Population coding and neural rhythmicity in the orbitofrontal cortex

Cyriel M A Pennartz, Marijn van Wingerden, Martin Vinck

Research output: Contribution to journalReview articleScientificpeer-review

Abstract

The orbitofrontal cortex has been implicated in the prediction of valuable outcomes based on environmental stimuli. However, it remains unknown how it represents outcome-predictive information at the population level, and how it provides temporal structure to such representations. Here, we pay attention especially to the population coding of probabilistic reward, and to the importance of orbitofrontal theta- and gamma-band rhythmicity in relation to target areas. When rats learned to associate odors to food outcome with variable likelihood, we found single-cell and population coding of reward probability, but not uncertainty. In related experiments, reward anticipation correlated to firing activity locking to theta-band oscillations. In contrast, gamma-band activity was associated with a firing-rate suppression of neurons that was most active during goal-directed movement. Orbitofrontal coding of outcome-relevant parameters appears bound to all relevant temporal phases of behavioral tasks, has a distributed nature, and is temporally structured according to multiple modes of rhythmicity.

Original languageEnglish
Pages (from-to)149-61
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume1239
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

Fingerprint

Odors
Periodicity
Neurons
Rats
Experiments
Uncertainty
Reward
Cortex

Keywords

  • Animals
  • Behavior
  • Behavior, Animal
  • Conditioning, Operant
  • Cortical Synchronization
  • Frontal Lobe/physiology
  • Humans
  • Models, Psychological
  • Neurons/physiology
  • Periodicity
  • Physiology, Comparative/methods
  • Reversal Learning
  • Reward

Cite this

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title = "Population coding and neural rhythmicity in the orbitofrontal cortex",
abstract = "The orbitofrontal cortex has been implicated in the prediction of valuable outcomes based on environmental stimuli. However, it remains unknown how it represents outcome-predictive information at the population level, and how it provides temporal structure to such representations. Here, we pay attention especially to the population coding of probabilistic reward, and to the importance of orbitofrontal theta- and gamma-band rhythmicity in relation to target areas. When rats learned to associate odors to food outcome with variable likelihood, we found single-cell and population coding of reward probability, but not uncertainty. In related experiments, reward anticipation correlated to firing activity locking to theta-band oscillations. In contrast, gamma-band activity was associated with a firing-rate suppression of neurons that was most active during goal-directed movement. Orbitofrontal coding of outcome-relevant parameters appears bound to all relevant temporal phases of behavioral tasks, has a distributed nature, and is temporally structured according to multiple modes of rhythmicity.",
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author = "Pennartz, {Cyriel M A} and {van Wingerden}, Marijn and Martin Vinck",
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Population coding and neural rhythmicity in the orbitofrontal cortex. / Pennartz, Cyriel M A; van Wingerden, Marijn; Vinck, Martin.

In: Annals of the New York Academy of Sciences, Vol. 1239, 12.2011, p. 149-61.

Research output: Contribution to journalReview articleScientificpeer-review

TY - JOUR

T1 - Population coding and neural rhythmicity in the orbitofrontal cortex

AU - Pennartz, Cyriel M A

AU - van Wingerden, Marijn

AU - Vinck, Martin

N1 - © 2011 New York Academy of Sciences.

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Y1 - 2011/12

N2 - The orbitofrontal cortex has been implicated in the prediction of valuable outcomes based on environmental stimuli. However, it remains unknown how it represents outcome-predictive information at the population level, and how it provides temporal structure to such representations. Here, we pay attention especially to the population coding of probabilistic reward, and to the importance of orbitofrontal theta- and gamma-band rhythmicity in relation to target areas. When rats learned to associate odors to food outcome with variable likelihood, we found single-cell and population coding of reward probability, but not uncertainty. In related experiments, reward anticipation correlated to firing activity locking to theta-band oscillations. In contrast, gamma-band activity was associated with a firing-rate suppression of neurons that was most active during goal-directed movement. Orbitofrontal coding of outcome-relevant parameters appears bound to all relevant temporal phases of behavioral tasks, has a distributed nature, and is temporally structured according to multiple modes of rhythmicity.

AB - The orbitofrontal cortex has been implicated in the prediction of valuable outcomes based on environmental stimuli. However, it remains unknown how it represents outcome-predictive information at the population level, and how it provides temporal structure to such representations. Here, we pay attention especially to the population coding of probabilistic reward, and to the importance of orbitofrontal theta- and gamma-band rhythmicity in relation to target areas. When rats learned to associate odors to food outcome with variable likelihood, we found single-cell and population coding of reward probability, but not uncertainty. In related experiments, reward anticipation correlated to firing activity locking to theta-band oscillations. In contrast, gamma-band activity was associated with a firing-rate suppression of neurons that was most active during goal-directed movement. Orbitofrontal coding of outcome-relevant parameters appears bound to all relevant temporal phases of behavioral tasks, has a distributed nature, and is temporally structured according to multiple modes of rhythmicity.

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KW - Models, Psychological

KW - Neurons/physiology

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KW - Physiology, Comparative/methods

KW - Reversal Learning

KW - Reward

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