 +/- 4.9% and 5.9 +/- 2.1% energy, respectively. Plasma and dietary LA were weakly correlated (Spearman r = 0.13, P <0.001). During a median follow-up of 41 months, 171 patients developed type 2 diabetes. Plasma LA was inversely associated with type 2 diabetes risk (quintile [Q]5 vs. Q1: 0.44 [0.26, 0.75]; per 5%: 0.73 [0.62, 0.86]). Substitution of dietary LA for SFA+TFA showed no association with type 2 diabetes risk (Q5 vs. Q1: 0.78 [0.36, 1.72]; per 5% energy: 1.18 [0.59, 2.35]). Adjustment for markers of de novo lipogenesis attenuated plasma LA associations. Conclusions In our cohort of post-MI patients, plasma LA was inversely related to type 2 diabetes risk, whereas dietary LA was not related. Further research is needed to assess whether plasma LA indicates metabolic state rather than dietary LA in these patients.
KW - FOOD-FREQUENCY QUESTIONNAIRE
KW - FATTY-ACIDS
KW - CARDIOVASCULAR RISK
KW - OMEGA-3-FATTY-ACIDS
KW - PREDICTORS
KW - BIOMARKER
KW - VALIDITY
KW - CANCER
KW - BLOOD
UR - http://www.scopus.com/inward/record.url?scp=85078368270&partnerID=8YFLogxK
U2 - 10.2337/dc19-1483
DO - 10.2337/dc19-1483
M3 - Article
VL - 43
SP - 358
EP - 365
JO - Diabetes Care: The Journal of Clinical and Applied Research and Education
JF - Diabetes Care: The Journal of Clinical and Applied Research and Education
SN - 0149-5992
IS - 2
ER -