PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease Investigating Trajectories): Overview of design and rationale of an international prospective peripheral arterial disease study

K.G.E. Smolderen, Kensey Gosch, Manesh R. Patel, W Schuyler Jones, Alan T Hirsch, John Beltrame, Rob Fitridge, Mehdi H Shishehbor, J. Denollet, Patrick Vriens, Jan Heyligers, Nancy Stone MEd, Herbert Aronow, J Dawn Abbott, Clementine Labrosciano, Rudolf Tutein-Nolthenius, John A Spertus

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Abstract

Background: 

Health status outcomes, including symptoms, functional status, and quality of life, are critically important outcomes from patients' perspectives. The PORTRAIT study (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories) was designed to prospectively define health status outcomes and examine associations between patients' characteristics and care to these outcomes among those presenting with new-onset or worsened claudication.

Methods and results: 

PORTRAIT screened 3637 patients with an abnormal ankle-brachial index and new, or worsened, claudication symptoms from 16 peripheral arterial disease (PAD) specialty clinics in the United States, the Netherlands, and Australia between June 2, 2011, and December 3, 2015. Of the 1608 eligible patients, 1275 (79%) were enrolled. Before treatment, patients were interviewed to obtain their demographics, PAD symptoms and health status, psychosocial characteristics, preferences for shared decision-making, socioeconomic, and cardiovascular risk factors. Patients' medical history, comorbidities, and PAD diagnostic information were abstracted from patients' medical records. Serial information about patients' health status, psychosocial, and lifestyle factors was collected at 3, 6, and 12 months by a core laboratory. Follow-up rates ranged from 84.2% to 91%. Clinical follow-up for PAD-related hospitalizations and major cardiovascular events is ongoing.

Conclusions: 

PORTRAIT systematically collected serial PAD-specific health status data as a foundation for risk stratification, comparative effectiveness studies, and clinicians' adherence to quality-based performance measures.


Original languageEnglish
Article numbere003860
Number of pages13
JournalCirculation. Cardiovascular Quality and Outcomes
Volume11
Issue number2
DOIs
Publication statusPublished - 2018

Keywords

  • HEALTH-STATUS
  • HEART-ASSOCIATION
  • INTERVENTIONAL-RADIOLOGY
  • LOWER-EXTREMITY
  • PRIMARY-CARE
  • QUALITY-OF-LIFE
  • QUESTIONNAIRE
  • TASK-FORCE
  • VASCULAR-MEDICINE
  • WRITING COMMITTEE
  • health status
  • peripheral arterial disease
  • quality of life
  • registries
  • risk factors

Fingerprint Dive into the research topics of 'PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease Investigating Trajectories): Overview of design and rationale of an international prospective peripheral arterial disease study'. Together they form a unique fingerprint.

  • Cite this

    Smolderen, K. G. E., Gosch, K., Patel, M. R., Jones, W. S., Hirsch, A. T., Beltrame, J., Fitridge, R., Shishehbor, M. H., Denollet, J., Vriens, P., Heyligers, J., Stone MEd, N., Aronow, H., Abbott, J. D., Labrosciano, C., Tutein-Nolthenius, R., & A Spertus, J. (2018). PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease Investigating Trajectories): Overview of design and rationale of an international prospective peripheral arterial disease study. Circulation. Cardiovascular Quality and Outcomes, 11(2), [e003860]. https://doi.org/10.1161/CIRCOUTCOMES.117.003860