Predictors of persistent Medically Unexplained physical Symptoms

Findings from a general population study

J. van Eck van der Sluijs, M. Ten Have, R. de Graaf, C.A.T. Rijnders, H.W. Van Marwijk, C.M. van der Feltz-Cornelis

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Abstract

Objective:
To explore the persistency of Medically Unexplained Symptoms (MUS) and its prognostic factors in the general adult population. Knowledge of prognostic factors of MUS may indicate possible avenues for intervention development.

Methods:
Data were derived from the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2), a nationally representative face-to-face cohort study among the Dutch general population aged 18–64 years. We selected subjects with MUS at baseline and who participated at follow-up (N = 324) and reassessed those subjects for having MUS at 3 year follow-up. Logistic regression analyses were used to determine risk factors for persistency of MUS.

Results:
36.4% of the subjects had persistent MUS at follow-up. In logistic regression analyses adjusted for sex and age, persistency of MUS was predicted by the number of comorbid chronicmedical disorder(s), lower education, female sex, not having a paid job, parental psychopathology as well as lower functioning. In the logistic regression analysis in which all significant variables adjusted for sex and age were entered simultaneously, three variables predicted persistent MUS: parental psychopathology, the number of comorbid chronic medical disorder(s) and physical functioning, with odds ratios of 2.01 (1.20–3.38), 1.19 (1.01–1.40), and 0.99 (0.97–1.00), respectively.

Conclusion:
In the adult general population, MUS were persistent in over one third of the subjects with MUS at baseline. Persistency was significantly predicted by parental psychopathology, number of comorbid chronic medical disorders, and physical functioning. These findings warrant further research into early intervention and treatment options for persons with an increased risk of persistent MUS.
Original languageEnglish
Article number613
Number of pages10
JournalFrontiers in Psychiatry
Volume9
DOIs
Publication statusPublished - 2018

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Logistic Models
Medically Unexplained Symptoms
Health Surveys
Netherlands
Mental Health
Odds Ratio

Keywords

  • CHILDHOOD ADVERSITIES
  • FUNCTIONAL-SOMATIC SYMPTOMS
  • INCIDENCE STUDY-2
  • INTERNATIONAL DIAGNOSTIC INTERVIEW
  • MENTAL-HEALTH SURVEY
  • PATERNAL DEPRESSION
  • PRIMARY-CARE
  • PSYCHOLOGICAL MEDICINE
  • QUALITY-OF-LIFE
  • SOMATOFORM DISORDERS
  • course
  • general population
  • medically unexplained symptoms
  • persistency
  • prognosis

Cite this

@article{a2f9a2f3a89147dab72700fda1dd21fb,
title = "Predictors of persistent Medically Unexplained physical Symptoms: Findings from a general population study",
abstract = "Objective:To explore the persistency of Medically Unexplained Symptoms (MUS) and its prognostic factors in the general adult population. Knowledge of prognostic factors of MUS may indicate possible avenues for intervention development.Methods: Data were derived from the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2), a nationally representative face-to-face cohort study among the Dutch general population aged 18–64 years. We selected subjects with MUS at baseline and who participated at follow-up (N = 324) and reassessed those subjects for having MUS at 3 year follow-up. Logistic regression analyses were used to determine risk factors for persistency of MUS.Results:36.4{\%} of the subjects had persistent MUS at follow-up. In logistic regression analyses adjusted for sex and age, persistency of MUS was predicted by the number of comorbid chronicmedical disorder(s), lower education, female sex, not having a paid job, parental psychopathology as well as lower functioning. In the logistic regression analysis in which all significant variables adjusted for sex and age were entered simultaneously, three variables predicted persistent MUS: parental psychopathology, the number of comorbid chronic medical disorder(s) and physical functioning, with odds ratios of 2.01 (1.20–3.38), 1.19 (1.01–1.40), and 0.99 (0.97–1.00), respectively.Conclusion:In the adult general population, MUS were persistent in over one third of the subjects with MUS at baseline. Persistency was significantly predicted by parental psychopathology, number of comorbid chronic medical disorders, and physical functioning. These findings warrant further research into early intervention and treatment options for persons with an increased risk of persistent MUS.",
keywords = "CHILDHOOD ADVERSITIES, FUNCTIONAL-SOMATIC SYMPTOMS, INCIDENCE STUDY-2, INTERNATIONAL DIAGNOSTIC INTERVIEW, MENTAL-HEALTH SURVEY, PATERNAL DEPRESSION, PRIMARY-CARE, PSYCHOLOGICAL MEDICINE, QUALITY-OF-LIFE, SOMATOFORM DISORDERS, course, general population, medically unexplained symptoms, persistency, prognosis",
author = "{van Eck van der Sluijs}, J. and {Ten Have}, M. and {de Graaf}, R. and C.A.T. Rijnders and {Van Marwijk}, H.W. and {van der Feltz-Cornelis}, C.M.",
year = "2018",
doi = "10.3389/fpsyt.2018.00613",
language = "English",
volume = "9",
journal = "Frontiers in Psychiatry",
issn = "1664-0640",
publisher = "Frontiers Media S.A.",

}

Predictors of persistent Medically Unexplained physical Symptoms : Findings from a general population study. / van Eck van der Sluijs, J.; Ten Have, M.; de Graaf, R.; Rijnders, C.A.T.; Van Marwijk, H.W.; van der Feltz-Cornelis, C.M.

