PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease Investigating Trajectories)

Overview of design and rationale of an international prospective peripheral arterial disease study

K.G.E. Smolderen, Kensey Gosch, Manesh R. Patel, W Schuyler Jones, Alan T Hirsch, John Beltrame, Rob Fitridge, Mehdi H Shishehbor, J. Denollet, Patrick Vriens, Jan Heyligers, Nancy Stone MEd, Herbert Aronow, J Dawn Abbott, Clementine Labrosciano, Rudolf Tutein-Nolthenius, John A Spertus

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background: 

Health status outcomes, including symptoms, functional status, and quality of life, are critically important outcomes from patients' perspectives. The PORTRAIT study (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories) was designed to prospectively define health status outcomes and examine associations between patients' characteristics and care to these outcomes among those presenting with new-onset or worsened claudication.

Methods and results: 

PORTRAIT screened 3637 patients with an abnormal ankle-brachial index and new, or worsened, claudication symptoms from 16 peripheral arterial disease (PAD) specialty clinics in the United States, the Netherlands, and Australia between June 2, 2011, and December 3, 2015. Of the 1608 eligible patients, 1275 (79%) were enrolled. Before treatment, patients were interviewed to obtain their demographics, PAD symptoms and health status, psychosocial characteristics, preferences for shared decision-making, socioeconomic, and cardiovascular risk factors. Patients' medical history, comorbidities, and PAD diagnostic information were abstracted from patients' medical records. Serial information about patients' health status, psychosocial, and lifestyle factors was collected at 3, 6, and 12 months by a core laboratory. Follow-up rates ranged from 84.2% to 91%. Clinical follow-up for PAD-related hospitalizations and major cardiovascular events is ongoing.

Conclusions: 

PORTRAIT systematically collected serial PAD-specific health status data as a foundation for risk stratification, comparative effectiveness studies, and clinicians' adherence to quality-based performance measures.


Original languageEnglish
Article numbere003860
Number of pages13
JournalCirculation. Cardiovascular Quality and Outcomes
Volume11
Issue number2
DOIs
Publication statusPublished - 2018

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Ankle Brachial Index
Netherlands
Medical Records
Comorbidity

Keywords

  • HEALTH-STATUS
  • HEART-ASSOCIATION
  • INTERVENTIONAL-RADIOLOGY
  • LOWER-EXTREMITY
  • PRIMARY-CARE
  • QUALITY-OF-LIFE
  • QUESTIONNAIRE
  • TASK-FORCE
  • VASCULAR-MEDICINE
  • WRITING COMMITTEE
  • health status
  • peripheral arterial disease
  • quality of life
  • registries
  • risk factors