In: Frontiers in Psychiatry, Vol. 9, 613, 2018.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Predictors of persistent Medically Unexplained physical Symptoms

T2 - Findings from a general population study

AU - van Eck van der Sluijs, J.

AU - Ten Have, M.

AU - de Graaf, R.

AU - Rijnders, C.A.T.

AU - Van Marwijk, H.W.

AU - van der Feltz-Cornelis, C.M.

PY - 2018

Y1 - 2018

N2 - Objective:To explore the persistency of Medically Unexplained Symptoms (MUS) and its prognostic factors in the general adult population. Knowledge of prognostic factors of MUS may indicate possible avenues for intervention development.Methods: Data were derived from the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2), a nationally representative face-to-face cohort study among the Dutch general population aged 18–64 years. We selected subjects with MUS at baseline and who participated at follow-up (N = 324) and reassessed those subjects for having MUS at 3 year follow-up. Logistic regression analyses were used to determine risk factors for persistency of MUS.Results:36.4% of the subjects had persistent MUS at follow-up. In logistic regression analyses adjusted for sex and age, persistency of MUS was predicted by the number of comorbid chronicmedical disorder(s), lower education, female sex, not having a paid job, parental psychopathology as well as lower functioning. In the logistic regression analysis in which all significant variables adjusted for sex and age were entered simultaneously, three variables predicted persistent MUS: parental psychopathology, the number of comorbid chronic medical disorder(s) and physical functioning, with odds ratios of 2.01 (1.20–3.38), 1.19 (1.01–1.40), and 0.99 (0.97–1.00), respectively.Conclusion:In the adult general population, MUS were persistent in over one third of the subjects with MUS at baseline. Persistency was significantly predicted by parental psychopathology, number of comorbid chronic medical disorders, and physical functioning. These findings warrant further research into early intervention and treatment options for persons with an increased risk of persistent MUS.

AB - Objective:To explore the persistency of Medically Unexplained Symptoms (MUS) and its prognostic factors in the general adult population. Knowledge of prognostic factors of MUS may indicate possible avenues for intervention development.Methods: Data were derived from the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2), a nationally representative face-to-face cohort study among the Dutch general population aged 18–64 years. We selected subjects with MUS at baseline and who participated at follow-up (N = 324) and reassessed those subjects for having MUS at 3 year follow-up. Logistic regression analyses were used to determine risk factors for persistency of MUS.Results:36.4% of the subjects had persistent MUS at follow-up. In logistic regression analyses adjusted for sex and age, persistency of MUS was predicted by the number of comorbid chronicmedical disorder(s), lower education, female sex, not having a paid job, parental psychopathology as well as lower functioning. In the logistic regression analysis in which all significant variables adjusted for sex and age were entered simultaneously, three variables predicted persistent MUS: parental psychopathology, the number of comorbid chronic medical disorder(s) and physical functioning, with odds ratios of 2.01 (1.20–3.38), 1.19 (1.01–1.40), and 0.99 (0.97–1.00), respectively.Conclusion:In the adult general population, MUS were persistent in over one third of the subjects with MUS at baseline. Persistency was significantly predicted by parental psychopathology, number of comorbid chronic medical disorders, and physical functioning. These findings warrant further research into early intervention and treatment options for persons with an increased risk of persistent MUS.

KW - CHILDHOOD ADVERSITIES

KW - FUNCTIONAL-SOMATIC SYMPTOMS

KW - INCIDENCE STUDY-2

KW - INTERNATIONAL DIAGNOSTIC INTERVIEW

KW - MENTAL-HEALTH SURVEY

KW - PATERNAL DEPRESSION

KW - PRIMARY-CARE

KW - PSYCHOLOGICAL MEDICINE

KW - QUALITY-OF-LIFE

KW - SOMATOFORM DISORDERS

KW - course

KW - general population

KW - medically unexplained symptoms

KW - persistency

KW - prognosis

U2 - 10.3389/fpsyt.2018.00613

DO - 10.3389/fpsyt.2018.00613

M3 - Article

VL - 9

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

SN - 1664-0640

M1 - 613

ER -