Cite this

Smolderen, K.G.E. ; Gosch, Kensey ; Patel, Manesh R. ; Jones, W Schuyler ; Hirsch, Alan T ; Beltrame, John ; Fitridge, Rob ; Shishehbor, Mehdi H ; Denollet, J. ; Vriens, Patrick ; Heyligers, Jan ; Stone MEd, Nancy ; Aronow, Herbert ; Abbott, J Dawn ; Labrosciano, Clementine ; Tutein-Nolthenius, Rudolf ; A Spertus, John. / PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease Investigating Trajectories) : Overview of design and rationale of an international prospective peripheral arterial disease study. In: Circulation. Cardiovascular Quality and Outcomes. 2018 ; Vol. 11, No. 2.
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title = "PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease Investigating Trajectories): Overview of design and rationale of an international prospective peripheral arterial disease study",
abstract = "Background: Health status outcomes, including symptoms, functional status, and quality of life, are critically important outcomes from patients' perspectives. The PORTRAIT study (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories) was designed to prospectively define health status outcomes and examine associations between patients' characteristics and care to these outcomes among those presenting with new-onset or worsened claudication.Methods and results: PORTRAIT screened 3637 patients with an abnormal ankle-brachial index and new, or worsened, claudication symptoms from 16 peripheral arterial disease (PAD) specialty clinics in the United States, the Netherlands, and Australia between June 2, 2011, and December 3, 2015. Of the 1608 eligible patients, 1275 (79{\%}) were enrolled. Before treatment, patients were interviewed to obtain their demographics, PAD symptoms and health status, psychosocial characteristics, preferences for shared decision-making, socioeconomic, and cardiovascular risk factors. Patients' medical history, comorbidities, and PAD diagnostic information were abstracted from patients' medical records. Serial information about patients' health status, psychosocial, and lifestyle factors was collected at 3, 6, and 12 months by a core laboratory. Follow-up rates ranged from 84.2{\%} to 91{\%}. Clinical follow-up for PAD-related hospitalizations and major cardiovascular events is ongoing.Conclusions: PORTRAIT systematically collected serial PAD-specific health status data as a foundation for risk stratification, comparative effectiveness studies, and clinicians' adherence to quality-based performance measures.",
keywords = "HEALTH-STATUS, HEART-ASSOCIATION, INTERVENTIONAL-RADIOLOGY, LOWER-EXTREMITY, PRIMARY-CARE, QUALITY-OF-LIFE, QUESTIONNAIRE, TASK-FORCE, VASCULAR-MEDICINE, WRITING COMMITTEE, health status, peripheral arterial disease, quality of life, registries, risk factors",
author = "K.G.E. Smolderen and Kensey Gosch and Patel, {Manesh R.} and Jones, {W Schuyler} and Hirsch, {Alan T} and John Beltrame and Rob Fitridge and Shishehbor, {Mehdi H} and J. Denollet and Patrick Vriens and Jan Heyligers and {Stone MEd}, Nancy and Herbert Aronow and Abbott, {J Dawn} and Clementine Labrosciano and Rudolf Tutein-Nolthenius and {A Spertus}, John",
note = "{\circledC} 2018 American Heart Association, Inc.",
year = "2018",
doi = "10.1161/CIRCOUTCOMES.117.003860",
language = "English",
volume = "11",
journal = "Circulation. Cardiovascular Quality and Outcomes",
issn = "1941-7705",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "2",

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Smolderen, KGE, Gosch, K, Patel, MR, Jones, WS, Hirsch, AT, Beltrame, J, Fitridge, R, Shishehbor, MH, Denollet, J, Vriens, P, Heyligers, J, Stone MEd, N, Aronow, H, Abbott, JD, Labrosciano, C, Tutein-Nolthenius, R & A Spertus, J 2018, 'PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease Investigating Trajectories): Overview of design and rationale of an international prospective peripheral arterial disease study', Circulation. Cardiovascular Quality and Outcomes, vol. 11, no. 2, e003860. https://doi.org/10.1161/CIRCOUTCOMES.117.003860

PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease Investigating Trajectories) : Overview of design and rationale of an international prospective peripheral arterial disease study. / Smolderen, K.G.E.; Gosch, Kensey; Patel, Manesh R.; Jones, W Schuyler; Hirsch, Alan T; Beltrame, John; Fitridge, Rob; Shishehbor, Mehdi H; Denollet, J.; Vriens, Patrick; Heyligers, Jan; Stone MEd, Nancy; Aronow, Herbert; Abbott, J Dawn; Labrosciano, Clementine; Tutein-Nolthenius, Rudolf; A Spertus, John.

In: Circulation. Cardiovascular Quality and Outcomes, Vol. 11, No. 2, e003860, 2018.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease Investigating Trajectories)

T2 - Overview of design and rationale of an international prospective peripheral arterial disease study

AU - Smolderen, K.G.E.

AU - Gosch, Kensey

AU - Patel, Manesh R.

AU - Jones, W Schuyler

AU - Hirsch, Alan T

AU - Beltrame, John

AU - Fitridge, Rob

AU - Shishehbor, Mehdi H

AU - Denollet, J.

AU - Vriens, Patrick

AU - Heyligers, Jan

AU - Stone MEd, Nancy

AU - Aronow, Herbert

AU - Abbott, J Dawn

AU - Labrosciano, Clementine

AU - Tutein-Nolthenius, Rudolf

AU - A Spertus, John

N1 - © 2018 American Heart Association, Inc.

PY - 2018

Y1 - 2018

N2 - Background: Health status outcomes, including symptoms, functional status, and quality of life, are critically important outcomes from patients' perspectives. The PORTRAIT study (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories) was designed to prospectively define health status outcomes and examine associations between patients' characteristics and care to these outcomes among those presenting with new-onset or worsened claudication.Methods and results: PORTRAIT screened 3637 patients with an abnormal ankle-brachial index and new, or worsened, claudication symptoms from 16 peripheral arterial disease (PAD) specialty clinics in the United States, the Netherlands, and Australia between June 2, 2011, and December 3, 2015. Of the 1608 eligible patients, 1275 (79%) were enrolled. Before treatment, patients were interviewed to obtain their demographics, PAD symptoms and health status, psychosocial characteristics, preferences for shared decision-making, socioeconomic, and cardiovascular risk factors. Patients' medical history, comorbidities, and PAD diagnostic information were abstracted from patients' medical records. Serial information about patients' health status, psychosocial, and lifestyle factors was collected at 3, 6, and 12 months by a core laboratory. Follow-up rates ranged from 84.2% to 91%. Clinical follow-up for PAD-related hospitalizations and major cardiovascular events is ongoing.Conclusions: PORTRAIT systematically collected serial PAD-specific health status data as a foundation for risk stratification, comparative effectiveness studies, and clinicians' adherence to quality-based performance measures.

AB - Background: Health status outcomes, including symptoms, functional status, and quality of life, are critically important outcomes from patients' perspectives. The PORTRAIT study (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories) was designed to prospectively define health status outcomes and examine associations between patients' characteristics and care to these outcomes among those presenting with new-onset or worsened claudication.Methods and results: PORTRAIT screened 3637 patients with an abnormal ankle-brachial index and new, or worsened, claudication symptoms from 16 peripheral arterial disease (PAD) specialty clinics in the United States, the Netherlands, and Australia between June 2, 2011, and December 3, 2015. Of the 1608 eligible patients, 1275 (79%) were enrolled. Before treatment, patients were interviewed to obtain their demographics, PAD symptoms and health status, psychosocial characteristics, preferences for shared decision-making, socioeconomic, and cardiovascular risk factors. Patients' medical history, comorbidities, and PAD diagnostic information were abstracted from patients' medical records. Serial information about patients' health status, psychosocial, and lifestyle factors was collected at 3, 6, and 12 months by a core laboratory. Follow-up rates ranged from 84.2% to 91%. Clinical follow-up for PAD-related hospitalizations and major cardiovascular events is ongoing.Conclusions: PORTRAIT systematically collected serial PAD-specific health status data as a foundation for risk stratification, comparative effectiveness studies, and clinicians' adherence to quality-based performance measures.

KW - HEALTH-STATUS

KW - HEART-ASSOCIATION

KW - INTERVENTIONAL-RADIOLOGY

KW - LOWER-EXTREMITY

KW - PRIMARY-CARE

KW - QUALITY-OF-LIFE

KW - QUESTIONNAIRE

KW - TASK-FORCE

KW - VASCULAR-MEDICINE

KW - WRITING COMMITTEE

KW - health status

KW - peripheral arterial disease

KW - quality of life

KW - registries

KW - risk factors

U2 - 10.1161/CIRCOUTCOMES.117.003860

DO - 10.1161/CIRCOUTCOMES.117.003860

M3 - Article

VL - 11

JO - Circulation. Cardiovascular Quality and Outcomes

JF - Circulation. Cardiovascular Quality and Outcomes

SN - 1941-7705

IS - 2

M1 - e003860

ER -